WormBase Tree Display for Gene: WBGene00002993

WBGene00002993 SMap: S_parent: Sequence: F59G1
  Identity: Version: 1
    Name: CGC_name: lin-4 Person_evidence: WBPerson261
      Sequence_name: F59G1.6
      Molecular_name: F59G1.6
        F59G1.6a
        F59G1.6b
      Other_name: CELE_F59G1.6 Accession_evidence: NDB BX284602
      Public_name: lin-4
    DB_info: Database: SignaLink mirna cel-lin-4
        NDB locus_tag CELE_F59G1.6
        NCBI gene 266860
        RefSeq protein NR_000799.2
        RNAcentral URSid URS00001E2999
            URS0000278C03
            URS0000779DBB
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001265
    Gene_class: lin
    Reference_allele: WBVar00143592
    Allele (12)
    Legacy_information: e912pdi : heterochronic retarded adult hermaphrodites long abnormal movement vulvaless lack adult cuticle ES3 (adult) ES1 (larvae); HME0 (20x)/HME1 (15x) adult males lack copulatory structures ME0. NA1 (rare mutation).
      See also e912, n408, n409, n410
      [C.elegansII] e912pdi : heterochronic, retarded adult hermaphrodites long abnormal movement vulvaless lack adult cuticle ES3 (adult) ES1 (larvae); HME0 (20C)/HME1 (15C) adult males lack copulatory structures ME0. OA1: ma161 (resembles e912). Cloned: encodes two small RNAs with nocoding potential. [Lee et al. 1993; Wightman et al. 1993; GR; VT]
    Strain: WBStrain00026764
      WBStrain00026863
      WBStrain00027055
      WBStrain00027229
      WBStrain00027586
      WBStrain00040213
      WBStrain00004403
      WBStrain00006311
      WBStrain00051497
      WBStrain00051632
    RNASeq_FPKM (74)
    GO_annotation (16)
    Structured_description: Concise_description: lin-4 encodes a small non-coding temporal RNA (stRNA); lin-4 activity is required for regulating the timing of fate specification in neuronal and hypodermal lineages during postembryonic development; in the hypodermis, lin-4 represses translation of the lin-14 and lin-28 mRNAs, and in the ventral nerve cord, lin-4 regulates the expression of hbl-1 mRNA; in vitro, lin-4 binds the lin-14 mRNA 3' UTR to form an RNA duplex; lin-4 expression is temporally regulated, beginning at the end of the L1 larval stage and increasing to highest levels in adult animals; lin-4 is conserved in mammals and Drosophila, where it is known as miR-125. Paper_evidence: WBPaper00000496
            WBPaper00002609
            WBPaper00002728
            WBPaper00003583
            WBPaper00005159
            WBPaper00005825
            WBPaper00005909
          Curator_confirmed: WBPerson1843
          Date_last_updated: 18 Aug 2008 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in several processes, including egg-laying behavior; mating; and negative regulation of gene expression. Part of polysome. Expressed in several structures, including P5.p hermaphrodite; P7.p hermaphrodite; gonad; neurons; and ventral nerve cord. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_transcript: F59G1.6
      F59G1.6a
      F59G1.6b
    Associated_feature: WBsf034324
      WBsf977968 Paper_evidence: WBPaper00044681
      WBsf979102
    Gene_product_binds: WBsf019183
      WBsf019184
      WBsf132693
  Experimental_info: Expr_pattern (14)
    Drives_construct: WBCnstr00000927
      WBCnstr00000928
      WBCnstr00004691
      WBCnstr00005149
      WBCnstr00005518
      WBCnstr00007615
      WBCnstr00015029
      WBCnstr00016040
      WBCnstr00019505
      WBCnstr00020503
    Construct_product: WBCnstr00000927
      WBCnstr00000928
      WBCnstr00007618
      WBCnstr00007620
      WBCnstr00007623
      WBCnstr00016930
    Regulate_expr_cluster: WBPaper00026952:class_A
      WBPaper00026952:class_B
      WBPaper00026952:class_C
      WBPaper00026952:class_D
      WBPaper00026952:class_E
      WBPaper00026952:class_F
      WBPaper00026952:class_G
      WBPaper00026952:class_H
    Expression_cluster (16)
    Interaction (158)
    WBProcess: WBbiopr:00000031
      WBbiopr:00000057
      WBbiopr:00000081
      WBbiopr:00000083
  Map_info: Map: II Position: -0.85522 Error: 0.001406
    Well_ordered
    Positive: Inside_rearr: arDp2
      Positive_clone: C02B6
        F59G1 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: ccDf5
    Mapping_data: 2_point: 40
        777
        4220
      Multi_point (15)
      Pos_neg_data: 3708
        4223
        4224
        5921
        9121
        10365
    Landmark_gene
  Reference: WBPaper00000178
    WBPaper00000496
    WBPaper00000500
    WBPaper00000507
    WBPaper00000523
    WBPaper00000544
    WBPaper00000608
    WBPaper00000620
    WBPaper00000672
    WBPaper00000762
    WBPaper00000957
    WBPaper00001002
    WBPaper00001057
    WBPaper00001144
    WBPaper00001244
    WBPaper00001292
    WBPaper00001397
    WBPaper00001435
    WBPaper00001446
    WBPaper00001467
    WBPaper00001468
    WBPaper00001500
    WBPaper00001578
    WBPaper00001655
    WBPaper00001706
    WBPaper00001760
    WBPaper00001829
    WBPaper00001848
    WBPaper00001849
    WBPaper00001867
    WBPaper00002123
    WBPaper00002205
    WBPaper00002222
    WBPaper00002223
    WBPaper00002322
    WBPaper00002362
    WBPaper00002412
    WBPaper00002521
    WBPaper00002609
    WBPaper00002634
    WBPaper00002728
    WBPaper00002970
    WBPaper00003064
    WBPaper00003119
    WBPaper00003201
    WBPaper00003301
    WBPaper00003377
    WBPaper00003403
    WBPaper00003583
    WBPaper00003729
    WBPaper00003838
    WBPaper00003929
    WBPaper00003931
    WBPaper00004231
    WBPaper00004399
    WBPaper00004440
    WBPaper00004463
    WBPaper00004497
    WBPaper00004772
    WBPaper00004927
    WBPaper00004928
    WBPaper00005046
    WBPaper00005105
    WBPaper00005159
    WBPaper00005192
    WBPaper00005201
    WBPaper00005210
    WBPaper00005458
    WBPaper00005499
    WBPaper00005601
    WBPaper00005825
    WBPaper00005879
    WBPaper00005908
    WBPaper00005909
    WBPaper00005947
    WBPaper00005964
    WBPaper00005971
    WBPaper00005974
    WBPaper00006016
    WBPaper00006019
    WBPaper00006077
    WBPaper00006259
    WBPaper00006293
    WBPaper00006345
    WBPaper00006373
    WBPaper00006376
    WBPaper00010151
    WBPaper00010162
    WBPaper00010172
    WBPaper00010280
    WBPaper00010456
    WBPaper00010489
    WBPaper00010536
    WBPaper00010549
    WBPaper00010674
    WBPaper00010680
    WBPaper00010716
    WBPaper00010877
    WBPaper00010918
    WBPaper00010936
    WBPaper00010973
    WBPaper00011001
    WBPaper00011012
    WBPaper00011013
    WBPaper00011033
    WBPaper00011058
    WBPaper00011068
    WBPaper00011121
    WBPaper00011239
    WBPaper00011254
    WBPaper00011370
    WBPaper00012408
    WBPaper00012566
    WBPaper00012605
    WBPaper00012643
    WBPaper00012655
    WBPaper00012664
    WBPaper00012681
    WBPaper00013286
    WBPaper00013395
    WBPaper00013917
    WBPaper00013918
    WBPaper00014070
    WBPaper00014071
    WBPaper00014080
    WBPaper00014111
    WBPaper00014165
    WBPaper00014192
    WBPaper00014199
    WBPaper00014220
    WBPaper00014335
    WBPaper00014384
    WBPaper00014480
    WBPaper00014557
    WBPaper00014588
    WBPaper00014590
    WBPaper00014638
    WBPaper00014915
    WBPaper00014966
    WBPaper00015098
    WBPaper00015101
    WBPaper00015188
    WBPaper00015201
    WBPaper00015363
    WBPaper00015365
    WBPaper00015404
    WBPaper00015416
    WBPaper00015418
    WBPaper00015440
    WBPaper00015492
    WBPaper00015526
    WBPaper00015615
    WBPaper00015978
    WBPaper00016053
    WBPaper00016093
    WBPaper00016094
    WBPaper00016098
    WBPaper00016194
    WBPaper00016254
    WBPaper00016473
    WBPaper00016949
    WBPaper00017124
    WBPaper00017132
    WBPaper00017286
    WBPaper00017778
    WBPaper00017895
    WBPaper00018310
    WBPaper00018441
    WBPaper00018442
    WBPaper00018445
    WBPaper00018446
    WBPaper00018449
    WBPaper00018451
    WBPaper00018869
    WBPaper00018980
    WBPaper00018981
    WBPaper00019003
    WBPaper00019035
    WBPaper00019291
    WBPaper00019487
    WBPaper00019499
    WBPaper00019531
    WBPaper00019532
    WBPaper00019534
    WBPaper00019535
    WBPaper00019714
    WBPaper00020760
    WBPaper00020777
    WBPaper00020855
    WBPaper00020865
    WBPaper00020926
    WBPaper00020927
    WBPaper00020928
    WBPaper00021120
    WBPaper00021688
    WBPaper00021764
    WBPaper00021804
    WBPaper00021831
    WBPaper00021976
    WBPaper00022013
    WBPaper00022041
    WBPaper00022059
    WBPaper00022161
    WBPaper00022194
    WBPaper00022206
    WBPaper00022319
    WBPaper00022329
    WBPaper00022569
    WBPaper00022607
    WBPaper00022711
    WBPaper00022939
    WBPaper00022955
    WBPaper00023149
    WBPaper00023185
    WBPaper00023502
    WBPaper00023625
    WBPaper00023916
    WBPaper00024225
    WBPaper00024416
    WBPaper00024433
    WBPaper00024529
    WBPaper00025125
    WBPaper00025288
    WBPaper00025316
    WBPaper00025457
    WBPaper00025709
    WBPaper00025817
    WBPaper00026043
    WBPaper00026085
    WBPaper00026198
    WBPaper00026424
    WBPaper00026426
    WBPaper00026443
    WBPaper00026508
    WBPaper00026716
    WBPaper00026761
    WBPaper00026780
    WBPaper00026781
    WBPaper00026854
    WBPaper00026999
    WBPaper00027236
    WBPaper00027281
    WBPaper00027282
    WBPaper00027286
    WBPaper00027316
    WBPaper00027347
    WBPaper00027806
    WBPaper00027871
    WBPaper00027913
    WBPaper00028283
    WBPaper00028344
    WBPaper00028857
    WBPaper00028975
    WBPaper00029018
    WBPaper00029151
    WBPaper00029208
    WBPaper00029397
    WBPaper00030505
    WBPaper00030584
    WBPaper00031224
    WBPaper00031252
    WBPaper00031335
    WBPaper00031488
    WBPaper00031556
    WBPaper00031747
    WBPaper00031777
    WBPaper00031984
    WBPaper00032086
    WBPaper00032117
    WBPaper00032160
    WBPaper00032187
    WBPaper00032230
    WBPaper00032329
    WBPaper00032458
    WBPaper00032489
    WBPaper00032548
    WBPaper00032670
    WBPaper00032672
    WBPaper00033038
    WBPaper00033044
    WBPaper00033061
    WBPaper00033132
    WBPaper00033207
    WBPaper00033270
    WBPaper00033679
    WBPaper00033680
    WBPaper00033745
    WBPaper00033821
    WBPaper00033829
    WBPaper00034333
    WBPaper00034339
    WBPaper00034562
    WBPaper00034854
    WBPaper00034907
    WBPaper00035168
    WBPaper00035316
    WBPaper00035431
    WBPaper00035664
    WBPaper00036027
    WBPaper00036067
    WBPaper00036182
    WBPaper00036316
    WBPaper00036334
    WBPaper00036532
    WBPaper00036657
    WBPaper00036764
    WBPaper00036766
    WBPaper00037475
    WBPaper00037551
    WBPaper00037676
    WBPaper00037702
    WBPaper00038300
    WBPaper00038356
    WBPaper00038459
    WBPaper00038504
    WBPaper00038534
    WBPaper00038902
    WBPaper00039005
    WBPaper00039200
    WBPaper00039546
    WBPaper00039549
    WBPaper00039556
    WBPaper00039557
    WBPaper00039767
    WBPaper00039801
    WBPaper00039813
    WBPaper00040016
    WBPaper00040065
    WBPaper00040098
    WBPaper00040197
    WBPaper00040322
    WBPaper00041123
    WBPaper00041184
    WBPaper00041361
    WBPaper00041416
    WBPaper00041520
    WBPaper00042343
    WBPaper00042602
    WBPaper00042642
    WBPaper00043623
    WBPaper00043701
    WBPaper00043713
    WBPaper00043851
    WBPaper00043989
    WBPaper00044188
    WBPaper00044218
    WBPaper00044404
    WBPaper00044603
    WBPaper00044681
    WBPaper00045070
    WBPaper00045275
    WBPaper00045501
    WBPaper00045551
    WBPaper00045911
    WBPaper00046160
    WBPaper00046295
    WBPaper00046619
    WBPaper00047238
    WBPaper00047433
    WBPaper00047435
    WBPaper00048181
    WBPaper00048557
    WBPaper00048656
    WBPaper00048898
    WBPaper00049076
    WBPaper00049710
    WBPaper00049810
    WBPaper00050278
    WBPaper00050411
    WBPaper00052134
    WBPaper00052242
    WBPaper00053065
    WBPaper00053544
    WBPaper00053563
    WBPaper00053576
    WBPaper00054709
    WBPaper00054944
    WBPaper00056201
    WBPaper00056761
    WBPaper00057033
    WBPaper00057461
    WBPaper00058034
    WBPaper00058124
    WBPaper00058145
    WBPaper00059873
    WBPaper00061199
    WBPaper00061289
    WBPaper00061983
    WBPaper00062103
    WBPaper00062143
    WBPaper00063182
    WBPaper00063196
    WBPaper00063201
    WBPaper00063346
    WBPaper00063453
    WBPaper00064592
    WBPaper00065168
    WBPaper00065736
    WBPaper00065859
    WBPaper00065936
  Remark: Rfam accession number: MI0000002
  Method: Gene