WormBase Tree Display for Gene: WBGene00002996
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| WBGene00002996 | SMap | S_parent | Sequence | Y54G11A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-7 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y54G11A.10 | ||||||||
| Molecular_name | Y54G11A.10a | ||||||||
| Y54G11A.10a.1 | |||||||||
| CE43589 | |||||||||
| Y54G11A.10b | |||||||||
| CE43616 | |||||||||
| Y54G11A.10b.1 | |||||||||
| Other_name | CELE_Y54G11A.10 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | lin-7 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00002996 | |||||
| SignaLink | protein | WBGene00002996 | |||||||
| WormFlux | gene | WBGene00002996 | |||||||
| NDB | locus_tag | CELE_Y54G11A.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002996|UniProtKB=A5PEX5 | |||||||
| family | PTHR14063 | ||||||||
| NCBI | gene | 175089 | |||||||
| RefSeq | protein | NM_064581.4 | |||||||
| NM_001129192.6 | |||||||||
| TREEFAM | TREEFAM_ID | TF316850 | |||||||
| TrEMBL | UniProtAcc | A5PEX5 | |||||||
| Q9U245 | |||||||||
| UniProt_GCRP | UniProtAcc | A5PEX5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 06 Mar 2009 10:15:15 | WBPerson1983 | Event | Split_into | WBGene00185067 | ||||
| Split_into | WBGene00185067 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00143988 | ||||||||
| Allele (113) | |||||||||
| Possibly_affected_by | WBVar02157230 | ||||||||
| Legacy_information | e1413amber : adult hermaphrodite vulvaless (penetrance 98%) HME2; adult male wildtype ME3. NA13 (e974amber n308 (both resemble e1413) n308cs (penetrance 95% at 15x 28% at 25x) etc.). | ||||||||
| See also e974, e1413, e1449, n106, n308, n384, n385, n673, n701, n759, n760, n763, n764 | |||||||||
| [C.elegansII] e1413amb : adult hermaphrodite vulvaless (penetrance 98%) HME2; adult male wildtype ME3. OA>10: e974amb, n308 (both resemble e1413), n308cs (penetrance 95% at 15C 28% at 25C), n385, n764 etc. Cloned: encodes predicted 33kD protein withPDZ domain, similarity to junction-associated proteins. Mutants delocalize LET-23. [Sulston and Horvitz 1981; MT; SD] | |||||||||
| Strain | WBStrain00026701 | ||||||||
| WBStrain00026719 | |||||||||
| WBStrain00036118 | |||||||||
| WBStrain00004327 | |||||||||
| WBStrain00004334 | |||||||||
| WBStrain00004774 | |||||||||
| WBStrain00005495 | |||||||||
| WBStrain00031251 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Contained_in_operon | CEOP2636 | ||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00014100 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Structured_description | Concise_description | lin-7 encodes a protein that contains a PDZ domain and an L27 domain, two protein interaction domains that likely serve as organizational centers for large macromolecular complexes in polarized cells; LIN-7 is required for proper basolateral localization of the LET-23/EGF receptor in vulval epithelial cells, and along with LIN-2 and LIN-10, forms a protein complex that likely mediates this asymmetric localization with LIN-7 simultaneously binding to the C-terminus of LET-23 and an internal region of LIN-2; a LIN-7 translational reporter fusion indicates that LIN-7 is expressed at intestinal cell junctions; expression in vulval epithelial cells is detected only upon overexpression via heat shock, and reveals localization primarily at the lateral cell junctions of the vulval precursor cells P5.p and P6.p | Paper_evidence | WBPaper00000496 | |||||
| WBPaper00002436 | |||||||||
| WBPaper00003215 | |||||||||
| WBPaper00006521 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 01 Feb 2006 00:00:00 | ||||||||
| Automated_description | Enables protein-macromolecule adaptor activity and signaling receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to basolateral plasma membrane. Located in cell-cell junction. Expressed in gonad; head; somatic gonad precursor; somatic nervous system; and vulval precursor cell. Is an ortholog of human LIN7A (lin-7 homolog A, crumbs cell polarity complex component); LIN7B (lin-7 homolog B, crumbs cell polarity complex component); and LIN7C (lin-7 homolog C, crumbs cell polarity complex component). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y54G11A.10a | |||||||
| Y54G11A.10b | |||||||||
| Corresponding_CDS_history | Y54G11A.10:wp52 | ||||||||
| Y54G11A.10a:wp201 | |||||||||
| Y54G11A.10b:wp201 | |||||||||
| Corresponding_transcript | Y54G11A.10a.1 | ||||||||
| Y54G11A.10b.1 | |||||||||
| Other_sequence (34) | |||||||||
| Associated_feature | WBsf650744 | ||||||||
| WBsf224266 | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr690 | ||||||||
| Expr15957 | |||||||||
| Expr15960 | |||||||||
| Expr15963 | |||||||||
| Expr1021328 | |||||||||
| Expr1031393 | |||||||||
| Expr1160856 | |||||||||
| Expr2013200 | |||||||||
| Expr2031432 | |||||||||
| Drives_construct | WBCnstr00000521 | ||||||||
| WBCnstr00012493 | |||||||||
| WBCnstr00036298 | |||||||||
| Construct_product | WBCnstr00000520 | ||||||||
| WBCnstr00000720 | |||||||||
| WBCnstr00012493 | |||||||||
| WBCnstr00036298 | |||||||||
| Antibody | WBAntibody00000108 | ||||||||
| WBAntibody00000109 | |||||||||
| WBAntibody00000974 | |||||||||
| WBAntibody00001092 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (128) | |||||||||
| Map_info | Map | II | Position | 22.9062 | Error | 0.001213 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y54G11A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | 2_point | 493 | |||||||
| 3926 | |||||||||
| 4226 | |||||||||
| 4227 | |||||||||
| 5206 | |||||||||
| 5209 | |||||||||
| 5210 | |||||||||
| Multi_point (15) | |||||||||
| Pos_neg_data | 4213 | ||||||||
| 4438 | |||||||||
| 4508 | |||||||||
| 4509 | |||||||||
| 4510 | |||||||||
| Reference (138) | |||||||||
| Method | Gene |
