WormBase Tree Display for Gene: WBGene00003008

WBGene00003008 SMap: S_parent: Sequence: Y54G2A
  Identity: Version: 1
    Name: CGC_name: lin-22 Person_evidence: WBPerson261
      Sequence_name: Y54G2A.1
      Molecular_name: Y54G2A.1
        Y54G2A.1.1
        CE26703
      Other_name: hlh-9 Person_evidence: WBPerson346
        4D656 Accession_evidence: EMBL AF304120
        CELE_Y54G2A.1 Accession_evidence: NDB BX284604
      Public_name: lin-22
    DB_info: Database: AceView gene 4D787
        WormQTL gene WBGene00003008
        WormFlux gene WBGene00003008
        NDB locus_tag CELE_Y54G2A.1
        Panther gene CAEEL|WormBase=WBGene00003008|UniProtKB=G5EF76
          family PTHR10985
        NCBI gene 177082
        RefSeq protein NM_067880.6
        SwissProt UniProtAcc G5EF76
        UniProt_GCRP UniProtAcc G5EF76
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00089461
    Allele: WBVar00600765 Inferred_automatically: From strain object: CF26
      WBVar00089196 Inferred_automatically: From strain object: CF31
      WBVar00094953 Inferred_automatically: From strain object: OH4265
      WBVar02149844 Inferred_automatically: From strain object: OH4270
      WBVar00094954 Inferred_automatically: From strain object: OH4271
      WBVar00094963 Inferred_automatically: From strain object: OH4320
      WBVar00089963
      WBVar02147287
      WBVar02147289
      WBVar02147288
      WBVar00089271
      WBVar02157975
      WBVar02157976
      WBVar00896151
      WBVar00896152
      WBVar00896153
      WBVar00896154
      WBVar00896155
      WBVar00896156
      WBVar00896157
      WBVar00896158
      WBVar00896159
      WBVar00896160
      WBVar00896161
      WBVar00896162
      WBVar00896163
      WBVar00896164
      WBVar00896165
      WBVar00896166
      WBVar00896167
      WBVar00896168
      WBVar01965629
      WBVar01451540
      WBVar01965630
      WBVar01451541
      WBVar02020268
      WBVar01451542
      WBVar01965631
      WBVar01451543
      WBVar01489052
      WBVar01965632
      WBVar01451544
      WBVar01451545
      WBVar01451546
      WBVar01630144
      WBVar01630145
      WBVar02094318
      WBVar00186687
      WBVar00186688
      WBVar00420421
      WBVar00420422
      WBVar00186689
      WBVar00186690
      WBVar00420423
      WBVar00420424
      WBVar00420425
      WBVar01481528
      WBVar00420426
      WBVar01514160
      WBVar01481529
      WBVar00420427
      WBVar01481530
      WBVar00420428
      WBVar01481531
      WBVar00420429
      WBVar01481532
      WBVar00089461
      WBVar01498316
      WBVar02031117
      WBVar01580567
      WBVar01499633
      WBVar00896148
      WBVar00896149
      WBVar00896150
    Legacy_information: n372 : V1-V4 divide like V5 resulting in multiple ectopic postdeirids in hermaphrodites and males and multiple ectopic rays in males. Males also have hermaphroditic Pn.p's and are mostly missing lateral alae. ES1 (hermaphrodite) ES2 (male). ME2. NA1.
      See also n372, n1113
    Strain (12)
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (25)
    Paralog: WBGene00001964 Caenorhabditis elegans From_analysis: Panther
      WBGene00001966 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: lin-22 encodes a basic helix-loop-helix (bHLH)-containing protein that is homologous to the Drosophila hairy/Enhancer of split transcriptional repressors; during postembryonic development, lin-22 activity is required for patterning of midbody epidermal and neuronal lineages. Paper_evidence: WBPaper00000978
            WBPaper00002844
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Aug 2005 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be located in nucleus. Expressed in seam cell. Human ortholog(s) of this gene implicated in hemangiopericytoma. Is an ortholog of human HES1 (hes family bHLH transcription factor 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:264 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5192)
  Molecular_info: Corresponding_CDS: Y54G2A.1
    Corresponding_transcript: Y54G2A.1.1
    Other_sequence: EX916391.1
      Hbac_isotig05734
      EG025731.1
      HBC05050_1
      HBC04228_1
    Associated_feature: WBsf660013
      WBsf718055
      WBsf718056
      WBsf978797
      WBsf1026934
      WBsf1026935
      WBsf1026936
    Transcription_factor: WBTranscriptionFactor000727
  Experimental_info: RNAi_result: WBRNAi00057436 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00004218
      WBCnstr00036289
      WBCnstr00039720
      WBCnstr00039721
      WBCnstr00039722
      WBCnstr00039723
    Construct_product: WBCnstr00016691
      WBCnstr00016896
      WBCnstr00036289
    Regulate_expr_cluster: WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053295:lin-22(ot269)_upregulated
    Microarray_results (22)
    Expression_cluster (67)
    Interaction: WBInteraction000001026
      WBInteraction000001027
      WBInteraction000001592
      WBInteraction000003146
      WBInteraction000003346
      WBInteraction000003359
      WBInteraction000003387
      WBInteraction000008720
      WBInteraction000008721
      WBInteraction000008722
      WBInteraction000009321
      WBInteraction000009467
      WBInteraction000009476
      WBInteraction000009636
      WBInteraction000028818
      WBInteraction000028873
      WBInteraction000029393
      WBInteraction000029394
      WBInteraction000029732
      WBInteraction000029733
      WBInteraction000029734
      WBInteraction000032831
      WBInteraction000033944
      WBInteraction000033978
      WBInteraction000034377
      WBInteraction000035360
      WBInteraction000036327
      WBInteraction000036346
      WBInteraction000036628
      WBInteraction000036745
      WBInteraction000036858
      WBInteraction000038605
      WBInteraction000039045
      WBInteraction000039047
      WBInteraction000039049
      WBInteraction000039863
      WBInteraction000040413
      WBInteraction000040801
      WBInteraction000041321
      WBInteraction000042734
      WBInteraction000043137
      WBInteraction000043492
      WBInteraction000043547
      WBInteraction000043555
      WBInteraction000043993
      WBInteraction000044367
      WBInteraction000044418
      WBInteraction000044449
      WBInteraction000044832
      WBInteraction000044833
      WBInteraction000044834
      WBInteraction000044843
      WBInteraction000045358
      WBInteraction000045402
      WBInteraction000046005
      WBInteraction000046006
      WBInteraction000048447
      WBInteraction000048691
      WBInteraction000049078
      WBInteraction000049262
      WBInteraction000049725
      WBInteraction000114619
      WBInteraction000122596
      WBInteraction000126205
      WBInteraction000126401
      WBInteraction000127353
      WBInteraction000133171
      WBInteraction000133643
      WBInteraction000135836
      WBInteraction000151163
      WBInteraction000165172
      WBInteraction000165173
      WBInteraction000166021
      WBInteraction000166850
      WBInteraction000173360
      WBInteraction000173635
      WBInteraction000174331
      WBInteraction000196881
      WBInteraction000215128
      WBInteraction000233001
      WBInteraction000238806
      WBInteraction000238808
      WBInteraction000245421
      WBInteraction000256886
      WBInteraction000279236
      WBInteraction000300523
      WBInteraction000339819
      WBInteraction000351279
      WBInteraction000351282
      WBInteraction000360730
      WBInteraction000465743
      WBInteraction000501085
      WBInteraction000501425
      WBInteraction000562985
      WBInteraction000569421
      WBInteraction000578672
      WBInteraction000580136
      WBInteraction000581364
      WBInteraction000582063
      WBInteraction000582718
      WBInteraction000586633
  Map_info: Map: IV Position: -6.65585 Error: 0.044343
    Well_ordered
    Positive: Positive_clone: Y54G2A Inferred_automatically: From sequence, transcript, pseudogene data
        Y94H6
    Mapping_data: Multi_point: 683
        684
        691
  Reference (147)
  Remark: The attached sequence (Y54G2A.1) was previously connected to him-5 by mistake [030212 krb]
  Method: Gene