WormBase Tree Display for Gene: WBGene00003008

WBGene00003008 SMap: S_parent: Sequence: Y54G2A
  Identity: Version: 1
    Name: CGC_name: lin-22 Person_evidence: WBPerson261
      Sequence_name: Y54G2A.1
      Molecular_name: Y54G2A.1
        Y54G2A.1.1
        CE26703
      Other_name: hlh-9 Person_evidence: WBPerson346
        4D656 Accession_evidence: EMBL AF304120
        CELE_Y54G2A.1 Accession_evidence: NDB BX284604
      Public_name: lin-22
    DB_info: Database: AceView gene 4D787
        WormQTL gene WBGene00003008
        WormFlux gene WBGene00003008
        NDB locus_tag CELE_Y54G2A.1
        Panther gene CAEEL|WormBase=WBGene00003008|UniProtKB=G5EF76
          family PTHR10985
        NCBI gene 177082
        RefSeq protein NM_067880.6
        SwissProt UniProtAcc G5EF76
        UniProt_GCRP UniProtAcc G5EF76
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00089461
    Allele (74)
    Legacy_information: n372 : V1-V4 divide like V5 resulting in multiple ectopic postdeirids in hermaphrodites and males and multiple ectopic rays in males. Males also have hermaphroditic Pn.p's and are mostly missing lateral alae. ES1 (hermaphrodite) ES2 (male). ME2. NA1.
      See also n372, n1113
    Strain (12)
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (25)
    Paralog: WBGene00001964 Caenorhabditis elegans From_analysis: Panther
      WBGene00001966 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: lin-22 encodes a basic helix-loop-helix (bHLH)-containing protein that is homologous to the Drosophila hairy/Enhancer of split transcriptional repressors; during postembryonic development, lin-22 activity is required for patterning of midbody epidermal and neuronal lineages. Paper_evidence: WBPaper00000978
            WBPaper00002844
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Aug 2005 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be located in nucleus. Expressed in seam cell. Human ortholog(s) of this gene implicated in hemangiopericytoma. Is an ortholog of human HES1 (hes family bHLH transcription factor 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:264 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5192)
  Molecular_info: Corresponding_CDS: Y54G2A.1
    Corresponding_transcript: Y54G2A.1.1
    Other_sequence: EX916391.1
      Hbac_isotig05734
      EG025731.1
      HBC05050_1
      HBC04228_1
    Associated_feature: WBsf660013
      WBsf718055
      WBsf718056
      WBsf978797
      WBsf1026934
      WBsf1026935
      WBsf1026936
    Transcription_factor: WBTranscriptionFactor000727
  Experimental_info: RNAi_result: WBRNAi00057436 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00004218
      WBCnstr00036289
      WBCnstr00039720
      WBCnstr00039721
      WBCnstr00039722
      WBCnstr00039723
    Construct_product: WBCnstr00016691
      WBCnstr00016896
      WBCnstr00036289
    Regulate_expr_cluster: WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053295:lin-22(ot269)_upregulated
    Microarray_results (22)
    Expression_cluster: WBPaper00032528:L3_depleted
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1(gv6)_upregulated_embryo_protein
      WBPaper00056826:SGP_biased
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058886:anp-1(ok608)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:sre-33-ZK1025.1_8337
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065331:100nM-ivermectin_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065841:0_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00036286:Pattern_H
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037113:Diazinon_16C_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00041939:control_vs_EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00055899:nitroguanidine_regulated
    Interaction (101)
  Map_info: Map: IV Position: -6.65585 Error: 0.044343
    Well_ordered
    Positive: Positive_clone: Y54G2A Inferred_automatically: From sequence, transcript, pseudogene data
        Y94H6
    Mapping_data: Multi_point: 683
        684
        691
  Reference (147)
  Remark: The attached sequence (Y54G2A.1) was previously connected to him-5 by mistake [030212 krb]
  Method: Gene