WormBase Tree Display for Gene: WBGene00003030
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| WBGene00003030 | SMap | S_parent | Sequence | Y73B6A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-45 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y73B6A.5 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | raf-1 | ||||||||
| CELE_Y73B6A.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | lin-45 | ||||||||
| DB_info | Database (15) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Allele (107) | |||||||||
| Legacy_information | [C.elegansII] sy96 : subviable, >90% die as rod-like L1, escapers mostly Egl, Vul; suppresses lin-15Muv; impenetrant P12 to P11 transformation; partial maternal rescue of larval lethality. Effects on male development resemble F and U ablation. OA1: n2018cs (most animals vulvaless or inviable at 15C; 25% non-Vul at 25C). Cloned: pka raf-1, encodes 813 aa predicted protein with extensive similarity to raf kinases. Dominant negative transgene frequently Vul. [Han et al. 1993; MH; MT; PS] | ||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Contained_in_operon | CEOP4192 | ||||||||
| Ortholog (39) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | The lin-45 gene encodes an ortholog of the vertebrate protein RAF which is required for larval viability, fertility and the induction of vulval cell fates. | Paper_evidence | WBPaper00005135 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables small GTPase binding activity. Involved in several processes, including defense response to Gram-positive bacterium; intracellular signal transduction; and vulval development. Expressed in head neurons and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome with multiple lentigines (multiple); carcinoma (multiple); and central nervous system benign neoplasm (multiple). Is an ortholog of human BRAF (B-Raf proto-oncogene, serine/threonine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (29) | ||||||||
| Molecular_info | Corresponding_CDS | Y73B6A.5a | |||||||
| Y73B6A.5b | |||||||||
| Y73B6A.5c | |||||||||
| Y73B6A.5d | |||||||||
| Y73B6A.5e | |||||||||
| Y73B6A.5f | |||||||||
| Corresponding_transcript | Y73B6A.5a.1 | ||||||||
| Y73B6A.5b.1 | |||||||||
| Y73B6A.5c.1 | |||||||||
| Y73B6A.5d.1 | |||||||||
| Y73B6A.5e.1 | |||||||||
| Y73B6A.5f.1 | |||||||||
| Other_sequence (30) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr263 | ||||||||
| Expr10576 | |||||||||
| Expr1010665 | |||||||||
| Expr1031418 | |||||||||
| Expr1161716 | |||||||||
| Expr2013187 | |||||||||
| Expr2031419 | |||||||||
| Drives_construct | WBCnstr00036275 | ||||||||
| Construct_product (22) | |||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (143) | |||||||||
| Interaction (244) | |||||||||
| Anatomy_function | WBbtf0665 | ||||||||
| WBProcess | WBbiopr:00000020 | ||||||||
| WBbiopr:00000070 | |||||||||
| WBbiopr:00000071 | |||||||||
| Map_info | Map | IV | Position | 3.22833 | Error | 0.001795 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y22D1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Y73B6A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 1641 | |||||||
| 1642 | |||||||||
| 1929 | |||||||||
| 3152 | |||||||||
| 3799 | |||||||||
| 3909 | |||||||||
| 4752 | |||||||||
| Pos_neg_data | 7280 | ||||||||
| Landmark_gene | |||||||||
| Reference (228) | |||||||||
| Picture | WBPicture0000013080 | ||||||||
| Remark | L15347 mtaches Y73B6A.5, hence latter substituted as sequence. [sdm 000917] | ||||||||
| Method | Gene |
