WormBase Tree Display for Gene: WBGene00003036
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| WBGene00003036 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-53 | Person_evidence | WBPerson261 | |||||
| Sequence_name | K07A1.12 | ||||||||
| Molecular_name | K07A1.12 | ||||||||
| K07A1.12.1 | |||||||||
| CE16234 | |||||||||
| Other_name | rba-2 | ||||||||
| CELE_K07A1.12 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lin-53 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Allele (28) | |||||||||
| Legacy_information | [Mello C] rba for Rb binding protein (RbAp48) related. | ||||||||
| Strain | WBStrain00027345 | ||||||||
| WBStrain00027374 | |||||||||
| WBStrain00027474 | |||||||||
| WBStrain00027516 | |||||||||
| WBStrain00027485 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Contained_in_operon | CEOP1552 | ||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00004312 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00008403 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021899 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lin-53 encodes a class B synMuv protein containing a 7 WD-repeat similar to the mammalian homolog RbAp48 (OMIM: 602923), an interaction between LIN-53 and LIN-9 is important for the incorporation of LIN-53 into the DRM complex; a complete loss of LIN-53 disrupts DRM complex formation and result in the degradation of other complex members; Null mutations in lin-53 causes decreases in the protein levels of other DRM complex components, including LIN-9, LIN-37, LIN-52, and LIN-54 for transcriptional repression; LIN-53 is present in both the DRM complex and a NuRD-like complex; LIN-53 remain associated throughout larval development, including the late L2 and early L3 stages when the fates of the Pn.p cells are specified. | Paper_evidence | WBPaper00003329 | |||||
| WBPaper00028573 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 28 Jul 2011 00:00:00 | ||||||||
| Automated_description | Enables histone deacetylase binding activity. Involved in several processes, including cell fate specification; embryonic digestive tract morphogenesis; and nematode male tail tip morphogenesis. Acts upstream of or within mitochondrial unfolded protein response. Located in nucleus. Part of DRM complex and NuRD complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Is an ortholog of human RBBP4 (RB binding protein 4, chromatin remodeling factor) and RBBP7 (RB binding protein 7, chromatin remodeling factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K07A1.12 | |||||||
| Corresponding_transcript | K07A1.12.1 | ||||||||
| Other_sequence (132) | |||||||||
| Associated_feature | WBsf649501 | ||||||||
| WBsf976912 | |||||||||
| WBsf976913 | |||||||||
| WBsf984764 | |||||||||
| WBsf220115 | |||||||||
| WBsf220116 | |||||||||
| Experimental_info | RNAi_result (35) | ||||||||
| Expr_pattern | Expr1292 | ||||||||
| Expr14576 | |||||||||
| Expr15500 | |||||||||
| Expr1019629 | |||||||||
| Expr1031422 | |||||||||
| Expr1153783 | |||||||||
| Expr2013192 | |||||||||
| Expr2031424 | |||||||||
| Drives_construct | WBCnstr00000279 | ||||||||
| WBCnstr00001279 | |||||||||
| WBCnstr00036270 | |||||||||
| Construct_product | WBCnstr00008070 | ||||||||
| WBCnstr00015590 | |||||||||
| WBCnstr00016066 | |||||||||
| WBCnstr00016156 | |||||||||
| WBCnstr00036270 | |||||||||
| Antibody | WBAntibody00001179 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (195) | |||||||||
| Interaction (855) | |||||||||
| Map_info | Map | I | Position | 3.8084 | Error | 0.001029 | |||
| Positive | Positive_clone | K07A1 | Person_evidence | WBPerson419 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4101 | |||||||
| 4118 | |||||||||
| 4119 | |||||||||
| 5375 | |||||||||
| Reference (94) | |||||||||
| Remark | rba-2 gene was merged into lin-53 following advice from J. Hodgkin. 02/06/14 krb. | ||||||||
| data extracted from cgc5861 | CGC_data_submission | ||||||||
| Method | Gene |
