WormBase Tree Display for Gene: WBGene00003056

WBGene00003056 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: lon-2 Person_evidence: WBPerson261
      Sequence_name: C39E6.1
      Molecular_name: C39E6.1
        C39E6.1.1
        CE35426
      Other_name: CELE_C39E6.1 Accession_evidence: NDB BX284606
      Public_name: lon-2
    DB_info: Database: AceView gene XF356
        WormQTL gene WBGene00003056
        WormFlux gene WBGene00003056
        NDB locus_tag CELE_C39E6.1
        Panther gene CAEEL|WormBase=WBGene00003056|UniProtKB=Q18530
          family PTHR10822
        NCBI gene 180750
        RefSeq protein NM_076411.8
        TREEFAM TREEFAM_ID TF353541
        TrEMBL UniProtAcc Q18530
        UniProt_GCRP UniProtAcc Q18530
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lon
    Reference_allele: WBVar00143398
    Allele: WBVar00143398 Inferred_automatically (218)
      WBVar00090138 Inferred_automatically: From strain object: MT3124
      WBVar00143293
      WBVar00143633
      WBVar00145396
      WBVar00143351
      WBVar00143391
      WBVar01878315
      WBVar01142551
      WBVar01142552
      WBVar01526492
      WBVar01878316
      WBVar01142553
      WBVar00502078
      WBVar01878317
      WBVar01142554
      WBVar00502079
      WBVar01878318
      WBVar00502080
      WBVar01878319
      WBVar01142555
      WBVar00502081
      WBVar01878320
      WBVar01142556
      WBVar01142557
      WBVar00502082
      WBVar01878321
      WBVar00502083
      WBVar01878322
      WBVar01142558
      WBVar01830262
      WBVar01878323
      WBVar01830263
      WBVar00502084
      WBVar01142559
      WBVar01142560
      WBVar00502085
      WBVar01830264
      WBVar01878324
      WBVar01142561
      WBVar01830265
      WBVar01878325
      WBVar02151986
      WBVar00502086
      WBVar01142562
      WBVar01878326
      WBVar00502087
      WBVar00502088
      WBVar01142563
      WBVar01878327
      WBVar00502089
      WBVar01601652
      WBVar01878328
      WBVar01142564
      WBVar01878329
      WBVar00502090
      WBVar01601653
      WBVar01142565
      WBVar01878330
      WBVar01142566
      WBVar00502091
      WBVar01878331
      WBVar00502092
      WBVar01142567
      WBVar00502093
      WBVar01142568
      WBVar01878332
      WBVar00502094
      WBVar01142569
      WBVar01878333
      WBVar00502095
      WBVar01142570
      WBVar01142571
      WBVar00502096
      WBVar02063567
      WBVar01142572
      WBVar00502097
      WBVar02063568
      WBVar00502098
      WBVar01142573
      WBVar01142574
      WBVar00502099
      WBVar02063569
      WBVar01142575
      WBVar02063570
      WBVar02063571
      WBVar01142576
      WBVar01142577
      WBVar02063572
      WBVar01142578
      WBVar01142579
      WBVar01142580
      WBVar01142581
      WBVar01142582
      WBVar01142583
      WBVar01142584
      WBVar01142585
      WBVar01142586
      WBVar01909399
      WBVar01142587
      WBVar01142588
      WBVar01142589
      WBVar01142590
      WBVar01142591
      WBVar01142592
      WBVar01486861
      WBVar01142593
      WBVar01142594
      WBVar01486862
      WBVar01486863
      WBVar01142595
      WBVar01142596
      WBVar01486864
      WBVar01142597
      WBVar01142598
      WBVar01142599
      WBVar01142600
      WBVar01710759
      WBVar01142601
      WBVar01710760
      WBVar01142602
      WBVar01142603
      WBVar01710761
      WBVar01142604
      WBVar01710762
      WBVar01710763
      WBVar01142605
      WBVar01142606
      WBVar01710764
      WBVar01142607
      WBVar01710765
      WBVar01499756
      WBVar01499757
      WBVar01710766
      WBVar01142608
      WBVar01142609
      WBVar01710767
      WBVar01710768
      WBVar01945154
      WBVar01142610
      WBVar01710769
      WBVar01142611
      WBVar01142612
      WBVar01710770
      WBVar01142613
      WBVar01710771
      WBVar01142614
      WBVar01710772
      WBVar01417342
      WBVar01142615
      WBVar01897617
      WBVar01710773
      WBVar01710774
      WBVar01142616
      WBVar01710775
      WBVar00144589
      WBVar01834970
      WBVar00265436
      WBVar01468651
      WBVar01468652
      WBVar00255511
      WBVar00256620
      WBVar00090226
      WBVar00307208
      WBVar01980559
      WBVar01980560
      WBVar01980561
      WBVar01980562
      WBVar02050515
      WBVar02050516
      WBVar00144975
      WBVar02144425
      WBVar00143184
      WBVar02015524
      WBVar00078182
      WBVar02015525
      WBVar00078183
      WBVar02015526
      WBVar00078184
      WBVar00078185
      WBVar00078186
      WBVar00078187
      WBVar00143211
      WBVar00078188
      WBVar00078189
      WBVar00078190
      WBVar01498929
      WBVar00078191
      WBVar00078192
      WBVar02070379
      WBVar01500236
      WBVar01500237
      WBVar02116351
      WBVar01142537
      WBVar00243572
      WBVar01142538
      WBVar01142539
      WBVar01142540
      WBVar01142541
      WBVar01142542
      WBVar01142543
      WBVar01142544
      WBVar01142545
      WBVar01142546
      WBVar01142547
      WBVar01878311
      WBVar01142548
      WBVar01878312
      WBVar01878313
      WBVar01142549
      WBVar01500067
      WBVar01878314
      WBVar01142550
    Legacy_information: e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678).
      [C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974]
    Strain (224)
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (25)
    Structured_description: Concise_description: lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. Paper_evidence: WBPaper00029002
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Jan 2007 00:00:00
      Automated_description: Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C39E6.1
    Corresponding_CDS_history: C39E6.1:wp107
    Corresponding_transcript: C39E6.1.1
    Other_sequence: CRC07010_1
      CR09868
      CGC00490_1
      CBC13859_1
      CJC03031_1
      CRC04307_1
    Associated_feature (15)
  Experimental_info: RNAi_result (23)
    Expr_pattern: Expr4651
      Expr4652
      Expr12191
      Expr1011265
      Expr1031435
      Expr1146202
      Expr2013244
      Expr2031475
    Drives_construct: WBCnstr00012150
      WBCnstr00012151
      WBCnstr00021097
      WBCnstr00021479
      WBCnstr00036259
    Construct_product: WBCnstr00012151
      WBCnstr00021471
      WBCnstr00021474
      WBCnstr00021479
      WBCnstr00036259
    Microarray_results (21)
    Expression_cluster (142)
    Interaction (24)
  Map_info: Map: X Position: -6.74013 Error: 0.007834
    Well_ordered
    Positive: Inside_rearr: mnDp30
        yDp4
      Positive_clone: C39E6 Inferred_automatically: From sequence, transcript, pseudogene data
        F43C9
    Negative: Outside_rearr: mcDf2
    Mapping_data: 2_point (57)
      Multi_point (150)
      Pos_neg_data (31)
    Landmark_gene
  Reference (155)
  Remark: sequence wsa incorrectly given as F43C9.3
  Method: Gene