WormBase Tree Display for Gene: WBGene00003056
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| WBGene00003056 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lon-2 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C39E6.1 | ||||||||
| Molecular_name | C39E6.1 | ||||||||
| C39E6.1.1 | |||||||||
| CE35426 | |||||||||
| Other_name | CELE_C39E6.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lon-2 | ||||||||
| DB_info | Database | AceView | gene | XF356 | |||||
| WormQTL | gene | WBGene00003056 | |||||||
| WormFlux | gene | WBGene00003056 | |||||||
| NDB | locus_tag | CELE_C39E6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003056|UniProtKB=Q18530 | |||||||
| family | PTHR10822 | ||||||||
| NCBI | gene | 180750 | |||||||
| RefSeq | protein | NM_076411.8 | |||||||
| TREEFAM | TREEFAM_ID | TF353541 | |||||||
| TrEMBL | UniProtAcc | Q18530 | |||||||
| UniProt_GCRP | UniProtAcc | Q18530 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lon | ||||||||
| Reference_allele | WBVar00143398 | ||||||||
| Allele (213) | |||||||||
| Legacy_information | e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678). | ||||||||
| [C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974] | |||||||||
| Strain (224) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (25) | |||||||||
| Structured_description | Concise_description | lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. | Paper_evidence | WBPaper00029002 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jan 2007 00:00:00 | ||||||||
| Automated_description | Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C39E6.1 | |||||||
| Corresponding_CDS_history | C39E6.1:wp107 | ||||||||
| Corresponding_transcript | C39E6.1.1 | ||||||||
| Other_sequence | CRC07010_1 | ||||||||
| CR09868 | |||||||||
| CGC00490_1 | |||||||||
| CBC13859_1 | |||||||||
| CJC03031_1 | |||||||||
| CRC04307_1 | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr4651 | ||||||||
| Expr4652 | |||||||||
| Expr12191 | |||||||||
| Expr1011265 | |||||||||
| Expr1031435 | |||||||||
| Expr1146202 | |||||||||
| Expr2013244 | |||||||||
| Expr2031475 | |||||||||
| Drives_construct | WBCnstr00012150 | ||||||||
| WBCnstr00012151 | |||||||||
| WBCnstr00021097 | |||||||||
| WBCnstr00021479 | |||||||||
| WBCnstr00036259 | |||||||||
| Construct_product | WBCnstr00012151 | ||||||||
| WBCnstr00021471 | |||||||||
| WBCnstr00021474 | |||||||||
| WBCnstr00021479 | |||||||||
| WBCnstr00036259 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (142) | |||||||||
| Interaction (24) | |||||||||
| Map_info | Map | X | Position | -6.74013 | Error | 0.007834 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDp30 | |||||||
| yDp4 | |||||||||
| Positive_clone | C39E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| F43C9 | |||||||||
| Negative | Outside_rearr | mcDf2 | |||||||
| Mapping_data | 2_point (57) | ||||||||
| Multi_point (150) | |||||||||
| Pos_neg_data | 935 | ||||||||
| 1859 | |||||||||
| 1888 | |||||||||
| 1912 | |||||||||
| 1928 | |||||||||
| 1944 | |||||||||
| 1960 | |||||||||
| 1976 | |||||||||
| 1992 | |||||||||
| 2019 | |||||||||
| 2040 | |||||||||
| 2051 | |||||||||
| 2058 | |||||||||
| 2174 | |||||||||
| 2175 | |||||||||
| 2178 | |||||||||
| 2362 | |||||||||
| 5453 | |||||||||
| 5834 | |||||||||
| 4564 | |||||||||
| 8420 | |||||||||
| 8422 | |||||||||
| 8429 | |||||||||
| 8433 | |||||||||
| 8441 | |||||||||
| 8446 | |||||||||
| 8450 | |||||||||
| 8456 | |||||||||
| 8475 | |||||||||
| 10694 | |||||||||
| 10695 | |||||||||
| Landmark_gene | |||||||||
| Reference (155) | |||||||||
| Remark | sequence wsa incorrectly given as F43C9.3 | ||||||||
| Method | Gene |
