WormBase Tree Display for Gene: WBGene00003056
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WBGene00003056 | SMap | S_parent | Sequence | CHROMOSOME_X | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | lon | |||||
Reference_allele | WBVar00143398 | |||||
Allele (213) | ||||||
Legacy_information | e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678). | |||||
[C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974] | ||||||
Strain (224) | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (19) | ||||||
Ortholog (25) | ||||||
Structured_description | Concise_description | lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. | Paper_evidence | WBPaper00029002 | ||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 24 Jan 2007 00:00:00 | |||||
Automated_description | Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | C39E6.1 | ||||
Corresponding_CDS_history | C39E6.1:wp107 | |||||
Corresponding_transcript | C39E6.1.1 | |||||
Other_sequence | CRC07010_1 | |||||
CR09868 | ||||||
CGC00490_1 | ||||||
CBC13859_1 | ||||||
CJC03031_1 | ||||||
CRC04307_1 | ||||||
Associated_feature (15) | ||||||
Experimental_info | RNAi_result (23) | |||||
Expr_pattern | Expr4651 | |||||
Expr4652 | ||||||
Expr12191 | ||||||
Expr1011265 | ||||||
Expr1031435 | ||||||
Expr1146202 | ||||||
Expr2013244 | ||||||
Expr2031475 | ||||||
Drives_construct (5) | ||||||
Construct_product | WBCnstr00012151 | |||||
WBCnstr00021471 | ||||||
WBCnstr00021474 | ||||||
WBCnstr00021479 | ||||||
WBCnstr00036259 | ||||||
Microarray_results (21) | ||||||
Expression_cluster (142) | ||||||
Interaction (24) | ||||||
Map_info (6) | ||||||
Reference (155) | ||||||
Remark | sequence wsa incorrectly given as F43C9.3 | |||||
Method | Gene |