WormBase Tree Display for Gene: WBGene00003071
expand all nodes | collapse all nodes | view schema
| WBGene00003071 | SMap | S_parent | Sequence | F29D11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lrp-1 | Person_evidence | WBPerson220 | |||||
| Sequence_name | F29D11.1 | ||||||||
| Molecular_name | F29D11.1 | ||||||||
| F29D11.1.1 | |||||||||
| CE05765 | |||||||||
| Other_name | egf-4 | ||||||||
| CELE_F29D11.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lrp-1 | ||||||||
| DB_info | Database | AceView | gene | 1I209 | |||||
| WormQTL | gene | WBGene00003071 | |||||||
| WormFlux | gene | WBGene00003071 | |||||||
| NDB | locus_tag | CELE_F29D11.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003071|UniProtKB=Q04833 | |||||||
| family | PTHR24270 | ||||||||
| NCBI | gene | 172520 | |||||||
| RefSeq | protein | NM_001392587.1 | |||||||
| SwissProt | UniProtAcc | Q04833 | |||||||
| UniProt_GCRP | UniProtAcc | Q04833 | |||||||
| OMIM | gene | 600073 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lrp | ||||||||
| Allele (210) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes predicted protein of 4753 aa, extensive homology to mammalian LRP (4525 aa). [Yochem and Greenwald 1993; GS] | ||||||||
| Strain | WBStrain00002462 | ||||||||
| WBStrain00003528 | |||||||||
| WBStrain00024195 | |||||||||
| WBStrain00026497 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00003072 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00003738 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004374 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008609 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008779 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015083 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019756 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019811 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020481 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lrp-1 encodes a low-density lipoprotein (LDL) receptor-like protein most closely related to the vertebrate gp330/megalin/LRP-2 proteins; during development, lrp-1 activity is required in the hyp7 syncytium for completion of molting and for growth beyond the third larval stage; LRP-1 is expressed on the apical surface of the hyp6 and hyp7 syncytia in hermaphrodites and males from hatching through adulthood; as sterol starvation mimics the lrp-1 mutant phenotype, LRP-1 is likely to function as a receptor for sterols normally endocytosed by the hyp7 syncytium. | Paper_evidence | WBPaper00003399 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 12 Mar 2007 00:00:00 | ||||||||
| Automated_description | Enables sterol transporter activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; nematode larval development; and regulation of locomotion. Located in apical plasma membrane and endocytic vesicle. Expressed in head; hyp6; hyp7 syncytium; and hypodermal cell. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Is an ortholog of human LRP2 (LDL receptor related protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:7188 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6694) | ||||
| DOID:0090144 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6694) | ||||||
| Molecular_info | Corresponding_CDS | F29D11.1 | |||||||
| Corresponding_transcript | F29D11.1.1 | ||||||||
| Other_sequence (60) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (24) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00003059 | ||||||||
| WBCnstr00004528 | |||||||||
| WBCnstr00006430 | |||||||||
| WBCnstr00036250 | |||||||||
| Construct_product | WBCnstr00006430 | ||||||||
| WBCnstr00015769 | |||||||||
| WBCnstr00036250 | |||||||||
| Antibody | WBAntibody00000211 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (221) | |||||||||
| Interaction (49) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | I | Position | 2.21043 | Error | 0.000575 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F29D11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| GS#Y54 | |||||||||
| Mapping_data | Multi_point | 3910 | |||||||
| 4644 | |||||||||
| Reference (51) | |||||||||
| Method | Gene |
