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WormBase Tree Display for Gene: WBGene00003166

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Name Class

WBGene00003166SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namemec-2Person_evidenceWBPerson95
Sequence_nameF14D12.4
Molecular_name (51)
Other_nameCELE_F14D12.4Accession_evidenceNDBBX284606
Public_namemec-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmec
Allele (374)
Legacy_informationSee also e75, e1084, e1514
[C.elegansII] u8amb : touch insensitive; lethargic. ES2. ME?. OA>50: e75 (recessive, ME3), u7cs, e1084 (probable null), e1514, e1608dm, u284sd, etc. Alleles vary in phenotype from weak recessive to strong dominant Mec; complex complementation. Cloned: encodes predicted 440 aa protein with central similarity to human stomatin (65% identity over 247 aa). mec-2:lacZ expressed in cell bodies and processes of touch cells, some other neurons.??? [Chalfie and Au 1989; Huang et al. 1995; TU]
StrainWBStrain00002820
WBStrain00037747
WBStrain00004463
WBStrain00004092
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (36)
ParalogWBGene00006761Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006068Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006065Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006741Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006064Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006063Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006067Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006066Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006061Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionThe mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall.Paper_evidenceWBPaper00005127
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables cholesterol binding activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Located in neuron projection membrane. Expressed in sensory neurons. Used to study nephrotic syndrome. Is an ortholog of human STOM (stomatin).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1184Homo sapiensPaper_evidenceWBPaper00044961
Accession_evidenceOMIM600995
Curator_confirmedWBPerson324
Date_last_updated25 Sep 2018 00:00:00
Models_disease_in_annotationWBDOannot00000328
Molecular_infoCorresponding_CDS (17)
Corresponding_transcript (17)
Other_sequence (86)
Associated_feature (17)
Experimental_infoRNAi_resultWBRNAi00027647Inferred_automaticallyRNAi_primary
WBRNAi00013263Inferred_automaticallyRNAi_primary
WBRNAi00044585Inferred_automaticallyRNAi_primary
Expr_pattern (18)
Drives_constructWBCnstr00003347
WBCnstr00004794
WBCnstr00010333
WBCnstr00011303
WBCnstr00011304
WBCnstr00036204
WBCnstr00042668
WBCnstr00042669
Construct_productWBCnstr00010333
WBCnstr00011303
WBCnstr00036204
AntibodyWBAntibody00000792
WBAntibody00000793
WBAntibody00001354
WBAntibody00001686
WBAntibody00002696
Microarray_results (40)
Expression_cluster (164)
Interaction (81)
WBProcessWBbiopr:00000002
Map_infoMapXPosition-4.70552Error0.075755
Well_ordered
PositivePositive_cloneF14D12Inferred_automaticallyFrom sequence, transcript, pseudogene data
W05G12RemarkAlternative clone not in the golden path of clones.
NegativeOutside_rearrmcDf2
Mapping_dataMulti_point (11)
Pos_neg_data940
1832
3193
500
10696
ReferenceWBPaper00000214
WBPaper00000502
WBPaper00000608
WBPaper00001296
WBPaper00001364
WBPaper00001704
WBPaper00001786
WBPaper00001871
WBPaper00002333
WBPaper00002362
WBPaper00002465
WBPaper00002474
WBPaper00002482
WBPaper00002489
WBPaper00002579
WBPaper00002721
WBPaper00002737
WBPaper00002800
WBPaper00003300
WBPaper00003408
WBPaper00003582
WBPaper00003828
WBPaper00003833
WBPaper00003848
WBPaper00004243
WBPaper00004271
WBPaper00004360
WBPaper00004401
WBPaper00004649
WBPaper00005234
WBPaper00005591
WBPaper00005666
WBPaper00005787
WBPaper00005849
WBPaper00006076
WBPaper00010336
WBPaper00010529
WBPaper00010807
WBPaper00010869
WBPaper00010970
WBPaper00011058
WBPaper00011094
WBPaper00011186
WBPaper00011599
WBPaper00012655
WBPaper00015038
WBPaper00015423
WBPaper00015440
WBPaper00015515
WBPaper00016539
WBPaper00017779
WBPaper00018284
WBPaper00018346
WBPaper00018540
WBPaper00018904
WBPaper00019338
WBPaper00021836
WBPaper00022179
WBPaper00022318
WBPaper00022533
WBPaper00022939
WBPaper00023156
WBPaper00023961
WBPaper00023963
WBPaper00024027
WBPaper00024103
WBPaper00024447
WBPaper00024569
WBPaper00024641
WBPaper00024867
WBPaper00024889
WBPaper00026063
WBPaper00026898
WBPaper00026908
WBPaper00027029
WBPaper00027280
WBPaper00028488
WBPaper00028756
WBPaper00029013
WBPaper00029014
WBPaper00029017
WBPaper00030489
WBPaper00031345
WBPaper00031907
WBPaper00034222
WBPaper00036089
WBPaper00037308
WBPaper00038491
WBPaper00039217
WBPaper00040149
WBPaper00042045
WBPaper00042312
WBPaper00043186
WBPaper00043466
WBPaper00044004
WBPaper00044961
WBPaper00047789
WBPaper00047857
WBPaper00047874
WBPaper00048504
WBPaper00049330
WBPaper00049517
WBPaper00050351
WBPaper00051743
WBPaper00055090
WBPaper00061109
WBPaper00062197
WBPaper00063427
WBPaper00063577
WBPaper00063670
WBPaper00064546
WBPaper00065227
WBPaper00066107
RemarkUpdated positive clone to correspond to the sequenced clone instead of just W05G12
MethodGene