WormBase Tree Display for Gene: WBGene00003167
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| WBGene00003167 | SMap | S_parent | Sequence | F01D4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mec-3 | Person_evidence | WBPerson95 | |||||
| Sequence_name | F01D4.6 | ||||||||
| Molecular_name | F01D4.6a | ||||||||
| F01D4.6a.1 | |||||||||
| CE27422 | |||||||||
| F01D4.6c | |||||||||
| CE42646 | |||||||||
| F01D4.6d | |||||||||
| CE52302 | |||||||||
| F01D4.6c.1 | |||||||||
| F01D4.6d.1 | |||||||||
| Other_name | CELE_F01D4.6 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | mec-3 | ||||||||
| DB_info | Database | AceView | gene | 4L224 | |||||
| WormQTL | gene | WBGene00003167 | |||||||
| WormFlux | gene | WBGene00003167 | |||||||
| NDB | locus_tag | CELE_F01D4.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003167|UniProtKB=P09088 | |||||||
| family | PTHR24208 | ||||||||
| NCBI | gene | 177938 | |||||||
| RefSeq | protein | NM_001136380.4 | |||||||
| NM_001027940.5 | |||||||||
| NM_001356932.4 | |||||||||
| SwissProt | UniProtAcc | P09088 | |||||||
| TrEMBL | UniProtAcc | A0A2C9C378 | |||||||
| UniProt_GCRP | UniProtAcc | P09088 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mec | ||||||||
| Reference_allele | WBVar00143928 | ||||||||
| Allele (57) | |||||||||
| Legacy_information | e1338 : touch insensitive lethargic microtubule cells small and lacking processes ALM and PLM cells displaced. ES2 ME2. NA8 (e1498 e1612 etc.). | ||||||||
| Class 2 revertant allele e1498u124 : ALM and PLM processes abnormally long. | |||||||||
| See also e1338 | |||||||||
| [C.elegansII] e1338 : touch insensitive, lethargic; microtubule cells small and lacking processes, ALM and PLM cells displaced. ES2 ME2. OA>10: e1498, e1612, u467amb, etc. Also revertant allele e1498u124 (ALM and PLM processes abnormally long). Cloned: encodes LIM class homeoprotein,expressed in touch receptors, FLP, PVD;extensive molecular analysis. [Way and Chalfie 1989; Xue et al. 1993; JW; TU] | |||||||||
| Strain | WBStrain00026815 | ||||||||
| WBStrain00027146 | |||||||||
| WBStrain00037306 | |||||||||
| WBStrain00037744 | |||||||||
| WBStrain00004302 | |||||||||
| WBStrain00006370 | |||||||||
| WBStrain00007579 | |||||||||
| WBStrain00052610 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (31) | |||||||||
| Paralog | WBGene00000438 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00002987 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00002988 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00002989 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WBGene00003000 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006654 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006824 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015216 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017644 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022518 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mec-3 encodes a founding member of the LIM (Lin-11, Isl-1, Mec-3) homeodomain family of transcriptional regulators; during C. elegans development, MEC-3 activity is required for proper differentiation and maturation of the mechanosensory neurons; MEC-3 is expressed in the mechanosensory neurons, where initiation of expression is dependent upon the UNC-86 homeodomain protein and maintenance of expression is dependent upon MEC-3 itself and mec-17. | Paper_evidence | WBPaper00000502 | |||||
| WBPaper00001052 | |||||||||
| WBPaper00001237 | |||||||||
| WBPaper00001829 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Sep 2005 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including mechanosensory behavior; neuron projection organization; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Expressed in VA neuron; touch receptor neurons; ventral nerve cord; and vulva. Is an ortholog of human LHX1 (LIM homeobox 1) and LHX5 (LIM homeobox 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F01D4.6a | |||||||
| F01D4.6c | |||||||||
| F01D4.6d | |||||||||
| Corresponding_CDS_history | F01D4.6:wp49 | ||||||||
| F01D4.6b:wp243 | |||||||||
| Corresponding_transcript | F01D4.6a.1 | ||||||||
| F01D4.6c.1 | |||||||||
| F01D4.6d.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature (31) | |||||||||
| Gene_product_binds (12) | |||||||||
| Transcription_factor | WBTranscriptionFactor000297 | ||||||||
| WBTranscriptionFactor000756 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00115820 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00084972 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012719 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043722 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (57) | |||||||||
| Construct_product | WBCnstr00004796 | ||||||||
| WBCnstr00006742 | |||||||||
| WBCnstr00009233 | |||||||||
| WBCnstr00010886 | |||||||||
| WBCnstr00015361 | |||||||||
| WBCnstr00016864 | |||||||||
| WBCnstr00019329 | |||||||||
| WBCnstr00036203 | |||||||||
| Antibody | WBAntibody00001500 | ||||||||
| WBAntibody00001560 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (225) | |||||||||
| WBProcess | WBbiopr:00000002 | ||||||||
| Map_info | Map | IV | Position | 4.59786 | Error | 0.000702 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf2 | |||||||
| Positive_clone | F01D4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| TU#3 | |||||||||
| Mapping_data | 2_point | 112 | |||||||
| Multi_point (19) | |||||||||
| Pos_neg_data | 1650 | ||||||||
| 1651 | |||||||||
| 1652 | |||||||||
| 1653 | |||||||||
| 1654 | |||||||||
| 1655 | |||||||||
| 3869 | |||||||||
| Reference (256) | |||||||||
| Method | Gene |
