WormBase Tree Display for Gene: WBGene00003175
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| WBGene00003175 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mec-12 | Person_evidence | WBPerson95 | |||||
| Sequence_name | C44B11.3 | ||||||||
| Molecular_name | C44B11.3 | ||||||||
| C44B11.3.1 | |||||||||
| CE24843 | |||||||||
| Other_name | tba-3 | ||||||||
| Alpha-tubulin | Accession_evidence | EMBL | D21134 | ||||||
| CELE_C44B11.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | mec-12 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mec | ||||||||
| Reference_allele | WBVar00144145 | ||||||||
| Allele (180) | |||||||||
| Legacy_information | e1605 : touch insensitive lethargic. ES2 ME3. NA10 (e1607 (weaker allele) u94sd (u94/+ touch insensitive in head only) etc.). Weak alleles often lack synaptic branch of AVM; strong alleles have few microtubules in microbule cell processes. | ||||||||
| [C.elegansII] e1605 : touch insensitive lethargic. ES2 ME3. NA15: e1607 (weaker allele), u94sd (u94/+ touch insensitive in head only), u241sd, etc. Weak alleles often lack synaptic branch of AVM; strong alleles have few microtubules in microbule cell processes, no 15 protofilament microtubules. Cloned: encodes alpha tubulin (pka tba-3).mec-12:lacZ expressed in touch cells, some other neurons also. [Chalfie and Au 1989; NW; SQ; TU] | |||||||||
| Strain | WBStrain00001499 | ||||||||
| WBStrain00004467 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (45) | |||||||||
| Ortholog (75) | |||||||||
| Paralog (16) | |||||||||
| Structured_description | Concise_description | mec-12 encodes an alpha-tubulin; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contain the microfilament bundle, such as the ventral cord motorneurons; MEC-12 is acetylated in a manner that is dependent upon MEC-17 and W06B11.1, which encode paralogous alpha-tubulin acetyltransferases. | Paper_evidence | WBPaper00003414 | |||||
| WBPaper00005666 | |||||||||
| WBPaper00037127 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Sep 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including positive regulation of multicellular organismal process; response to mechanical stimulus; and thigmotaxis. Located in axon; microtubule; and neuronal cell body. Expressed in nerve ring; neurons; and in male. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; amyotrophic lateral sclerosis type 22; and lissencephaly 3. Is an ortholog of human TUBA3C (tubulin alpha 3c) and TUBA3D (tubulin alpha 3d). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11832 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20766) | ||||
| DOID:10126 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:24071) | ||||||
| DOID:0112232 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20766) | ||||||
| DOID:0050453 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20766) | ||||||
| DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20766) | ||||||
| DOID:0060355 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12407) | ||||||
| DOID:14250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20766) | ||||||
| Molecular_info | Corresponding_CDS | C44B11.3 | |||||||
| Corresponding_transcript | C44B11.3.1 | ||||||||
| Other_sequence (161) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00068743 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027703 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011904 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00117198 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006557 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00068805 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076212 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042413 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram511 | ||||||||
| Expr1269 | |||||||||
| Expr4856 | |||||||||
| Expr5493 | |||||||||
| Expr16375 | |||||||||
| Expr1022948 | |||||||||
| Expr1031506 | |||||||||
| Expr1146401 | |||||||||
| Expr2013489 | |||||||||
| Expr2031723 | |||||||||
| Drives_construct | WBCnstr00002356 | ||||||||
| WBCnstr00005976 | |||||||||
| WBCnstr00005978 | |||||||||
| WBCnstr00009413 | |||||||||
| WBCnstr00009414 | |||||||||
| WBCnstr00009415 | |||||||||
| WBCnstr00010183 | |||||||||
| WBCnstr00012284 | |||||||||
| WBCnstr00042980 | |||||||||
| Construct_product | WBCnstr00005975 | ||||||||
| WBCnstr00005976 | |||||||||
| WBCnstr00005978 | |||||||||
| WBCnstr00009413 | |||||||||
| WBCnstr00009414 | |||||||||
| WBCnstr00009415 | |||||||||
| WBCnstr00010183 | |||||||||
| Antibody | WBAntibody00001691 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (286) | |||||||||
| Interaction (315) | |||||||||
| Map_info | Map | III | Position | -7.49759 | Error | 0.038654 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C44B11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C56F12 | |||||||||
| Mapping_data | 2_point | 496 | |||||||
| 1607 | |||||||||
| 4698 | |||||||||
| Multi_point | 425 | ||||||||
| 857 | |||||||||
| 1579 | |||||||||
| 1626 | |||||||||
| 1627 | |||||||||
| 1879 | |||||||||
| 2039 | |||||||||
| 2439 | |||||||||
| 4017 | |||||||||
| Pos_neg_data | 6855 | ||||||||
| Landmark_gene | |||||||||
| Reference (87) | |||||||||
| Method | Gene |
