| WBGene00003222 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | Y2H9A |
| Identity | Version | 1 |
| | Name | CGC_name | mes-4 | Person_evidence | WBPerson632 |
| | | Sequence_name | Y2H9A.1 |
| | | Molecular_name | Y2H9A.1 |
| | | | Y2H9A.1.1 |
| | | | CE27781 |
| | | Other_name | CELE_Y2H9A.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | mes-4 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mes |
| | Allele (85) |
| | Legacy_information | [C.elegansII] bn50 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults(only 10 germ cells made). Normal P granule staining. XO germ line much less affected.OA3: bn23, bn58, bn67 (all similar). [Capowski et al. 1991; SS] |
| | Strain | WBStrain00022581 |
| | | WBStrain00034440 |
| | | WBStrain00036937 |
| | | WBStrain00029957 |
| | RNASeq_FPKM (74) |
| | GO_annotation (30) |
| | Ortholog | WBGene00052793 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00028946 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00145065 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00116884 | Pristionchus pacificus | From_analysis | Inparanoid_8 |
| | | WBGene00101279 | Pristionchus pacificus | From_analysis | Inparanoid_8 |
| | | WBGene00222977 | Brugia malayi | From_analysis | WormBase-Compara |
| | | WBGene00226014 | Brugia malayi | From_analysis | WormBase-Compara |
| | | WBGene00226798 | Brugia malayi | From_analysis | WormBase-Compara |
| | | WBGene00230701 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g1484 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CBOVI.g7534 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP21.g10825 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP21.g11380 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP21.g2416 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP26.g11669 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g11351 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g16822 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP29.g4972 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP31.g9302 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP38.g1989 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g17909 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP39.g3595 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP40.g7759 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_00298.g8741 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_01039.g15462 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_09566.g22143 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cni-mes-4 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold476.g1727 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00054.g2723 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00149.g5661 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | FL83_03825 | Caenorhabditis latens | From_analysis | WormBase-Compara |
| | | GCK72_018575 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g01801 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g11610 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_50158400 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrV_pilon.g16243 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00237385 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00238265 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00246807 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00291387 | Trichuris muris | From_analysis | WormBase-Compara |
| | | WBGene00296004 | Trichuris muris | From_analysis | WormBase-Compara |
| | | WBGene00302914 | Trichuris muris | From_analysis | WormBase-Compara |
| | | FB:FBgn0039559 | Drosophila melanogaster | From_analysis | OrthoInspector |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-080519-3 | Danio rerio | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-080519-2 | Danio rerio | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-030131-2581 | Danio rerio | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-050324-2 | Danio rerio | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | HGNC:12766 | Homo sapiens | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | HGNC:12767 | Homo sapiens | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | HGNC:14234 | Homo sapiens | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | MGI:1276545 | Mus musculus | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | MGI:1276574 | Mus musculus | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | MGI:2142581 | Mus musculus | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | RGD:1308980 | Rattus norvegicus | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | RGD:1307748 | Rattus norvegicus | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | | RGD:1307955 | Rattus norvegicus | From_analysis | PhylomeDB |
| | | | | | SonicParanoid |
| | Paralog (19) |
| | Structured_description | Concise_description | mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex. | Paper_evidence | WBPaper00002979 |
| | | | | | WBPaper00005301 |
| | | | | | WBPaper00005923 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 30 Jul 2004 00:00:00 |
| | | Automated_description | Enables histone H3K36 methyltransferase activity. Involved in germ-line sex determination and heterochromatin formation. Acts upstream of or within with a positive effect on dosage compensation by hypoactivation of X chromosome. Located in X chromosome; autosome; and nuclear chromosome. Part of chromatin. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 1; lung non-small cell carcinoma; and neuroblastoma. Is an ortholog of human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0112103 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12766) |
| | | DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:14748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:8692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12767) |
| | | DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| Molecular_info | Corresponding_CDS | Y2H9A.1 |
| | Corresponding_CDS_history | Y2H9A.1:wp51 |
| | Corresponding_transcript | Y2H9A.1.1 |
| | Other_sequence | AF233290 |
| | | CBC09012_1 |
| | | CBC03017_1 |
| | | CRC01044_1 |
| | | CR09817 |
| | | CR07209 |
| | | CRC02608_1 |
| | Associated_feature (11) |
| | Gene_product_binds (4418) |
| | Transcription_factor | WBTranscriptionFactor000137 |
| Experimental_info | RNAi_result (41) |
| | Expr_pattern | Expr1905 |
| | | Expr4222 |
| | | Expr14367 |
| | | Expr1027992 |
| | | Expr1031522 |
| | | Expr1159295 |
| | | Expr1200052 |
| | | Expr2013532 |
| | | Expr2031766 |
| | Drives_construct | WBCnstr00036178 |
| | Construct_product | WBCnstr00036178 |
| | Regulate_expr_cluster | WBPaper00028483:Down_mes-4_vs_WT |
| | | WBPaper00028483:Up_mes-4_vs_WT |
| | | WBPaper00041688:mes-2_mes-4_downregulated |
| | | WBPaper00041688:mes-2_mes-4_upregulated |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_downregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | Antibody | WBAntibody00000524 |
| | | WBAntibody00001161 |
| | | WBAntibody00001162 |
| | | WBAntibody00001462 |
| | Microarray_results (18) |
| | Expression_cluster (153) |
| | Interaction (83) |
| Map_info | Map | V | Position | 5.34414 | Error | 0.004146 |
| | Well_ordered |
| | Positive | Positive_clone | Y2H9A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | Y29H9A |
| | Mapping_data | 2_point | 6090 |
| | | | 6091 |
| | | | 6092 |
| | | | 6093 |
| | | | 6094 |
| | | | 6095 |
| | | | 6096 |
| | | | 6097 |
| | | | 6098 |
| | | Multi_point | 2157 |
| | | | 2158 |
| | | | 2159 |
| | | | 2160 |
| | | | 2161 |
| | | | 2162 |
| | | | 2163 |
| | | | 2164 |
| | | | 2165 |
| | | | 2166 |
| | | Pos_neg_data | 6685 |
| | | | 6686 |
| | | | 6687 |
| | Landmark_gene |
| Reference (120) |
| Remark | Sequence connection from [Strome S] |
| Method | Gene |
