WormBase Tree Display for Gene: WBGene00003222
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WBGene00003222 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y2H9A | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | mes-4 | Person_evidence | WBPerson632 | |||||
Sequence_name | Y2H9A.1 | ||||||||
Molecular_name | Y2H9A.1 | ||||||||
Y2H9A.1.1 | |||||||||
CE27781 | |||||||||
Other_name | CELE_Y2H9A.1 | Accession_evidence | NDB | BX284605 | |||||
Public_name | mes-4 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mes | ||||||||
Allele (85) | |||||||||
Legacy_information | [C.elegansII] bn50 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults(only 10 germ cells made). Normal P granule staining. XO germ line much less affected.OA3: bn23, bn58, bn67 (all similar). [Capowski et al. 1991; SS] | ||||||||
Strain | WBStrain00022581 | ||||||||
WBStrain00034440 | |||||||||
WBStrain00036937 | |||||||||
WBStrain00029957 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (30) | |||||||||
Ortholog (56) | |||||||||
Paralog (19) | |||||||||
Structured_description | Concise_description | mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex. | Paper_evidence | WBPaper00002979 | |||||
WBPaper00005301 | |||||||||
WBPaper00005923 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 30 Jul 2004 00:00:00 | ||||||||
Automated_description | Enables histone H3K36 methyltransferase activity. Involved in germ-line sex determination and heterochromatin formation. Acts upstream of or within with a positive effect on dosage compensation by hypoactivation of X chromosome. Located in X chromosome; autosome; and nuclear chromosome. Part of chromatin. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 1; lung non-small cell carcinoma; and neuroblastoma. Is an ortholog of human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0112103 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12766) | ||||||
DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
DOID:14748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
DOID:769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
DOID:8692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12767) | ||||||
DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
Molecular_info | Corresponding_CDS | Y2H9A.1 | |||||||
Corresponding_CDS_history | Y2H9A.1:wp51 | ||||||||
Corresponding_transcript | Y2H9A.1.1 | ||||||||
Other_sequence | AF233290 | ||||||||
CBC09012_1 | |||||||||
CBC03017_1 | |||||||||
CRC01044_1 | |||||||||
CR09817 | |||||||||
CR07209 | |||||||||
CRC02608_1 | |||||||||
Associated_feature (11) | |||||||||
Gene_product_binds (4418) | |||||||||
Transcription_factor | WBTranscriptionFactor000137 | ||||||||
Experimental_info | RNAi_result (41) | ||||||||
Expr_pattern | Expr1905 | ||||||||
Expr4222 | |||||||||
Expr14367 | |||||||||
Expr1027992 | |||||||||
Expr1031522 | |||||||||
Expr1159295 | |||||||||
Expr1200052 | |||||||||
Expr2013532 | |||||||||
Expr2031766 | |||||||||
Drives_construct | WBCnstr00036178 | ||||||||
Construct_product | WBCnstr00036178 | ||||||||
Regulate_expr_cluster | WBPaper00028483:Down_mes-4_vs_WT | ||||||||
WBPaper00028483:Up_mes-4_vs_WT | |||||||||
WBPaper00041688:mes-2_mes-4_downregulated | |||||||||
WBPaper00041688:mes-2_mes-4_upregulated | |||||||||
WBPaper00064315:mes-4(bn73)_downregulated_EGCs | |||||||||
WBPaper00064315:mes-4(bn73)_downregulated_PGCs | |||||||||
WBPaper00064315:mes-4(bn73)_upregulated_EGCs | |||||||||
WBPaper00064315:mes-4(bn73)_upregulated_PGCs | |||||||||
Antibody | WBAntibody00000524 | ||||||||
WBAntibody00001161 | |||||||||
WBAntibody00001162 | |||||||||
WBAntibody00001462 | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (153) | |||||||||
Interaction (83) | |||||||||
Map_info | Map | V | Position | 5.34414 | Error | 0.004146 | |||
Well_ordered | |||||||||
Positive | Positive_clone | Y2H9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Y29H9A | |||||||||
Mapping_data | 2_point | 6090 | |||||||
6091 | |||||||||
6092 | |||||||||
6093 | |||||||||
6094 | |||||||||
6095 | |||||||||
6096 | |||||||||
6097 | |||||||||
6098 | |||||||||
Multi_point | 2157 | ||||||||
2158 | |||||||||
2159 | |||||||||
2160 | |||||||||
2161 | |||||||||
2162 | |||||||||
2163 | |||||||||
2164 | |||||||||
2165 | |||||||||
2166 | |||||||||
Pos_neg_data | 6685 | ||||||||
6686 | |||||||||
6687 | |||||||||
Landmark_gene | |||||||||
Reference | WBPaper00001477 | ||||||||
WBPaper00001654 | |||||||||
WBPaper00001965 | |||||||||
WBPaper00002009 | |||||||||
WBPaper00002631 | |||||||||
WBPaper00002979 | |||||||||
WBPaper00003143 | |||||||||
WBPaper00003144 | |||||||||
WBPaper00003145 | |||||||||
WBPaper00003633 | |||||||||
WBPaper00003711 | |||||||||
WBPaper00003990 | |||||||||
WBPaper00004507 | |||||||||
WBPaper00004549 | |||||||||
WBPaper00004657 | |||||||||
WBPaper00005020 | |||||||||
WBPaper00005193 | |||||||||
WBPaper00005301 | |||||||||
WBPaper00005352 | |||||||||
WBPaper00005498 | |||||||||
WBPaper00005605 | |||||||||
WBPaper00005923 | |||||||||
WBPaper00006157 | |||||||||
WBPaper00006223 | |||||||||
WBPaper00006404 | |||||||||
WBPaper00006478 | |||||||||
WBPaper00010271 | |||||||||
WBPaper00010541 | |||||||||
WBPaper00011269 | |||||||||
WBPaper00012598 | |||||||||
WBPaper00014214 | |||||||||
WBPaper00015013 | |||||||||
WBPaper00015148 | |||||||||
WBPaper00018328 | |||||||||
WBPaper00018730 | |||||||||
WBPaper00018889 | |||||||||
WBPaper00020766 | |||||||||
WBPaper00022139 | |||||||||
WBPaper00022371 | |||||||||
WBPaper00023117 | |||||||||
WBPaper00023809 | |||||||||
WBPaper00025139 | |||||||||
WBPaper00025586 | |||||||||
WBPaper00025593 | |||||||||
WBPaper00026301 | |||||||||
WBPaper00026473 | |||||||||
WBPaper00026592 | |||||||||
WBPaper00026593 | |||||||||
WBPaper00026665 | |||||||||
WBPaper00026963 | |||||||||
WBPaper00027128 | |||||||||
WBPaper00027135 | |||||||||
WBPaper00027259 | |||||||||
WBPaper00027298 | |||||||||
WBPaper00027634 | |||||||||
WBPaper00028483 | |||||||||
WBPaper00028983 | |||||||||
WBPaper00028985 | |||||||||
WBPaper00030771 | |||||||||
WBPaper00030864 | |||||||||
WBPaper00032169 | |||||||||
WBPaper00032180 | |||||||||
WBPaper00032309 | |||||||||
WBPaper00033449 | |||||||||
WBPaper00035245 | |||||||||
WBPaper00036383 | |||||||||
WBPaper00036534 | |||||||||
WBPaper00036995 | |||||||||
WBPaper00037058 | |||||||||
WBPaper00037131 | |||||||||
WBPaper00038168 | |||||||||
WBPaper00038372 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00038696 | |||||||||
WBPaper00038699 | |||||||||
WBPaper00039542 | |||||||||
WBPaper00039580 | |||||||||
WBPaper00039717 | |||||||||
WBPaper00039770 | |||||||||
WBPaper00040874 | |||||||||
WBPaper00041023 | |||||||||
WBPaper00041688 | |||||||||
WBPaper00041751 | |||||||||
WBPaper00041967 | |||||||||
WBPaper00042674 | |||||||||
WBPaper00042939 | |||||||||
WBPaper00043989 | |||||||||
WBPaper00044000 | |||||||||
WBPaper00044545 | |||||||||
WBPaper00045091 | |||||||||
WBPaper00046889 | |||||||||
WBPaper00047313 | |||||||||
WBPaper00048029 | |||||||||
WBPaper00048207 | |||||||||
WBPaper00048348 | |||||||||
WBPaper00048776 | |||||||||
WBPaper00050362 | |||||||||
WBPaper00050374 | |||||||||
WBPaper00050959 | |||||||||
WBPaper00051900 | |||||||||
WBPaper00052019 | |||||||||
WBPaper00052321 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00055275 | |||||||||
WBPaper00056499 | |||||||||
WBPaper00056680 | |||||||||
WBPaper00057713 | |||||||||
WBPaper00057850 | |||||||||
WBPaper00058052 | |||||||||
WBPaper00060493 | |||||||||
WBPaper00060886 | |||||||||
WBPaper00061791 | |||||||||
WBPaper00061919 | |||||||||
WBPaper00062457 | |||||||||
WBPaper00062587 | |||||||||
WBPaper00062786 | |||||||||
WBPaper00063185 | |||||||||
WBPaper00064315 | |||||||||
WBPaper00064973 | |||||||||
WBPaper00065308 | |||||||||
Remark | Sequence connection from [Strome S] | ||||||||
Method | Gene |