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WormBase Tree Display for Gene: WBGene00003230

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Name Class

WBGene00003230EvidenceCGC_data_submission
SMapS_parentSequenceW02A2
IdentityVersion1
NameCGC_namemex-5Person_evidenceWBPerson498
Sequence_nameW02A2.7
Molecular_nameW02A2.7
W02A2.7.1
CE21237
Other_nameCELE_W02A2.7Accession_evidenceNDBBX284604
Public_namemex-5
DB_infoDatabaseAceViewgene4O119
WormQTLgeneWBGene00003230
WormFluxgeneWBGene00003230
NDBlocus_tagCELE_W02A2.7
PanthergeneCAEEL|WormBase=WBGene00003230|UniProtKB=Q9XUB2
familyPTHR12547
NCBIgene178296
RefSeqproteinNM_070165.7
SwissProtUniProtAccQ9XUB2
TREEFAMTREEFAM_IDTF322043
UniProt_GCRPUniProtAccQ9XUB2
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmex
Allele (51)
Legacy_information[Priess, J.] zu199: maternal-effect lethal mutation. Embryos produce excess intestine and pharyngeal muscle from the AB blastomere, while germ cells appear normal in most embryos by morphological criteria.
Strain (15)
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (30)
Paralog (20)
Structured_descriptionConcise_descriptionmex-5 encodes a novel protein that contains two CCCH zinc finger motifs; maternally provided MEX-5, which functions partly redundantly with the highly similar CCCH finger protein MEX-6, is essential for transducing polarity cues and establishing soma/germline asymmetry in the early embryo; in regulating soma/germline asymmetry, MEX-5 interacts with, and activates, the SOCS-box protein ZIF-1, which functions as part of an E3 ubiquitin ligase complex that degrades germ plasm proteins in somatic blastomeres; accordingly, ectopic expression of MEX-5 throughout the early embryo results in reduced expression of germline proteins in germline blastomeres; MEX-5 activity is regulated in vivo by PLK-1 and PLK-2, which presumably bind and phosphorylate MBK-2-primed MEX-5; MEX-5 is a cytoplasmic protein expressed at uniform levels in oocytes and newly fertilized eggs; from the 1-cell to 4-cell stages of embryogenesis, MEX-5 expression is dynamic, with highest levels seen in the anterior AB blastomere and, for a time, its daughters, the anterior portion of the P1 blastomere, P1 centrosomes (both, then posterior only), and the EMS and C blastomeres; the asymmetric distribution of MEX-5 in early embryos depends upon a phosphorylation/dephosphorylation cycle by the PAR-1 kinase and PP2A phosphatases including LET-92, that regulate MEX-5's association with slow- or fast-diffusing RNA-containing complexes.Paper_evidenceWBPaper00004112
WBPaper00005160
WBPaper00005735
WBPaper00005930
WBPaper00006004
WBPaper00031434
WBPaper00040201
Curator_confirmedWBPerson1843
Date_last_updated03 Oct 2011 00:00:00
Automated_descriptionEnables RNA binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule and centrosome. Expressed in germ line; head muscle; head neurons; intestine; and somatic nervous system.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSW02A2.7
Corresponding_transcriptW02A2.7.1
Other_sequence (40)
Associated_featureWBsf977016
WBsf977017
WBsf977018
WBsf977019
WBsf977020
WBsf977021
WBsf977022
WBsf978625
WBsf229424
WBsf229425
Gene_product_bindsWBsf034344
WBsf034345
WBsf034346
WBsf034347
WBsf034348
WBsf034349
WBsf034350
WBsf034351
WBsf034352
Transcription_factorWBTranscriptionFactor000124
Experimental_infoRNAi_result (42)
Expr_patternExpr2463
Expr4082
Expr7693
Expr1027384
Expr1031527
Expr1158094
Expr2013543
Expr2031777
Drives_constructWBCnstr00005289
WBCnstr00008772
WBCnstr00008773
WBCnstr00008775
WBCnstr00009041
WBCnstr00009042
WBCnstr00009043
WBCnstr00009044
WBCnstr00009045
WBCnstr00009046
WBCnstr00009047
WBCnstr00009055
WBCnstr00009056
WBCnstr00009113
WBCnstr00009318
WBCnstr00009319
WBCnstr00009320
WBCnstr00009321
WBCnstr00009322
WBCnstr00009323
WBCnstr00009324
WBCnstr00009325
WBCnstr00009441
WBCnstr00009554
WBCnstr00009940
WBCnstr00012838
WBCnstr00014627
WBCnstr00014628
WBCnstr00014630
WBCnstr00014631
WBCnstr00014707
WBCnstr00014709
WBCnstr00014710
WBCnstr00014711
WBCnstr00014712
WBCnstr00014713
WBCnstr00014714
WBCnstr00014715
WBCnstr00014716
WBCnstr00014717
WBCnstr00014834
WBCnstr00014906
WBCnstr00015417
WBCnstr00015418
WBCnstr00015419
WBCnstr00015420
WBCnstr00015421
WBCnstr00017287
WBCnstr00017389
WBCnstr00017411
WBCnstr00018079
WBCnstr00018080
WBCnstr00018081
WBCnstr00018082
WBCnstr00018083
WBCnstr00018084
WBCnstr00018085
WBCnstr00018086
WBCnstr00018087
WBCnstr00018088
WBCnstr00018089
WBCnstr00018090
WBCnstr00018093
WBCnstr00018094
WBCnstr00018095
WBCnstr00018100
WBCnstr00018101
WBCnstr00018102
WBCnstr00018103
WBCnstr00018104
WBCnstr00018105
WBCnstr00018494
WBCnstr00018954
WBCnstr00018955
WBCnstr00018956
WBCnstr00019694
WBCnstr00019695
WBCnstr00019776
WBCnstr00019777
WBCnstr00019778
WBCnstr00019857
WBCnstr00019926
WBCnstr00019984
WBCnstr00020029
WBCnstr00020030
WBCnstr00020031
WBCnstr00020033
WBCnstr00020311
WBCnstr00020424
WBCnstr00020441
WBCnstr00020442
WBCnstr00020443
WBCnstr00020444
WBCnstr00020445
WBCnstr00020548
WBCnstr00020621
WBCnstr00020894
WBCnstr00020917
WBCnstr00020926
WBCnstr00020928
WBCnstr00020941
WBCnstr00021275
WBCnstr00021276
WBCnstr00021277
WBCnstr00021278
WBCnstr00021279
WBCnstr00021280
WBCnstr00021287
WBCnstr00021610
WBCnstr00022255
WBCnstr00022258
WBCnstr00023074
WBCnstr00023075
WBCnstr00023076
WBCnstr00023077
WBCnstr00023078
WBCnstr00023079
WBCnstr00023080
WBCnstr00023081
WBCnstr00023082
WBCnstr00023083
WBCnstr00023084
WBCnstr00023167
WBCnstr00036174
WBCnstr00038146
WBCnstr00038147
WBCnstr00038148
WBCnstr00038149
WBCnstr00038756
WBCnstr00038757
WBCnstr00038758
WBCnstr00038982
WBCnstr00038983
WBCnstr00038984
WBCnstr00039106
WBCnstr00039107
WBCnstr00039241
WBCnstr00039303
WBCnstr00039581
WBCnstr00039667
WBCnstr00039782
WBCnstr00039798
WBCnstr00039799
WBCnstr00039802
WBCnstr00039979
WBCnstr00039982
WBCnstr00040132
WBCnstr00040199
WBCnstr00040200
WBCnstr00041136
WBCnstr00041137
WBCnstr00041138
WBCnstr00041144
WBCnstr00041740
WBCnstr00041962
WBCnstr00041963
WBCnstr00041964
WBCnstr00041969
WBCnstr00042005
WBCnstr00042395
WBCnstr00042543
WBCnstr00042787
WBCnstr00042789
WBCnstr00043000
WBCnstr00043029
Construct_product (27)
AntibodyWBAntibody00000279
WBAntibody00000903
WBAntibody00001692
WBAntibody00002283
WBAntibody00002284
WBAntibody00002285
Microarray_results (22)
Expression_cluster (219)
Interaction (311)
WBProcessWBbiopr:00000017
Map_infoMapIVPosition8.5394Error0.011779
Well_ordered
PositivePositive_cloneW02A2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point3912
3913
4914
Reference (109)
MethodGene