WormBase Tree Display for Gene: WBGene00003239
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| WBGene00003239 | SMap | S_parent | Sequence | C35C5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mig-2 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C35C5.4 | ||||||||
| Molecular_name | C35C5.4a | ||||||||
| C35C5.4a.1 | |||||||||
| CE18544 | |||||||||
| C35C5.4b | |||||||||
| CE50721 | |||||||||
| C35C5.4b.1 | |||||||||
| Other_name | CELE_C35C5.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mig-2 | ||||||||
| DB_info | Database | AceView | gene | XM167 | |||||
| WormQTL | gene | WBGene00003239 | |||||||
| WormFlux | gene | WBGene00003239 | |||||||
| NDB | locus_tag | CELE_C35C5.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003239|UniProtKB=G5EBV3 | |||||||
| family | PTHR24072 | ||||||||
| NCBI | gene | 181344 | |||||||
| RefSeq | protein | NM_077530.5 | |||||||
| NM_001313405.4 | |||||||||
| TrEMBL | UniProtAcc | A0A0K3AYI6 | |||||||
| G5EBV3 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EBV3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mig | ||||||||
| Allele (39) | |||||||||
| Legacy_information | rh17 : variable abnormal migration of Q neuroblasts HSN cells CAN cells. | ||||||||
| [C.elegansII] rh17 : variable abnormal migration of Q neuroblasts, HSN cells, CAN cells etc.; Egl; uncoordinated; axon defects. OA1. [Hedgecock et al. 1987; Desai et al. 1988; NJ] | |||||||||
| [Zipkin ID, Kindt RM, Kenyon CJ] mu28 homozygotes exhibit abnormal migration of Q daughters. Predicted gene C35C5.4, encodes Rho-related protein. | |||||||||
| Strain | WBStrain00024138 | ||||||||
| WBStrain00024141 | |||||||||
| WBStrain00024146 | |||||||||
| WBStrain00024159 | |||||||||
| WBStrain00024170 | |||||||||
| WBStrain00024172 | |||||||||
| WBStrain00028737 | |||||||||
| WBStrain00028748 | |||||||||
| WBStrain00032460 | |||||||||
| WBStrain00004808 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (56) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004357 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004287 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012532 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mig-2 encodes a member of the RhoG family of GTP-binding proteins; MIG-2 activity is required for migration of Q neuroblasts, HSN neurons, and CAN cells as well as neurite outgrowth and guidance; in regulating Q neuroblast migration and dendrite outgrowth, MIG-2 functions upstream of the ANI-1 anillin to asymmetrically regulate ANI-1 localization, and thus stabilize F-actin, at the leading edge and growth cone; MIG-2 is expressed in early embryos and in adults in the vulva, gonadal distal tip cells, and the sex myoblasts and their descendants. | Paper_evidence | WBPaper00046615 | |||||
| WBPaper00002878 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 28 May 2015 00:00:00 | ||||||||
| Automated_description | Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Expressed in several structures, including CAN; HSN; distal tip cell; touch receptor neurons; and vulval cell. Used to study epilepsy. Is an ortholog of human RHOG (ras homolog family member G). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000557 | ||||||||
| Molecular_info | Corresponding_CDS | C35C5.4a | |||||||
| C35C5.4b | |||||||||
| Corresponding_transcript | C35C5.4a.1 | ||||||||
| C35C5.4b.1 | |||||||||
| Other_sequence (25) | |||||||||
| Associated_feature | WBsf663364 | ||||||||
| WBsf1007033 | |||||||||
| WBsf1007034 | |||||||||
| WBsf1007035 | |||||||||
| WBsf236390 | |||||||||
| WBsf236391 | |||||||||
| WBsf236392 | |||||||||
| WBsf236393 | |||||||||
| WBsf236394 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern | Expr1463 | ||||||||
| Expr8941 | |||||||||
| Expr12554 | |||||||||
| Expr16070 | |||||||||
| Expr1019676 | |||||||||
| Expr1031535 | |||||||||
| Expr1145980 | |||||||||
| Expr2013570 | |||||||||
| Expr2031803 | |||||||||
| Drives_construct | WBCnstr00000269 | ||||||||
| WBCnstr00001031 | |||||||||
| WBCnstr00001032 | |||||||||
| WBCnstr00036166 | |||||||||
| Construct_product | WBCnstr00001031 | ||||||||
| WBCnstr00007681 | |||||||||
| WBCnstr00007697 | |||||||||
| WBCnstr00009004 | |||||||||
| WBCnstr00017999 | |||||||||
| WBCnstr00036166 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (122) | |||||||||
| Interaction (285) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| WBbiopr:00000015 | |||||||||
| WBbiopr:00000107 | |||||||||
| WBbiopr:00000111 | |||||||||
| Map_info | Map | X | Position | 4.35742 | Error | 0.06415 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C35C5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3673 | |||||||
| Reference (178) | |||||||||
| Remark | Data extracted from Zipkin et al. (1997) | ||||||||
| Method | Gene |
