WormBase Tree Display for Gene: WBGene00003247
expand all nodes | collapse all nodes | view schema
WBGene00003247 | SMap | S_parent | Sequence | ZC504 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | mig | ||||||
Allele (101) | |||||||
Legacy_information | [Hedgecock EM] QL migration resembles QR. Pleiotropic defects in hypodermis. | ||||||
[C.elegansII] rh148 : QL migration resembles QR. Pleiotropic defects in hypodermis. [CF] | |||||||
Strain | WBStrain00024147 | ||||||
WBStrain00024148 | |||||||
WBStrain00028841 | |||||||
WBStrain00028845 | |||||||
WBStrain00028859 | |||||||
WBStrain00004868 | |||||||
WBStrain00004869 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (29) | |||||||
Ortholog (41) | |||||||
Paralog (27) | |||||||
Structured_description | Concise_description | mig-15 encodes the C. elegans ortholog of vertebrate Nck-interacting kinase (NIK) which belongs to the STE20/germinal center kinase (GCK) family; MIG-15 is required for normal axon pathfinding, and to inhibit premature branching of commissures; RNAi of mig-15 and pat-3, which encodes a beta1A integrins, results in similar axonal defects, and mutations in ina-1, which encodes an alpha integrin chain, enhances the commissural phenotype of mig-15 mutations; MIG-15 also regulates multiple aspects Q cell behavior, including initial Q cell polarization (direction of lamellipodium extension) and maintenance of that polarity, as well as migration of the Q cells and their descendants; genetic mosaic analyses indicate that MIG-15 likely acts cell autonomously at least in AQR and PQR to regulate their migration; MIG-15 physically interacts with the cytoplasmic domain of the beta1A integrin, PAT-3; loss of mig-15 results in increased synapse number and synaptic tiling defect in DA neurons. | Paper_evidence | WBPaper00005218 | |||
WBPaper00032247 | |||||||
WBPaper00026842 | |||||||
WBPaper00006110 | |||||||
WBPaper00054962 | |||||||
Person_evidence | WBPerson3718 | ||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
WBPerson567 | |||||||
Date_last_updated | 10 Oct 2018 00:00:00 | ||||||
Automated_description | Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||
Curator_confirmed | WBPerson38202 | ||||||
Date_last_updated | 04 Jun 2018 00:00:00 | ||||||
Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | |||
DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||
DOID:0081216 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30765) | ||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||
DOID:2043 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||
Models_disease_asserted | WBDOannot00000550 | ||||||
WBDOannot00000551 | |||||||
WBDOannot00000555 | |||||||
Molecular_info | Corresponding_CDS | ZC504.4a | |||||
ZC504.4b | |||||||
ZC504.4c | |||||||
ZC504.4d | |||||||
Corresponding_transcript | ZC504.4a.1 | ||||||
ZC504.4b.1 | |||||||
ZC504.4c.1 | |||||||
ZC504.4d.1 | |||||||
Other_sequence (61) | |||||||
Associated_feature (18) | |||||||
Experimental_info | RNAi_result (21) | ||||||
Expr_pattern | Expr1844 | ||||||
Expr8961 | |||||||
Expr1027934 | |||||||
Expr1031541 | |||||||
Expr1162414 | |||||||
Expr2013563 | |||||||
Expr2031796 | |||||||
Drives_construct | WBCnstr00010481 | ||||||
WBCnstr00013639 | |||||||
WBCnstr00036163 | |||||||
Construct_product | WBCnstr00010481 | ||||||
WBCnstr00022525 | |||||||
WBCnstr00036163 | |||||||
Microarray_results (43) | |||||||
Expression_cluster (104) | |||||||
Interaction (111) | |||||||
Anatomy_function | WBbtf0783 | ||||||
WBbtf0784 | |||||||
WBProcess | WBbiopr:00000082 | ||||||
WBbiopr:00000107 | |||||||
WBbiopr:00000111 | |||||||
Map_info | Map | X | Position | 2.19018 | Error | 0.003698 | |
Well_ordered | |||||||
Positive | Positive_clone | ZC504 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 3293 | |||||
3294 | |||||||
3295 | |||||||
3296 | |||||||
4886 | |||||||
4133 | |||||||
Reference (46) | |||||||
Method | Gene |