WormBase Tree Display for Gene: WBGene00003258
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| WBGene00003258 | SMap | S_parent | Sequence | Y54E10A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | cogc-1 | Paper_evidence | WBPaper00026979 | |||||
| Person_evidence | WBPerson449 | ||||||||
| Sequence_name | Y54E10A.2 | ||||||||
| Molecular_name | Y54E10A.2 | ||||||||
| Y54E10A.2.1 | |||||||||
| CE39656 | |||||||||
| Other_name | mig-30 | Person_evidence | WBPerson261 | ||||||
| let-576 | Person_evidence | WBPerson533 | |||||||
| Y54E10a.m | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y54E10A.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | cogc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 16 Jan 2006 15:57:29 | WBPerson2970 | Event | Acquires_merge | WBGene00021825 | ||||
| Name_change | CGC_name | cogc-1 | |||||||
| Other_name | mig-30 | ||||||||
| 3 | 18 Jan 2006 10:02:34 | WBPerson1849 | Event | Acquires_merge | WBGene00021824 | ||||
| 4 | 05 Mar 2015 12:02:13 | WBPerson2970 | Event | Merged_into | WBGene00002755 | ||||
| Name_change | Other_name | let-576 | |||||||
| Acquires_merge | WBGene00002755 | ||||||||
| WBGene00021824 | |||||||||
| WBGene00021825 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cogc | ||||||||
| Allele (497) | |||||||||
| Legacy_information | [C.elegansII] h816 : early larval lethal. OA1: h494. [KR] | ||||||||
| Strain | WBStrain00023886 | ||||||||
| WBStrain00028703 | |||||||||
| WBStrain00036789 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Contained_in_operon | CEOP1090 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | cogc-1 encodes an ortholog of mammalian COG-1/ldlBp (OMIM:606973,mutated in congenital disorder of glycosylation type II), a subunit oflobe A of the conserved oligomeric Golgi complex (COGC); COGC-1 isrequired for normal gonadal distal tip cell migration, a process thatalso requires COGC-3 and six other orthologs of COGC subunits; COGC-1 isalso required for normal vulval morphology, growth rate, ventral nervecord fasciculation, and adult locomotion; COGC-1 has a predictedcoiled-coil N-terminal domain; COGC-1 co-precipitates with COGC-3, andthe amount of COGC-1 is lowered in a cogc-3 mutant, implying that theseproteins not only bind one another but stabilize one another in vivo; incogc-1 mutants, MIG-23 is abnormally localized and expressed withincells; in cogc-1 mutants, MIG-23's substrate MIG-17 is underglycosylatedand fails to bind to the gonadal basement membrane, but is stillsecreted normally from muscle cells; cogc-1, cogc-3, and mig-17 nullmutants do not enhance one another, indicating a shared genetic pathway;like other lobe A subunits in both C. elegans and S. cerevisiae, COGC-1is strongly required for normal function, while lobe B subunits are onlypartially required in either worms or yeast. | Paper_evidence | WBPaper00026979 | |||||
| WBPaper00028363 | |||||||||
| WBPaper00028599 | |||||||||
| WBPaper00028603 | |||||||||
| WBPaper00028604 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 25 Oct 2006 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including gonad morphogenesis; regulation of cell migration; and vulval development. Predicted to be located in Golgi apparatus. Predicted to be part of Golgi transport complex. Expressed in germ line. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Is an ortholog of human COG1 (component of oligomeric golgi complex 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070259 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6545) | ||||
| Molecular_info | Corresponding_CDS | Y54E10A.2 | |||||||
| Corresponding_transcript | Y54E10A.2.1 | ||||||||
| Other_sequence (18) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr4083 | ||||||||
| Expr1022794 | |||||||||
| Expr1031545 | |||||||||
| Expr1160783 | |||||||||
| Expr2010290 | |||||||||
| Expr2028532 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (100) | |||||||||
| SAGE_tag (11) | |||||||||
| Interaction | WBInteraction000028473 | ||||||||
| WBInteraction000202585 | |||||||||
| WBInteraction000512842 | |||||||||
| WBInteraction000517682 | |||||||||
| WBInteraction000540427 | |||||||||
| WBInteraction000548088 | |||||||||
| WBInteraction000551349 | |||||||||
| WBInteraction000575344 | |||||||||
| Map_info | Map | I | Position | -4.44835 | Error | 0.023785 | |||
| Hide_under | WBGene00002740 | ||||||||
| Positive | Positive_clone | Y54E10A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Outside_rearr | hDf24 | |||||||
| Mapping_data | Multi_point | 4063 | |||||||
| 5443 | |||||||||
| 5474 | |||||||||
| 5476 | |||||||||
| 5477 | |||||||||
| 5478 | |||||||||
| 5479 | |||||||||
| 5480 | |||||||||
| 5481 | |||||||||
| Reference | WBPaper00003985 | ||||||||
| WBPaper00014623 | |||||||||
| WBPaper00026979 | |||||||||
| WBPaper00028363 | |||||||||
| WBPaper00031095 | |||||||||
| WBPaper00036735 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040589 | |||||||||
| WBPaper00055090 | |||||||||
| Method | Gene |
