WormBase Tree Display for Gene: WBGene00003305

WBGene00003305 Evidence: Paper_evidence: WBPaper00004928
  SMap: S_parent: Sequence: T21B4
  Identity: Version: 1
    Name: CGC_name: mir-77 Person_evidence: WBPerson18
      Sequence_name: T21B4.13
      Molecular_name: T21B4.13
        T21B4.13a
        T21B4.13b
      Other_name: cel-mir-77 Remark: miRBase V21 import
            MirGeneDB 2.1 import
        CELE_T21B4.13 Accession_evidence: NDB BX284602
      Public_name: mir-77
    DB_info: Database: miRBase acc MI0000048
        SignaLink mirna cel-mir-77
        MirGeneDB cel Cel-Mir-77
        NDB locus_tag CELE_T21B4.13
        NCBI gene 260151
        RefSeq protein NR_000920.2
        RNAcentral URSid URS00002934DE
            URS000031E740
            URS00004F5F8D
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001265
    Gene_class: mir
    Allele (11)
    Strain: WBStrain00027548
    In_cluster: MIR-77
    RNASeq_FPKM (74)
    Structured_description: Concise_description: mir-77 encodes a microRNA (miRNA), a small noncoding RNA that is likely involved in post-transcriptional regulation of gene expression; miR-77 is expressed at high levels in L4 larvae, adults, and glp-4 mutant hermaphrodites lacking a germline, at low levels in L2 and L3 larvae, and is undetectable in L1 larvae and embryos; miR-77 is also detected in him-8 mutants and dauer larvae; miR-77 has an apparent ortholog in the nematode C. briggsae; the targets of miR-77 are not yet known. Paper_evidence: WBPaper00004927
            WBPaper00005825
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Is affected by several genes including eat-2; prg-1; and alg-1 based on RNA-seq studies. Is affected by multi-walled carbon nanotube based on RNA-seq studies. Used to study Parkinson's disease. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14330 Homo sapiens Paper_evidence: WBPaper00035654
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jan 2014 00:00:00
    Disease_relevance: mir-77 is a small non-protein coding RNA; microRNA expression profiling studies in an elegans transgenic model of Parkinson''s disease, where A53T alpha-synuclein is overexpressed, indicate that elegans mir-77 is differentially expressed. Homo sapiens Paper_evidence: WBPaper00035654
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jan 2014 00:00:00
  Models_disease_in_annotation: WBDOannot00000260
  Molecular_info: Corresponding_transcript: T21B4.13
      T21B4.13a
      T21B4.13b
    Other_sequence: AJ487600
    Associated_feature: WBsf979098
      WBsf990127
  Experimental_info: Expr_pattern: Expr2520
      Expr8470
      Expr10886
    Drives_construct: WBCnstr00013309
    Expression_cluster (34)
    Interaction: WBInteraction000541265
      WBInteraction000542494
  Map_info: Map: II Position: 10.2026 Error: 0.002716
    Positive: Positive_clone: T21B4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00004927
    WBPaper00005825
    WBPaper00031335
    WBPaper00032187
    WBPaper00035168
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene