WormBase Tree Display for Gene: WBGene00003368
expand all nodes | collapse all nodes | view schema
| WBGene00003368 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mkk-4 | Person_evidence | WBPerson250 | |||||
| Sequence_name | F42G10.2 | ||||||||
| Molecular_name | F42G10.2 | ||||||||
| F42G10.2.1 | |||||||||
| CE10328 | |||||||||
| Other_name | CELE_F42G10.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mkk-4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mkk | ||||||||
| Allele (36) | |||||||||
| Strain | WBStrain00002018 | ||||||||
| WBStrain00002475 | |||||||||
| WBStrain00036316 | |||||||||
| WBStrain00005394 | |||||||||
| WBStrain00040648 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (39) | |||||||||
| Paralog (25) | |||||||||
| Structured_description | Concise_description | mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles. | Paper_evidence | WBPaper00024955 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Oct 2006 00:00:00 | ||||||||
| Automated_description | Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in axon regeneration; p38MAPK cascade; and regulation of developmental growth. Located in cytoplasm. Expressed in head; neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K4 (mitogen-activated protein kinase kinase 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (14) | ||||||||
| Modifies_disease | DOID:10652 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00000728 | ||||||||
| Molecular_info | Corresponding_CDS | F42G10.2 | |||||||
| Corresponding_transcript | F42G10.2.1 | ||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf663216 | ||||||||
| WBsf716629 | |||||||||
| WBsf1006591 | |||||||||
| WBsf1023651 | |||||||||
| WBsf236233 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram1320 | ||||||||
| Expr1744 | |||||||||
| Expr6046 | |||||||||
| Expr8636 | |||||||||
| Expr1015804 | |||||||||
| Expr1031547 | |||||||||
| Expr1150977 | |||||||||
| Expr2013581 | |||||||||
| Expr2031814 | |||||||||
| Drives_construct | WBCnstr00002801 | ||||||||
| WBCnstr00004423 | |||||||||
| WBCnstr00010426 | |||||||||
| WBCnstr00013412 | |||||||||
| WBCnstr00014537 | |||||||||
| WBCnstr00014538 | |||||||||
| WBCnstr00036157 | |||||||||
| Construct_product | WBCnstr00013412 | ||||||||
| WBCnstr00014537 | |||||||||
| WBCnstr00014538 | |||||||||
| WBCnstr00036157 | |||||||||
| WBCnstr00042646 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (134) | |||||||||
| Interaction (82) | |||||||||
| WBProcess | WBbiopr:00000117 | ||||||||
| Map_info | Map | X | Position | 1.73426 | Error | 0.00029 | |||
| Positive | Positive_clone | F42G10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5561 | |||||||
| 4314 | |||||||||
| 4879 | |||||||||
| Reference (48) | |||||||||
| Remark | Sequence connection from [Villanueva A, Hengartner MO]. krb 13/11/01 | ||||||||
| Method | Gene |
