WormBase Tree Display for Gene: WBGene00003377

WBGene00003377 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C39E6
  Identity: Version: 1
    Name: CGC_name: mls-2 Person_evidence: WBPerson959
      Sequence_name: C39E6.4
      Molecular_name: C39E6.4
        C39E6.4.1
        CE30891
      Other_name: CELE_C39E6.4 Accession_evidence: NDB BX284606
      Public_name: mls-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mls
    Allele (64)
    Possibly_affected_by: WBVar02157228
      WBVar02157229
    Legacy_information: [cc615] : Defects in M lineage fate specification, randomisation of division planes in the M lineage. Fate transformation of coelomocytes and bodywall muscles to sex myoblasts in the M lineage. Sex myoblast migration defect. Person_evidence: WBPerson1659
    Strain: WBStrain00026332
      WBStrain00026335
      WBStrain00050587
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (39)
    Structured_description: Concise_description: mls-2 encodes a homeodomain protein of the HMX family; during postembryonic development, MLS-2 is required for cell proliferation, cleavage orientation, and fate specification in the mesodermal M lineage; in regulating M lineage proliferation and fate specification, MLS-2 appears to act upstream of CYE-1/cyclin E and HLH-1/CeMyoD, respectively, the latter of which is not expressed in the M lineage in mls-2 mutant animals; MLS-2 is expressed in the nuclei of early proliferating undifferentiated M lineage cells (up to the 8-M stage), in a subset of head neurons, and in cells near the vulva during the L2 and L3 larval stages. Paper_evidence: WBPaper00026712
          Curator_confirmed: WBPerson1843
          Date_last_updated: 01 Aug 2007 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment of mitotic spindle orientation; neuron differentiation involved in amphid sensory organ development; and regulation of cell differentiation. Located in nucleus. Expressed in several structures, including AB lineage cell; AWC-ON; M.dla; head; and somatic nervous system. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Is an ortholog of human HMX1 (H6 family homeobox 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060482 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5017)
  Molecular_info: Corresponding_CDS: C39E6.4
    Corresponding_transcript: C39E6.4.1
    Other_sequence: SS02421
      GRC01104_1
      Dviv_isotig26257
      GRC05667_1
      Oden_isotig28852
      SSC03100_1
      GR12274
      Acan_isotig07401
      JI172255.1
    Associated_feature (11)
    Transcription_factor: WBTranscriptionFactor000491
  Experimental_info: RNAi_result: WBRNAi00029684 Inferred_automatically: RNAi_primary
      WBRNAi00042212 Inferred_automatically: RNAi_primary
      WBRNAi00001129 Inferred_automatically: RNAi_primary
      WBRNAi00011782 Inferred_automatically: RNAi_primary
      WBRNAi00011781 Inferred_automatically: RNAi_primary
      WBRNAi00061153 Inferred_automatically: RNAi_primary
      WBRNAi00061154 Inferred_automatically: RNAi_primary
      WBRNAi00042211 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct: WBCnstr00011573
      WBCnstr00012615
      WBCnstr00013082
      WBCnstr00036150
      WBCnstr00041956
    Construct_product: WBCnstr00011573
      WBCnstr00014564
      WBCnstr00016326
      WBCnstr00022557
      WBCnstr00036150
    Antibody: WBAntibody00000863
    Microarray_results (23)
    Expression_cluster (146)
    Interaction: WBInteraction000004671
      WBInteraction000120660
      WBInteraction000124862
      WBInteraction000147581
      WBInteraction000164020
      WBInteraction000164094
      WBInteraction000168690
      WBInteraction000177474
      WBInteraction000182594
      WBInteraction000191980
      WBInteraction000193219
      WBInteraction000199958
      WBInteraction000202777
      WBInteraction000210872
      WBInteraction000215873
      WBInteraction000216773
      WBInteraction000220614
      WBInteraction000221945
      WBInteraction000223092
      WBInteraction000227700
      WBInteraction000229841
      WBInteraction000239267
      WBInteraction000241445
      WBInteraction000296674
      WBInteraction000310397
      WBInteraction000317786
      WBInteraction000318121
      WBInteraction000323748
      WBInteraction000334284
      WBInteraction000334978
      WBInteraction000335332
      WBInteraction000347353
      WBInteraction000351009
      WBInteraction000360509
      WBInteraction000368898
      WBInteraction000372499
      WBInteraction000376441
      WBInteraction000377033
      WBInteraction000377063
      WBInteraction000378251
      WBInteraction000382530
      WBInteraction000389917
      WBInteraction000391798
      WBInteraction000391996
      WBInteraction000392023
      WBInteraction000397017
      WBInteraction000401988
      WBInteraction000402211
      WBInteraction000411398
      WBInteraction000411581
      WBInteraction000414642
      WBInteraction000424962
      WBInteraction000426164
      WBInteraction000432503
      WBInteraction000438720
      WBInteraction000440521
      WBInteraction000441127
      WBInteraction000441710
      WBInteraction000446634
      WBInteraction000447009
      WBInteraction000447414
      WBInteraction000450662
      WBInteraction000451516
      WBInteraction000453542
      WBInteraction000455251
      WBInteraction000455816
      WBInteraction000457819
      WBInteraction000462277
      WBInteraction000502169
      WBInteraction000502723
      WBInteraction000503519
      WBInteraction000503670
      WBInteraction000503672
      WBInteraction000505292
      WBInteraction000505358
      WBInteraction000505536
      WBInteraction000505585
      WBInteraction000518566
      WBInteraction000524337
      WBInteraction000525161
      WBInteraction000525598
      WBInteraction000526060
      WBInteraction000526094
      WBInteraction000526295
      WBInteraction000526324
      WBInteraction000526362
      WBInteraction000526378
      WBInteraction000526546
      WBInteraction000526693
      WBInteraction000526694
      WBInteraction000526695
      WBInteraction000526696
      WBInteraction000526716
      WBInteraction000526951
      WBInteraction000527286
      WBInteraction000527352
      WBInteraction000527359
      WBInteraction000527373
      WBInteraction000527717
      WBInteraction000527995
      WBInteraction000528161
      WBInteraction000528230
      WBInteraction000528294
      WBInteraction000528300
      WBInteraction000528331
      WBInteraction000528366
      WBInteraction000528398
      WBInteraction000528420
      WBInteraction000528437
      WBInteraction000528473
      WBInteraction000528485
      WBInteraction000528514
      WBInteraction000528527
      WBInteraction000528538
      WBInteraction000528570
      WBInteraction000528590
      WBInteraction000528610
      WBInteraction000528644
      WBInteraction000528649
      WBInteraction000528669
      WBInteraction000528691
      WBInteraction000528730
      WBInteraction000528773
      WBInteraction000528897
      WBInteraction000528921
      WBInteraction000528932
      WBInteraction000528944
      WBInteraction000528969
      WBInteraction000528977
      WBInteraction000529004
      WBInteraction000529029
      WBInteraction000529034
      WBInteraction000529045
      WBInteraction000529136
      WBInteraction000529142
      WBInteraction000529149
      WBInteraction000529167
      WBInteraction000529199
      WBInteraction000529249
      WBInteraction000529268
      WBInteraction000529291
      WBInteraction000529297
      WBInteraction000529318
      WBInteraction000529337
      WBInteraction000529377
      WBInteraction000529423
      WBInteraction000529474
      WBInteraction000529498
      WBInteraction000529515
      WBInteraction000529541
      WBInteraction000529571
      WBInteraction000529579
      WBInteraction000529604
      WBInteraction000529642
      WBInteraction000529687
      WBInteraction000529708
      WBInteraction000529741
      WBInteraction000529762
      WBInteraction000529794
      WBInteraction000529874
      WBInteraction000529887
      WBInteraction000529972
      WBInteraction000530021
      WBInteraction000530075
      WBInteraction000530104
      WBInteraction000530137
      WBInteraction000530162
      WBInteraction000530215
      WBInteraction000530236
      WBInteraction000530285
      WBInteraction000530374
      WBInteraction000530413
      WBInteraction000530453
      WBInteraction000530540
      WBInteraction000530606
      WBInteraction000530640
      WBInteraction000530657
      WBInteraction000530703
      WBInteraction000530735
      WBInteraction000530777
      WBInteraction000530851
      WBInteraction000530866
      WBInteraction000530895
      WBInteraction000530922
      WBInteraction000530950
      WBInteraction000530999
      WBInteraction000531005
      WBInteraction000531084
      WBInteraction000531129
      WBInteraction000531161
      WBInteraction000531233
      WBInteraction000531267
      WBInteraction000531281
      WBInteraction000531292
      WBInteraction000531303
      WBInteraction000531371
      WBInteraction000531396
      WBInteraction000531403
      WBInteraction000531445
      WBInteraction000531481
      WBInteraction000531495
      WBInteraction000531511
      WBInteraction000531545
      WBInteraction000531685
      WBInteraction000531703
      WBInteraction000531735
      WBInteraction000531762
      WBInteraction000531838
      WBInteraction000531917
      WBInteraction000531933
      WBInteraction000531965
      WBInteraction000531979
      WBInteraction000532031
      WBInteraction000532118
      WBInteraction000532156
      WBInteraction000532176
      WBInteraction000532206
      WBInteraction000532271
      WBInteraction000532286
      WBInteraction000532305
      WBInteraction000532324
      WBInteraction000532356
      WBInteraction000532377
      WBInteraction000532401
      WBInteraction000532439
      WBInteraction000532444
      WBInteraction000532463
      WBInteraction000532498
      WBInteraction000532530
      WBInteraction000532547
      WBInteraction000532555
      WBInteraction000532579
      WBInteraction000532598
      WBInteraction000532629
      WBInteraction000532675
      WBInteraction000532692
      WBInteraction000532716
      WBInteraction000532746
      WBInteraction000532786
      WBInteraction000532831
      WBInteraction000532853
      WBInteraction000533075
      WBInteraction000533082
      WBInteraction000533142
      WBInteraction000533163
      WBInteraction000533215
      WBInteraction000533244
      WBInteraction000533281
      WBInteraction000533346
      WBInteraction000533406
      WBInteraction000533442
      WBInteraction000533476
      WBInteraction000533566
      WBInteraction000533575
      WBInteraction000533624
      WBInteraction000533645
      WBInteraction000533659
      WBInteraction000533678
      WBInteraction000533728
      WBInteraction000533771
      WBInteraction000533821
      WBInteraction000533892
      WBInteraction000533904
      WBInteraction000533926
      WBInteraction000533955
      WBInteraction000533974
      WBInteraction000534007
      WBInteraction000534082
      WBInteraction000534127
      WBInteraction000534181
      WBInteraction000534208
      WBInteraction000534221
      WBInteraction000534267
      WBInteraction000534273
      WBInteraction000534578
      WBInteraction000534644
      WBInteraction000534692
      WBInteraction000561295
  Map_info: Map: X Position: -6.69708 Error: 0.01114
    Positive: Positive_clone: C39E6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4493
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene