WormBase Tree Display for Gene: WBGene00003630
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| WBGene00003630 | Evidence | Paper_evidence | WBPaper00003416 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T03G6 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | nhr-40 | Person_evidence | WBPerson600 | |||||
| Sequence_name | T03G6.2 | ||||||||
| Molecular_name | T03G6.2b | ||||||||
| T03G6.2b.1 | |||||||||
| CE31228 | |||||||||
| T03G6.2c | |||||||||
| CE53506 | |||||||||
| T03G6.2c.1 | |||||||||
| Other_name | CELE_T03G6.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nhr-40 | ||||||||
| DB_info | Database | AceView | gene | XD225 | |||||
| WormQTL | gene | WBGene00003630 | |||||||
| WormFlux | gene | WBGene00003630 | |||||||
| NDB | locus_tag | CELE_T03G6.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003630|UniProtKB=Q22127 | |||||||
| family | PTHR24083 | ||||||||
| NCBI | gene | 180560 | |||||||
| RefSeq | protein | NM_001029702.5 | |||||||
| NM_001374979.2 | |||||||||
| SwissProt | UniProtAcc | Q22127 | |||||||
| TREEFAM | TREEFAM_ID | TF319915 | |||||||
| UniProt_GCRP | UniProtAcc | Q22127 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303074 | ||||
| Split_into | WBGene00303074 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhr | ||||||||
| Allele (165) | |||||||||
| Strain | WBStrain00031553 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (27) | |||||||||
| Paralog (216) | |||||||||
| Structured_description | Concise_description | nhr-40 encodes, by alternative splicing and promoters, three isoforms ofa nuclear hormone receptor specific to nematodes; NHR-40 is required fornormal development of bodywall muscles, and hence for normal movement;both nhr-40 promoters are active in body wall and pharygeal musclecells, as well as in some (perhaps non-overlapping) neurons of the headand ventral nerve cord; NHR-40 is a divergent ortholog of HNF4, with 17closely related paralogs in C. elegans belonging to the class 1,subgroup 8 of C. elegans NHRs with the P box sequence CNGCKT; nhr-40 ismost strongly transcribed in L2 larvae; nhr-40(RNAi), overexpression ofnhr-40 by heat shock, or the nhr-40(ok667) mutation all result indevelopmentally arrested embryos or larvae, with surviving larvae beingsmaller, abnormally bulging, and sluggish; nhr-40(RNAi) animals havedisorganized epithelial cells and missing body wall muscle cells;nhr-40(ok667) mutants are slow-moving and uncoordinated, frequentlyreversing direction or going in circles; transgenic expression of nhr-40cDNA in muscles rescues larval but not embryonic arrest. | Paper_evidence | WBPaper00005573 | |||||
| WBPaper00028428 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 12 Mar 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including P1; P2; egg-laying apparatus; rectal gland cell; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T03G6.2b | |||||||
| T03G6.2c | |||||||||
| Corresponding_CDS_history | T03G6.2a:wp272 | ||||||||
| T03G6.2c:wp272 | |||||||||
| T03G6.2d:wp264 | |||||||||
| Corresponding_transcript | T03G6.2b.1 | ||||||||
| T03G6.2c.1 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature (22) | |||||||||
| Transcription_factor | WBTranscriptionFactor000437 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00078892 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000541 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00052309 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035107 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078890 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078891 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4264 | ||||||||
| Expr4265 | |||||||||
| Expr4266 | |||||||||
| Expr1019811 | |||||||||
| Expr1031675 | |||||||||
| Expr1155945 | |||||||||
| Expr2014189 | |||||||||
| Expr2032430 | |||||||||
| Drives_construct | WBCnstr00011870 | ||||||||
| WBCnstr00011871 | |||||||||
| WBCnstr00011872 | |||||||||
| WBCnstr00035985 | |||||||||
| Construct_product | WBCnstr00035985 | ||||||||
| Regulate_expr_cluster | WBPaper00032009:nhr-40(ok667)_downregulated | ||||||||
| WBPaper00032009:nhr-40(ok667)_upregulated | |||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (32) | |||||||||
| Map_info | Map | X | Position | -14.2699 | Error | 0.099025 | |||
| Positive | Positive_clone | T03G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4787 | |||||||
| 4716 | |||||||||
| 4796 | |||||||||
| 5615 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00024845 | ||||||||
| WBPaper00026026 | |||||||||
| WBPaper00027309 | |||||||||
| WBPaper00027452 | |||||||||
| WBPaper00028428 | |||||||||
| WBPaper00030485 | |||||||||
| WBPaper00032009 | |||||||||
| WBPaper00036897 | |||||||||
| WBPaper00059540 | |||||||||
| WBPaper00063328 | |||||||||
| Remark | Sequence connections from Darin St. Louis [020930 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
