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WormBase Tree Display for Gene: WBGene00003639

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Name Class

WBGene00003639EvidencePaper_evidenceWBPaper00003416
SMapS_parentSequenceK10C3
IdentityVersion1
NameCGC_namenhr-49Person_evidenceWBPerson600
Sequence_nameK10C3.6
Molecular_name (17)
Other_nameCELE_K10C3.6Accession_evidenceNDBBX284601
Public_namenhr-49
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhr
Allele (78)
StrainWBStrain00031166
WBStrain00031167
WBStrain00031172
WBStrain00032408
WBStrain00034504
WBStrain00036136
WBStrain00040338
WBStrain00049816
WBStrain00051874
WBStrain00052029
RNASeq_FPKM (74)
GO_annotation (44)
Contained_in_operonCEOP1566
OrthologWBGene00057254Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00026621Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00159474Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00156923Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00134655Caenorhabditis japonicaFrom_analysisInparanoid_8
WormBase-Compara
WBGene00100746Pristionchus pacificusFrom_analysisInparanoid_8
WormBase-Compara
WBGene00225241Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g9940Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g7358Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g7283Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g7868Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g4544Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g19231Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g8127Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g5618Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g13340Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g3600Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g10535Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00001.g70Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-nhr-49Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g14848Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00070.g3265Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_17587Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_000715Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g13158Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g11438Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_10179000Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrI_pilon.g1920Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00236987Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00261828Strongyloides rattiFrom_analysisWormBase-Compara
ZFIN:ZDB-GENE-030131-1077Danio rerioFrom_analysisOMA
Panther
PhylomeDB
ZFIN:ZDB-GENE-060929-100Danio rerioFrom_analysisOMA
Panther
PhylomeDB
HGNC:5024Homo sapiensFrom_analysisOMA
Panther
PhylomeDB
MGI:109128Mus musculusFrom_analysisOMA
Panther
PhylomeDB
MGI:1353604Mus musculusFrom_analysisOMA
Panther
PhylomeDB
RGD:2810Rattus norvegicusFrom_analysisOMA
Panther
PhylomeDB
RGD:1310102Rattus norvegicusFrom_analysisOMA
Panther
PhylomeDB
Paralog (42)
Structured_descriptionConcise_descriptionnhr-49 encodes a nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRs; nhr-49 functions as a key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectively; NHR-49 activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts.Paper_evidenceWBPaper00003416
WBPaper00005655
WBPaper00024532
WBPaper00025114
WBPaper00026800
WBPaper00027365
Curator_confirmedWBPerson1843
Date_last_updated17 Mar 2009 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in determination of adult lifespan; positive regulation of transcription from RNA polymerase II promoter in response to stress; and regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. Expressed in hypodermis; intestinal cell; intestine; muscle cell; and neurons. Used to study alcohol use disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00041098
Curator_confirmedWBPerson324
Date_last_updated06 Jun 2019 00:00:00
DOID:9970Homo sapiensPaper_evidenceWBPaper00025114
Curator_confirmedWBPerson324
Date_last_updated20 Sep 2018 00:00:00
Potential_modelDOID:0111099Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:13809Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9993Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:1686Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:0080760Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
Models_disease_assertedWBDOannot00000610
WBDOannot00000707
WBDOannot00000708
Molecular_infoCorresponding_CDSK10C3.6a
K10C3.6b
K10C3.6c
K10C3.6d
K10C3.6e
Corresponding_transcriptK10C3.6a.1
K10C3.6a.2
K10C3.6b.1
K10C3.6b.2
K10C3.6c.1
K10C3.6d.1
K10C3.6e.1
Other_sequence (69)
Associated_feature (15)
Transcription_factorWBTranscriptionFactor000564
Experimental_infoRNAi_result (49)
Expr_patternExpr9486
Expr10378
Expr12144
Expr16231
Expr1021226
Expr1031683
Expr1154213
Expr2014198
Expr2032439
Drives_constructWBCnstr00015289
WBCnstr00020172
WBCnstr00035977
Construct_productWBCnstr00014051
WBCnstr00016239
WBCnstr00020172
WBCnstr00021645
WBCnstr00021647
WBCnstr00035977
Regulate_expr_clusterWBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061530:nhr-49(e2144)_upregulated
Microarray_results (39)
Expression_cluster (104)
SAGE_tag (12)
Interaction (374)
WBProcessWBbiopr:00000001
WBbiopr:00000121
Map_infoMapIPosition3.96404Error0.005389
PositivePositive_cloneK10C3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5149
4447
Pseudo_map_position
Reference (157)
PictureWBPicture0000013096
WBPicture0000013097
WBPicture0000013098
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene