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WormBase Tree Display for Gene: WBGene00003639

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Name Class

WBGene00003639EvidencePaper_evidenceWBPaper00003416
SMapS_parentSequenceK10C3
IdentityVersion1
NameCGC_namenhr-49Person_evidenceWBPerson600
Sequence_nameK10C3.6
Molecular_name (17)
Other_nameCELE_K10C3.6Accession_evidenceNDBBX284601
Public_namenhr-49
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhr
Allele (78)
StrainWBStrain00031166
WBStrain00031167
WBStrain00031172
WBStrain00032408
WBStrain00034504
WBStrain00036136
WBStrain00040338
WBStrain00049816
WBStrain00051874
WBStrain00052029
RNASeq_FPKM (74)
GO_annotation (44)
Contained_in_operonCEOP1566
Ortholog (37)
Paralog (42)
Structured_descriptionConcise_descriptionnhr-49 encodes a nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRs; nhr-49 functions as a key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectively; NHR-49 activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts.Paper_evidenceWBPaper00003416
WBPaper00005655
WBPaper00024532
WBPaper00025114
WBPaper00026800
WBPaper00027365
Curator_confirmedWBPerson1843
Date_last_updated17 Mar 2009 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in determination of adult lifespan; positive regulation of transcription from RNA polymerase II promoter in response to stress; and regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. Expressed in hypodermis; intestinal cell; intestine; muscle cell; and neurons. Used to study alcohol use disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00041098
Curator_confirmedWBPerson324
Date_last_updated06 Jun 2019 00:00:00
DOID:9970Homo sapiensPaper_evidenceWBPaper00025114
Curator_confirmedWBPerson324
Date_last_updated20 Sep 2018 00:00:00
Potential_modelDOID:0111099Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:13809Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9993Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:1686Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:0080760Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
Models_disease_assertedWBDOannot00000610
WBDOannot00000707
WBDOannot00000708
Molecular_infoCorresponding_CDSK10C3.6a
K10C3.6b
K10C3.6c
K10C3.6d
K10C3.6e
Corresponding_transcriptK10C3.6a.1
K10C3.6a.2
K10C3.6b.1
K10C3.6b.2
K10C3.6c.1
K10C3.6d.1
K10C3.6e.1
Other_sequence (69)
Associated_feature (15)
Transcription_factorWBTranscriptionFactor000564
Experimental_infoRNAi_result (49)
Expr_patternExpr9486
Expr10378
Expr12144
Expr16231
Expr1021226
Expr1031683
Expr1154213
Expr2014198
Expr2032439
Drives_constructWBCnstr00015289
WBCnstr00020172
WBCnstr00035977
Construct_productWBCnstr00014051
WBCnstr00016239
WBCnstr00020172
WBCnstr00021645
WBCnstr00021647
WBCnstr00035977
Regulate_expr_clusterWBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061530:nhr-49(e2144)_upregulated
Microarray_results (39)
Expression_cluster (104)
SAGE_tag (12)
Interaction (374)
WBProcessWBbiopr:00000001
WBbiopr:00000121
Map_infoMapIPosition3.96404Error0.005389
PositivePositive_cloneK10C3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5149
4447
Pseudo_map_position
ReferenceWBPaper00006412
WBPaper00024085
WBPaper00024111
WBPaper00024532
WBPaper00024849
WBPaper00025114
WBPaper00026800
WBPaper00027288
WBPaper00027309
WBPaper00027365
WBPaper00029038
WBPaper00030506
WBPaper00031723
WBPaper00031804
WBPaper00031850
WBPaper00031936
WBPaper00032077
WBPaper00033689
WBPaper00034498
WBPaper00034673
WBPaper00035159
WBPaper00035277
WBPaper00035452
WBPaper00035479
WBPaper00035560
WBPaper00036064
WBPaper00036476
WBPaper00036646
WBPaper00036736
WBPaper00037402
WBPaper00038124
WBPaper00038444
WBPaper00038491
WBPaper00039059
WBPaper00039085
WBPaper00039781
WBPaper00039827
WBPaper00040144
WBPaper00040181
WBPaper00040687
WBPaper00040998
WBPaper00042293
WBPaper00043037
WBPaper00043041
WBPaper00043072
WBPaper00043663
WBPaper00044077
WBPaper00044247
WBPaper00044281
WBPaper00044369
WBPaper00044571
WBPaper00045036
WBPaper00045355
WBPaper00046079
WBPaper00046225
WBPaper00046499
WBPaper00046784
WBPaper00046830
WBPaper00047527
WBPaper00047536
WBPaper00047559
WBPaper00047560
WBPaper00047572
WBPaper00047575
WBPaper00047661
WBPaper00048196
WBPaper00048993
WBPaper00049111
WBPaper00049168
WBPaper00049381
WBPaper00049466
WBPaper00050140
WBPaper00050715
WBPaper00051597
WBPaper00051611
WBPaper00052126
WBPaper00052391
WBPaper00052845
WBPaper00052868
WBPaper00053788
WBPaper00053798
WBPaper00055090
WBPaper00055319
WBPaper00055344
WBPaper00055390
WBPaper00055799
WBPaper00056224
WBPaper00056298
WBPaper00056739
WBPaper00056930
WBPaper00057009
WBPaper00057030
WBPaper00057271
WBPaper00057372
WBPaper00057422
WBPaper00057501
WBPaper00057527
WBPaper00057553
WBPaper00057952
WBPaper00058168
WBPaper00058576
WBPaper00059031
WBPaper00059111
WBPaper00059425
WBPaper00059578
WBPaper00059640
WBPaper00059722
WBPaper00059754
WBPaper00060060
WBPaper00060264
WBPaper00060760
WBPaper00060876
WBPaper00060921
WBPaper00060984
WBPaper00061361
WBPaper00061405
WBPaper00061501
WBPaper00061503
WBPaper00061530
WBPaper00061653
WBPaper00061738
WBPaper00061789
WBPaper00061861
WBPaper00061998
WBPaper00062224
WBPaper00062388
WBPaper00062492
WBPaper00062603
WBPaper00062625
WBPaper00062851
WBPaper00062858
WBPaper00063376
WBPaper00063912
WBPaper00064071
WBPaper00064093
WBPaper00064105
WBPaper00064156
WBPaper00064232
WBPaper00064339
WBPaper00064424
WBPaper00064498
WBPaper00064592
WBPaper00064601
WBPaper00064731
WBPaper00064763
WBPaper00064960
WBPaper00064979
WBPaper00065288
WBPaper00065312
WBPaper00065904
WBPaper00065941
WBPaper00065942
WBPaper00065988
WBPaper00066165
WBPaper00066191
WBPaper00066296
WBPaper00066299
PictureWBPicture0000013096
WBPicture0000013097
WBPicture0000013098
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene