WormBase Tree Display for Gene: WBGene00003639
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WBGene00003639 | Evidence | Paper_evidence | WBPaper00003416 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K10C3 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nhr | ||||||
Allele (78) | |||||||
Strain | WBStrain00031166 | ||||||
WBStrain00031167 | |||||||
WBStrain00031172 | |||||||
WBStrain00032408 | |||||||
WBStrain00034504 | |||||||
WBStrain00036136 | |||||||
WBStrain00040338 | |||||||
WBStrain00049816 | |||||||
WBStrain00051874 | |||||||
WBStrain00052029 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (44) | |||||||
Contained_in_operon | CEOP1566 | ||||||
Ortholog (37) | |||||||
Paralog (42) | |||||||
Structured_description | Concise_description | nhr-49 encodes a nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRs; nhr-49 functions as a key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectively; NHR-49 activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts. | Paper_evidence | WBPaper00003416 | |||
WBPaper00005655 | |||||||
WBPaper00024532 | |||||||
WBPaper00025114 | |||||||
WBPaper00026800 | |||||||
WBPaper00027365 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Mar 2009 00:00:00 | ||||||
Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in determination of adult lifespan; positive regulation of transcription from RNA polymerase II promoter in response to stress; and regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. Expressed in hypodermis; intestinal cell; intestine; muscle cell; and neurons. Used to study alcohol use disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00041098 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Jun 2019 00:00:00 | ||||||
DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00025114 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 20 Sep 2018 00:00:00 | ||||||
Potential_model | DOID:0111099 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | |||
DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
DOID:9993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
DOID:1686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
DOID:0080760 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5024) | ||||
Models_disease_asserted | WBDOannot00000610 | ||||||
WBDOannot00000707 | |||||||
WBDOannot00000708 | |||||||
Molecular_info | Corresponding_CDS | K10C3.6a | |||||
K10C3.6b | |||||||
K10C3.6c | |||||||
K10C3.6d | |||||||
K10C3.6e | |||||||
Corresponding_transcript | K10C3.6a.1 | ||||||
K10C3.6a.2 | |||||||
K10C3.6b.1 | |||||||
K10C3.6b.2 | |||||||
K10C3.6c.1 | |||||||
K10C3.6d.1 | |||||||
K10C3.6e.1 | |||||||
Other_sequence (69) | |||||||
Associated_feature (15) | |||||||
Transcription_factor | WBTranscriptionFactor000564 | ||||||
Experimental_info | RNAi_result (49) | ||||||
Expr_pattern | Expr9486 | ||||||
Expr10378 | |||||||
Expr12144 | |||||||
Expr16231 | |||||||
Expr1021226 | |||||||
Expr1031683 | |||||||
Expr1154213 | |||||||
Expr2014198 | |||||||
Expr2032439 | |||||||
Drives_construct | WBCnstr00015289 | ||||||
WBCnstr00020172 | |||||||
WBCnstr00035977 | |||||||
Construct_product | WBCnstr00014051 | ||||||
WBCnstr00016239 | |||||||
WBCnstr00020172 | |||||||
WBCnstr00021645 | |||||||
WBCnstr00021647 | |||||||
WBCnstr00035977 | |||||||
Regulate_expr_cluster | WBPaper00040134:nhr-49(RNAi)_regulated_protein | ||||||
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated | |||||||
WBPaper00061530:nhr-49(e2144)_downregulated | |||||||
WBPaper00061530:nhr-49(e2144)_upregulated | |||||||
Microarray_results (39) | |||||||
Expression_cluster (104) | |||||||
SAGE_tag (12) | |||||||
Interaction (374) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000121 | |||||||
Map_info | Map | I | Position | 3.96404 | Error | 0.005389 | |
Positive | Positive_clone | K10C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5149 | |||||
4447 | |||||||
Pseudo_map_position | |||||||
Reference (157) | |||||||
Picture | WBPicture0000013096 | ||||||
WBPicture0000013097 | |||||||
WBPicture0000013098 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |