WormBase Tree Display for Gene: WBGene00003807
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| WBGene00003807 | SMap | S_parent | Sequence | C39E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | npr-1 | Person_evidence | WBPerson42 | |||||
| Sequence_name | C39E6.6 | ||||||||
| Molecular_name | C39E6.6 | ||||||||
| C39E6.6.1 | |||||||||
| CE06941 | |||||||||
| Other_name | bor-1 | ||||||||
| CELE_C39E6.6 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | npr-1 | ||||||||
| DB_info | Database | AceView | gene | XF386 | |||||
| WormQTL | gene | WBGene00003807 | |||||||
| WormFlux | gene | WBGene00003807 | |||||||
| NDB | locus_tag | CELE_C39E6.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003807|UniProtKB=Q18534 | |||||||
| family | PTHR24235 | ||||||||
| NCBI | gene | 180752 | |||||||
| RefSeq | protein | NM_076415.6 | |||||||
| SwissProt | UniProtAcc | Q18534 | |||||||
| TREEFAM | TREEFAM_ID | TF350004 | |||||||
| UniProt_GCRP | UniProtAcc | Q18534 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | npr | ||||||||
| Reference_allele | WBVar00017601 | ||||||||
| Allele (52) | |||||||||
| Legacy_information | [de Bono M] npr-1 encodes predicted 467aa neuropeptide receptor ky13 is Q61stop, n1353 is G118D, ad609 is T83I,T144A. Natural variant g320 is V215F. | ||||||||
| [Leon Avery] Originally defined by the allele g320 from the Freiburg wild isolate RC301. Subsequently two alleles, ad609 and n1353, were isolated after EMS mutagenesis of N2. Another bor mutation, ky13, isolated by Heather in the Bargmann lab, produces a very similar phenotype, but has not been mapped or complementation tested. bor-1 worms have two phenotypes: they stay near the border of a bacterial lawn, and they clump together. (The clumping is difficult to see on standard 1.7% agar plates, because it leads rapidly to burrowing.) Both phenotypes are easier to see in dense bacterial lawns, and reduced or abolished when the mutants are grown on streptomycin-killed bacteria. Exposure to the odor of live bacteria restores the phenotype. RC301 has the strongest phenotype of all Bor strains, and its bor phenotype was reported to be semidominant. However, when the g320 mutation is moved into an N2 background by extensive backcrossing, it produces the weakest phenotype of the three alleles, and is clearly recessive, as are ad609 and n1353. RC301 therefore probably contains autosomal enhancers of the Bor phenotype. | |||||||||
| See also ad609, g320, n1353 | |||||||||
| Strain | WBStrain00022052 | ||||||||
| WBStrain00032029 | |||||||||
| WBStrain00000307 | |||||||||
| WBStrain00000303 | |||||||||
| WBStrain00005261 | |||||||||
| WBStrain00005474 | |||||||||
| WBStrain00005493 | |||||||||
| WBStrain00005498 | |||||||||
| WBStrain00022046 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Ortholog (32) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; in regulating social behavior, NPR-1 functions as a receptor for the FLP-18 and FLP-21 peptide ligands; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid. | Paper_evidence | WBPaper00003187 | |||||
| WBPaper00005157 | |||||||||
| WBPaper00005512 | |||||||||
| WBPaper00005661 | |||||||||
| WBPaper00006174 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Jul 2010 00:00:00 | ||||||||
| Automated_description | Enables neuropeptide receptor activity. Involved in several processes, including behavioral response to ethanol; social behavior; and thermotaxis. Located in axon; plasma membrane; and somatodendritic compartment. Expressed in excretory system; neurons; pharyngeal muscle cell; and preanal ganglion. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00013487 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 May 2019 00:00:00 | ||||||||
| Potential_model | DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4464) | |||||
| Models_disease_asserted | WBDOannot00000661 | ||||||||
| Molecular_info | Corresponding_CDS | C39E6.6 | |||||||
| Corresponding_transcript | C39E6.6.1 | ||||||||
| Other_sequence | JI171129.1 | ||||||||
| JI169959.1 | |||||||||
| FE911148.1 | |||||||||
| JO474499.1 | |||||||||
| HBC05302_1 | |||||||||
| ASC37229_1 | |||||||||
| EX914218.1 | |||||||||
| Acan_isotig20791 | |||||||||
| JI172860.1 | |||||||||
| BMC11576_1 | |||||||||
| Associated_feature | WBsf670459 | ||||||||
| WBsf1005064 | |||||||||
| WBsf1022847 | |||||||||
| WBsf237319 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00091291 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00072197 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042213 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011783 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1406 | ||||||||
| Expr1843 | |||||||||
| Expr2257 | |||||||||
| Expr11127 | |||||||||
| Expr12180 | |||||||||
| Expr13262 | |||||||||
| Expr1025782 | |||||||||
| Expr1146205 | |||||||||
| Expr2014405 | |||||||||
| Expr2032646 | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product (19) | |||||||||
| Regulate_expr_cluster | WBPaper00032196:npr-1(ad609)_downregulated | ||||||||
| WBPaper00032196:npr-1(ad609)_upregulated | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_1 | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_2 | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_3 | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_4 | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_5 | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_6 | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_7 | |||||||||
| WBPaper00049498:npr-1(ur89)_regulated_8 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (79) | |||||||||
| Interaction (108) | |||||||||
| Anatomy_function | WBbtf0121 | ||||||||
| WBbtf0435 | |||||||||
| WBProcess | WBbiopr:00000009 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | X | Position | -6.65773 | Error | 0.026475 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | syDf1 | |||||||
| Positive_clone | C39E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| F10A4 | |||||||||
| Mapping_data | 2_point | 3635 | |||||||
| 3636 | |||||||||
| Multi_point | 3710 | ||||||||
| 3711 | |||||||||
| 4493 | |||||||||
| Pos_neg_data | 9424 | ||||||||
| Reference (223) | |||||||||
| Remark | Data extracted from de Bono and Bargmann (1998) | ||||||||
| Method | Gene |
