WormBase Tree Display for Gene: WBGene00003996
expand all nodes | collapse all nodes | view schema
| WBGene00003996 | SMap | S_parent | Sequence | C34G6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pgp-2 | Person_evidence | WBPerson490 | |||||
| Sequence_name | C34G6.4 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | glo-5 | Paper_evidence | WBPaper00028970 | ||||||
| Person_evidence | WBPerson253 | ||||||||
| CELE_C34G6.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | pgp-2 | ||||||||
| DB_info | Database | AceView | gene | 1G471 | |||||
| WormQTL | gene | WBGene00003996 | |||||||
| WormFlux | gene | WBGene00003996 | |||||||
| NDB | locus_tag | CELE_C34G6.4 | |||||||
| Panther | gene | CAEEL|WormBase=C34G6.4b|UniProtKB=A0A0K3AQN5 | |||||||
| family | PTHR24221 | ||||||||
| NCBI | gene | 172262 | |||||||
| RefSeq | protein | NM_001313481.3 | |||||||
| NM_059306.7 | |||||||||
| NM_001313483.4 | |||||||||
| NM_001313482.3 | |||||||||
| TrEMBL | UniProtAcc | G5EDF9 | |||||||
| A0A0K3AQN5 | |||||||||
| A0A0K3AU66 | |||||||||
| A0A0K3AWK1 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A0K3AQN5 | |||||||
| OMIM | gene | 171050 | |||||||
| 171060 | |||||||||
| 603201 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 13 Jun 2007 17:00:45 | WBPerson2970 | Name_change | Other_name | glo-5 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele (94) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes P-glycoprotein, 61-65% identical to mammalian P-glycoproteins. Transcript slow in egg, higher subsequently. [Lincke et al. 1993; Nl] | ||||||||
| Strain | WBStrain00001117 | ||||||||
| WBStrain00003300 | |||||||||
| WBStrain00035530 | |||||||||
| WBStrain00007854 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (62) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family and that is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); during development, pgp-2 activity is required, in parallel with that of the AP-3 adaptor complex, for the proper formation of gut granules, lysosome-related organelles found in the C. elegans intestine; pgp-2 is expressed in the intestine, from the E2 stage of embryonic development through adulthood; PGP-2 localizes to the gut granule membrane. | Paper_evidence | WBPaper00001647 | |||||
| WBPaper00001717 | |||||||||
| WBPaper00028970 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 26 Nov 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in gut granule assembly and lipid storage. Located in gut granule membrane. Expressed in AWAL and AWAR. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info | Corresponding_CDS | C34G6.4a | |||||||
| C34G6.4b | |||||||||
| C34G6.4c | |||||||||
| C34G6.4d | |||||||||
| Corresponding_CDS_history | C34G6.4:wp177 | ||||||||
| Corresponding_transcript | C34G6.4a.1 | ||||||||
| C34G6.4b.1 | |||||||||
| C34G6.4c.1 | |||||||||
| C34G6.4d.1 | |||||||||
| Other_sequence (48) | |||||||||
| Associated_feature | WBsf656341 | ||||||||
| WBsf656342 | |||||||||
| WBsf656343 | |||||||||
| WBsf656344 | |||||||||
| WBsf717504 | |||||||||
| WBsf983795 | |||||||||
| WBsf1009879 | |||||||||
| WBsf217721 | |||||||||
| WBsf217722 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00000807 | ||||||||
| WBCnstr00002001 | |||||||||
| WBCnstr00003771 | |||||||||
| WBCnstr00006435 | |||||||||
| WBCnstr00011337 | |||||||||
| WBCnstr00012086 | |||||||||
| WBCnstr00015309 | |||||||||
| WBCnstr00016457 | |||||||||
| WBCnstr00035754 | |||||||||
| WBCnstr00042556 | |||||||||
| Construct_product | WBCnstr00012172 | ||||||||
| WBCnstr00035754 | |||||||||
| Antibody | WBAntibody00001204 | ||||||||
| WBAntibody00001205 | |||||||||
| WBAntibody00002121 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (28) | |||||||||
| Map_info | Map | I | Position | 0.472587 | Error | 0.000649 | |||
| Positive | Positive_clone | C34G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| PB#CPG8 | |||||||||
| Mapping_data | Multi_point | 4575 | |||||||
| 5068 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (36) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
