WormBase Tree Display for Gene: WBGene00003998
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| WBGene00003998 | SMap | S_parent | Sequence | F42E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-4 | Person_evidence | WBPerson490 | |||||
| Sequence_name | F42E11.1 | ||||||||
| Molecular_name | F42E11.1a | ||||||||
| F42E11.1a.1 | |||||||||
| CE44238 | |||||||||
| F42E11.1b | |||||||||
| CE03308 | |||||||||
| F42E11.1b.1 | |||||||||
| F42E11.1b.2 | |||||||||
| Other_name | CELE_F42E11.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pgp-4 | ||||||||
| DB_info | Database | AceView | gene | XL981 | |||||
| WormQTL | gene | WBGene00003998 | |||||||
| WormFlux | gene | WBGene00003998 | |||||||
| NDB | locus_tag | CELE_F42E11.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003998|UniProtKB=Q20331 | |||||||
| family | PTHR24221 | ||||||||
| NCBI | gene | 181327 | |||||||
| RefSeq | protein | NM_001270213.3 | |||||||
| NM_001270214.5 | |||||||||
| TrEMBL | UniProtAcc | Q20331 | |||||||
| D3KFS6 | |||||||||
| UniProt_GCRP | UniProtAcc | Q20331 | |||||||
| OMIM | gene | 171050 | |||||||
| 171060 | |||||||||
| 603201 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele (118) | |||||||||
| Legacy_information | [C.elegansII] pk34, pk82 : Tc1 insertions, no known phenotype.Encodes predicted 1265 aa P-glycoprotein similar to PGP-3 (75% identity). pgp-4:lacZexpressed only in excretory cell. [Lincke et al. 1992; NL] | ||||||||
| Strain | WBStrain00037123 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (55) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-4 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes; RNAi experiments demonstrate that pgp-4 is required for efficient RNAi in the germline; pgp-4 promoter-gfp fusion proteins are expressed in the larval excretory cell. | Paper_evidence | WBPaper00001647 | |||||
| WBPaper00002665 | |||||||||
| WBPaper00006421 | |||||||||
| WBPaper00024561 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 06 Mar 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and stress response to cadmium ion. Predicted to be located in plasma membrane. Expressed in excretory canal. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info | Corresponding_CDS | F42E11.1a | |||||||
| F42E11.1b | |||||||||
| Corresponding_CDS_history | F42E11.1:wp208 | ||||||||
| Corresponding_transcript | F42E11.1a.1 | ||||||||
| F42E11.1b.1 | |||||||||
| F42E11.1b.2 | |||||||||
| Other_sequence (76) | |||||||||
| Associated_feature | WBsf648538 | ||||||||
| WBsf1006976 | |||||||||
| WBsf1006977 | |||||||||
| WBsf1006978 | |||||||||
| WBsf1023857 | |||||||||
| WBsf236376 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00014821 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00047095 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00003784 | ||||||||
| WBCnstr00011340 | |||||||||
| WBCnstr00011341 | |||||||||
| WBCnstr00012129 | |||||||||
| WBCnstr00012130 | |||||||||
| WBCnstr00035752 | |||||||||
| Construct_product | WBCnstr00035752 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | X | Position | 3.27538 | Error | 0.044886 | |||
| Positive | Positive_clone | F42E11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| PB#CPG13 | |||||||||
| Mapping_data | Multi_point | 5493 | |||||||
| 4663 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Tc1 insertion polymorphism available. krb 04/03/02 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
