WormBase Tree Display for Gene: WBGene00004087
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| WBGene00004087 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F55A12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ppk-1 | Person_evidence | WBPerson683 | |||||
| Sequence_name | F55A12.3 | ||||||||
| Molecular_name | F55A12.3 | ||||||||
| F55A12.3.1 | |||||||||
| CE30541 | |||||||||
| F55A12.3.2 | |||||||||
| F55A12.3.3 | |||||||||
| Other_name | CELE_F55A12.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | ppk-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ppk | ||||||||
| Allele (72) | |||||||||
| Strain | WBStrain00036205 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP1240 | ||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00004088 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ppk-1 encodes a putative phosphatidylinositol-4-phosphate 5' kinase that is essential for ovulation, intense gonad sheath contraction and dilation of the spermathecal valve during oocyte maturation, and UNC-54 filament organization; more generally, PPK-1 is required for fertility, progression through larval development, normal locomotion and defecation, and overall health; defects of ppk-1(RNAi) animals in sterility, ovulation, and UNC-54 filaments are suppressed by the gain-of-function itr-1(sy290) allele, presumably through increased IP(3) signalling; PPK-1 is expressed in gonad sheath, spermatheca, uterine andvulva muscles, distal tip cells, intestine, head mesodermal cell, and many neurons (e.g., in the ventral nerve cord, near the nerve ring, and in tail); PPK-1 may be activated by VAV-1 and binds bovine calmodulin in vitro in a calcium-dependent manner; PPK-1 is orthologous to five human proteins (e.g., PIP5K1B, OMIM:602745), and distantly paralogous to PPK-2. | Paper_evidence | WBPaper00004402 | |||||
| WBPaper00006395 | |||||||||
| WBPaper00006525 | |||||||||
| WBPaper00024497 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00026850 | |||||||||
| WBPaper00029345 | |||||||||
| WBPaper00031011 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 04 May 2010 00:00:00 | ||||||||
| Automated_description | Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and calmodulin binding activity. Involved in protein localization and regulation of mitotic spindle elongation. Located in plasma membrane. Expressed in egg-laying apparatus; gonad; seam cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Is an ortholog of human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060653 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8996) | ||||
| Molecular_info | Corresponding_CDS | F55A12.3 | |||||||
| Corresponding_transcript | F55A12.3.1 | ||||||||
| F55A12.3.2 | |||||||||
| F55A12.3.3 | |||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf983666 | ||||||||
| WBsf983667 | |||||||||
| WBsf983668 | |||||||||
| WBsf983669 | |||||||||
| WBsf1009809 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Chronogram1937 | ||||||||
| Expr4663 | |||||||||
| Expr6189 | |||||||||
| Expr7820 | |||||||||
| Expr7821 | |||||||||
| Expr1017455 | |||||||||
| Expr1031971 | |||||||||
| Expr1152207 | |||||||||
| Expr2015016 | |||||||||
| Expr2033251 | |||||||||
| Drives_construct | WBCnstr00000572 | ||||||||
| WBCnstr00003606 | |||||||||
| WBCnstr00006427 | |||||||||
| WBCnstr00012157 | |||||||||
| WBCnstr00012944 | |||||||||
| WBCnstr00035708 | |||||||||
| Construct_product | WBCnstr00000572 | ||||||||
| WBCnstr00000573 | |||||||||
| WBCnstr00000574 | |||||||||
| WBCnstr00000575 | |||||||||
| WBCnstr00007662 | |||||||||
| WBCnstr00014478 | |||||||||
| WBCnstr00020776 | |||||||||
| WBCnstr00035708 | |||||||||
| Antibody | WBAntibody00001330 | ||||||||
| WBAntibody00001445 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (125) | |||||||||
| Map_info | Map | I | Position | -0.038613 | Error | 0.004702 | |||
| Positive | Positive_clone | F55A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5137 | |||||||
| 4234 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Sequence connection from [Weinkove D] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
