WormBase Tree Display for Gene: WBGene00004208
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| WBGene00004208 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZK675 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ptc-1 | Person_evidence | WBPerson349 | |||||
| Sequence_name | ZK675.1 | ||||||||
| Molecular_name | ZK675.1a | ||||||||
| ZK675.1a.1 | |||||||||
| CE42497 | |||||||||
| ZK675.1b | |||||||||
| CE52893 | |||||||||
| ZK675.1b.1 | |||||||||
| Other_name | CELE_ZK675.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ptc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ptc | ||||||||
| Allele (98) | |||||||||
| Strain | WBStrain00030766 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOP2320 | ||||||||
| Ortholog (44) | |||||||||
| Paralog (31) | |||||||||
| Structured_description | Concise_description | ptc-1 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTC-1 is required for cytokinesis in the germline, but not in somatic cells (the converse of PTR-2's function, and a role conserved in C. briggsae); PTC-1 is also required to isolate meiotic germline nuclei from one another so that their nuclear divisions are asynchronous; PTC-1 is (very weakly) required for normal molting; PTC-1 protein is found in the membranes of all germline cells except sperm; ptc-1 transcripts are present in germline, very early (2- and 4-cell) embryos, and in the germline precursor P4; ptc-1 null mutants have normal somatic tissues, but are sterile with multinucleate oocytes; murine PTCH is found in midbodies by mass tandem spectroscopy, indicating that PTC-1's function in cytokinesis may be conserved among metazoa; since PTC-1 has an SSD, PTC-1's core function may be to transport proteins, lipids, or sterols. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00004265 | |||||||||
| WBPaper00026841 | |||||||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 08 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in plasma membrane. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||||
| Accession_evidence | OMIM | 109400 | |||||||
| 605462 | |||||||||
| 610828 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Jan 2014 00:00:00 | ||||||||
| Potential_model (18) | |||||||||
| Disease_relevance | ptc-1 is similar to Drosophila Patched and human PTCH1 and is a receptor for the sonic hedgehog protein, both proteins are involved in development; human PTCH1 is also a tumor suppressor gene; mutations in human PTCH1 have been implicated in somatic basal cell carcinomas, Basal cell nevus syndrome (also called Gorlin syndrome, which includes skeletal abnormalities and an increased risk of developing various cancerous and noncancerous tumors) and Holoprosencephaly-7 (abnormal brain development, affecting the head and face); microRNA expression profiling studies in an transgenic elegans model of Parkinson''s disease, where human alpha-synuclein (A53T) is expressed, show that elegans ptc-1/PTCH1 is overexpressed; elegans ptc-1 is also overexpressed in the small non-coding RNAs, mir-64/mir-65 knockout worms for which it is a candidate target; mir-64 and mir-65 are themselves co-underexpressed in the alpha-synuclein model, suggesting that these small microRNAs may have a role in the pathogenesis of Parkinson''s disease. | Homo sapiens | Paper_evidence | WBPaper00035654 | |||||
| Accession_evidence | OMIM | 605462 | |||||||
| 109400 | |||||||||
| 610828 | |||||||||
| 601309 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 Jan 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000271 | ||||||||
| Molecular_info | Corresponding_CDS | ZK675.1a | |||||||
| ZK675.1b | |||||||||
| Corresponding_CDS_history | ZK675.1:wp189 | ||||||||
| Corresponding_transcript | ZK675.1a.1 | ||||||||
| ZK675.1b.1 | |||||||||
| Other_sequence (33) | |||||||||
| Associated_feature (36) | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr1012450 | ||||||||
| Expr1032065 | |||||||||
| Expr1163060 | |||||||||
| Expr2015143 | |||||||||
| Expr2033381 | |||||||||
| Drives_construct | WBCnstr00035636 | ||||||||
| Construct_product | WBCnstr00008499 | ||||||||
| WBCnstr00035636 | |||||||||
| Antibody | WBAntibody00001584 | ||||||||
| WBAntibody00001737 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (201) | |||||||||
| Interaction (88) | |||||||||
| WBProcess | WBbiopr:00000120 | ||||||||
| WBbiopr:00000123 | |||||||||
| Map_info | Map | II | Position | 0.601436 | Error | 0.002019 | |||
| Positive | Positive_clone | ZK675 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4611 | |||||||
| 5307 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
