WormBase Tree Display for Gene: WBGene00004249
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| WBGene00004249 | Evidence | Author_evidence | Persico MG | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y39A3CL | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pvf-1 | Person_evidence | WBPerson52 | |||||
| Sequence_name | Y39A3CL.6 | ||||||||
| Molecular_name | Y39A3CL.6 | ||||||||
| Y39A3CL.6.1 | |||||||||
| CE21657 | |||||||||
| Other_name | CELE_Y39A3CL.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | pvf-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pvf | ||||||||
| Allele (67) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | pvf-1 encodes a protein related to the VEGF family of growth factors; in C. elegans, PVF-1 functions in the male tail to regulate the position of the ray 1 sensillum via inhibition of UNC-40/DCC netrin signaling through the CED-10 GTPase; PVF-1 can bind the human VEGF receptors VEGFR1 (FLT) and VEGFR2 (KDR) and when expressed in chick embryos and human umbilical vein endothelial cells induces angiogenesis and capillary tube formation, respectively; a pvf-1 reporter fusion is expressed in dorsal and ventral body wall muscles, beginning at the first larval (L1) stage, with highest levels seen at the L3 stage and then slowly diminished levels in the adult. | Paper_evidence | WBPaper00044133 | |||||
| WBPaper00027066 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Apr 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable growth factor receptor binding activity. Involved in negative regulation of netrin-activated signaling pathway and nematode male tail tip morphogenesis. Predicted to be located in extracellular space. Expressed in body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; central nervous system cancer (multiple); diabetic retinopathy (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PDGFA (platelet derived growth factor subunit A) and PDGFB (platelet derived growth factor subunit B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (23) | ||||||||
| Molecular_info | Corresponding_CDS | Y39A3CL.6 | |||||||
| Corresponding_transcript | Y39A3CL.6.1 | ||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf650863 | ||||||||
| WBsf991398 | |||||||||
| WBsf226252 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00001355 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00036903 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020368 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056149 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11249 | ||||||||
| Expr1018398 | |||||||||
| Expr1032097 | |||||||||
| Expr1159659 | |||||||||
| Expr2015196 | |||||||||
| Expr2033430 | |||||||||
| Drives_construct | WBCnstr00018372 | ||||||||
| Antibody | WBAntibody00001055 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction | WBInteraction000033501 | ||||||||
| WBInteraction000033502 | |||||||||
| WBInteraction000034926 | |||||||||
| WBInteraction000049202 | |||||||||
| WBInteraction000230901 | |||||||||
| WBInteraction000520524 | |||||||||
| WBInteraction000566319 | |||||||||
| WBInteraction000566598 | |||||||||
| WBInteraction000573514 | |||||||||
| Map_info | Map | III | Position | -16.0058 | Error | 0.021738 | |||
| Positive | Positive_clone | Y39A3CL | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00018341 | ||||||||
| WBPaper00027066 | |||||||||
| WBPaper00033505 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00044133 | |||||||||
| WBPaper00052799 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00058524 | |||||||||
| WBPaper00061032 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
