WormBase Tree Display for Gene: WBGene00004373

WBGene00004373 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: W06H8
  Identity: Version: 1
    Name: CGC_name: rme-1 Person_evidence: WBPerson259
      Sequence_name: W06H8.1
      Molecular_name (30)
      Other_name: W06H8.e Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_W06H8.1 Accession_evidence: NDB BX284605
      Public_name: rme-1
    DB_info: Database: AceView gene 5G697
        WormQTL gene WBGene00004373
        WormFlux gene WBGene00004373
        NDB locus_tag CELE_W06H8.1
        Panther gene CAEEL|WormBase=WBGene00004373|UniProtKB=G5ECC3
          family PTHR11216
        NCBI gene 179010
        RefSeq protein NM_001356659.4
            NM_001356657.3
            NM_001029023.4
            NM_001029025.7
            NM_001392527.1
            NM_001356658.3
            NM_001029024.5
            NM_001392528.1
            NM_001380664.2
        TREEFAM TREEFAM_ID TF314429
        TrEMBL UniProtAcc A0A2C9C3Z4
            G5EFP1
            Q9N5B7
            Q8WSP1
            Q86S80
            A0A2C9C352
            G5ECC3
            A0A2C9C3S7
            G5EEU7
        UniProt_GCRP UniProtAcc G5ECC3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rme
    Allele (115)
    Legacy_information: [Grant BD] Brood Size: 207 Endocytosis of YP170 GFP by oocytes strongly reduced. Abundant pseudocoelomic yolk. b1021, b1045 intestinal vacuoles in adult hermaphrodites.
    Strain: WBStrain00005823
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (75)
    Paralog: WBGene00001224 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012696 Caenorhabditis elegans From_analysis: Panther
      WBGene00006405 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: rme-1 encodes a conserved, EPS15 homology (EH) domain-containing protein; RME-1 is required for endocytosis, specifically for modulating endocytic transport through the endosomal recycling compartment (ERC); RME-1 is ubiquitously expressed and, in the polarized intestinal epithelium, is found on basolateral recycling endosomes. Paper_evidence: WBPaper00004718
            WBPaper00004828
            WBPaper00004830
            WBPaper00004883
            WBPaper00030951
            WBPaper00035466
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 01 Sep 2010 00:00:00
      Automated_description: Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and necroptotic process. Located in recycling endosome membrane. Expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Is an ortholog of human EHD1 (EH domain containing 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: W06H8.1a
      W06H8.1b
      W06H8.1c
      W06H8.1d
      W06H8.1e
      W06H8.1f
      W06H8.1g
      W06H8.1h
      W06H8.1i
    Corresponding_CDS_history: W06H8.1b:wp261
    Corresponding_transcript (12)
    Other_sequence (119)
    Associated_feature (19)
  Experimental_info: RNAi_result: WBRNAi00080553 Inferred_automatically: RNAi_primary
      WBRNAi00102912 Inferred_automatically: RNAi_primary
      WBRNAi00069880 Inferred_automatically: RNAi_primary
      WBRNAi00102913 Inferred_automatically: RNAi_primary
      WBRNAi00065612 Inferred_automatically: RNAi_primary
      WBRNAi00069882 Inferred_automatically: RNAi_primary
      WBRNAi00069881 Inferred_automatically: RNAi_primary
      WBRNAi00102914 Inferred_automatically: RNAi_primary
      WBRNAi00054917 Inferred_automatically: RNAi_primary
      WBRNAi00102911 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1856
      Expr1346
      Expr1347
      Expr4948
      Expr6845
      Expr1019583
      Expr1032186
      Expr1158459
      Expr2015374
      Expr2033608
    Drives_construct: WBCnstr00003167
      WBCnstr00012361
      WBCnstr00035529
    Construct_product: WBCnstr00000154
      WBCnstr00000238
      WBCnstr00001777
      WBCnstr00001784
      WBCnstr00001824
      WBCnstr00001825
      WBCnstr00007131
      WBCnstr00007166
      WBCnstr00012361
      WBCnstr00035529
    Antibody: WBAntibody00000371
      WBAntibody00002187
    Microarray_results (54)
    Expression_cluster (155)
    SAGE_tag: SAGE:gtgatgaagaaggaagc Strand: Sense
        Unambiguously_mapped
      SAGE:tgctccttggcagctct Strand: Antisense
      SAGE:gttaagagca Strand: Sense
        Unambiguously_mapped
      SAGE:tctgacttgt Strand: Antisense
      SAGE:gttaagagcaaattacc Strand: Sense
        Unambiguously_mapped
      SAGE:gttgatcatc Strand: Sense
        Unambiguously_mapped
      SAGE:catcacagcaatgaatc Strand: Antisense
      SAGE:catcacagca Strand: Antisense
      SAGE:gttgatcatcaacagtt Strand: Sense
        Unambiguously_mapped
      SAGE:tgctccttgg Strand: Antisense
    Interaction (63)
  Map_info: Map: V Position: -0.210547 Error: 0.001622
    Well_ordered
    Positive: Inside_rearr: sDf30
      Positive_clone: W06H8 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf26
    Mapping_data: Multi_point: 3794
      Pos_neg_data: 10220
        10221
  Reference (71)
  Remark: Sequence connection from [Grant BD]
  Method: Gene