WormBase Tree Display for Gene: WBGene00004386

WBGene00004386 Evidence: Person_evidence: WBPerson71
      WBPerson395
  SMap: S_parent: Sequence: K08D10
  Identity: Version: 1
    Name: CGC_name: rnp-3 Person_evidence: WBPerson421
      Sequence_name: K08D10.3
      Molecular_name: K08D10.3a
        K08D10.3a.1
        CE07355
        K08D10.3b
        CE48959
        K08D10.3b.1
      Other_name: CELE_K08D10.3 Accession_evidence: NDB BX284604
      Public_name: rnp-3
    DB_info: Database: AceView gene 4E939
        WormQTL gene WBGene00004386
        WormFlux gene WBGene00004386
        NDB locus_tag CELE_K08D10.3
        Panther gene CAEEL|WormBase=WBGene00004386|UniProtKB=Q21323
          family PTHR10501
        NCBI gene 177182
        RefSeq protein NM_001307636.3
            NM_068104.6
        TrEMBL UniProtAcc Q21323
            U4PBX2
        UniProt_GCRP UniProtAcc Q21323
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rnp
    Allele (43)
    Strain: WBStrain00003826
      WBStrain00003827
      WBStrain00003828
      WBStrain00032007
    RNASeq_FPKM (74)
    GO_annotation (11)
    Contained_in_operon: CEOP4116
    Ortholog (39)
    Paralog: WBGene00003172 Caenorhabditis elegans From_analysis: Panther
      WBGene00004385 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: rnp-3 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-3/U2B''; genetically, rnp-3 appears to function redundantly with rnp-2/U1A: loss of rnp-3 activity alone results in low levels of embryonic and total lethality, while animals doubly mutant for rnp-3 and rnp-2/U1A show much higher levels of embryonic and total lethality; in addition, animals doubly mutant for SAP-1/U2A' and RNP-3/U2B'', display a much more severe phenotype than either single mutation, indicating that in vivo, these proteins have some independent functions; immunoprecipitation experiments indicate that RNP-3 associates with U2 RNA in vivo and that this association does not require the presence of SAP-1/U2A'. Paper_evidence: WBPaper00005959
            WBPaper00029444
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 22 Jan 2008 00:00:00
      Automated_description: Predicted to enable U1 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in Alzheimer's disease; connective tissue disease; and disease of cellular proliferation. Is an ortholog of human SNRPA (small nuclear ribonucleoprotein polypeptide A) and SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11151)
      DOID:14566 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11155)
      DOID:65 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11151,HGNC:11155)
  Molecular_info: Corresponding_CDS: K08D10.3a
      K08D10.3b
    Corresponding_transcript: K08D10.3a.1
      K08D10.3b.1
    Other_sequence (32)
    Associated_feature: WBsf996196
      WBsf996197
      WBsf1017199
      WBsf1017200
      WBsf228166
  Experimental_info: RNAi_result: WBRNAi00080121 Inferred_automatically: RNAi_primary
      WBRNAi00080032 Inferred_automatically: RNAi_primary
      WBRNAi00034119 Inferred_automatically: RNAi_primary
      WBRNAi00080033 Inferred_automatically: RNAi_primary
      WBRNAi00050253 Inferred_automatically: RNAi_primary
      WBRNAi00016786 Inferred_automatically: RNAi_primary
      WBRNAi00062312 Inferred_automatically: RNAi_primary
      WBRNAi00080120 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1014930
      Expr1032197
      Expr1153951
      Expr2015392
      Expr2033626
    Drives_construct: WBCnstr00000641
      WBCnstr00000642
      WBCnstr00035520
    Construct_product: WBCnstr00000641
      WBCnstr00000642
      WBCnstr00035520
    Microarray_results (20)
    Expression_cluster (104)
    SAGE_tag: SAGE:agaaaatgag Strand: Antisense
      SAGE:agaaaatgagattcaga Strand: Antisense
    Interaction (140)
  Map_info: Map: IV Position: -0.314107 Error: 0.046274
    Positive: Positive_clone: K08D10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4997
    Pseudo_map_position
  Reference: WBPaper00006465
    WBPaper00029444
    WBPaper00030488
    WBPaper00038354
    WBPaper00038491
    WBPaper00046432
    WBPaper00048543
    WBPaper00048771
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene