| WBGene00004393 | SMap | S_parent | Sequence | B0414 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | rnt-1 | Person_evidence | WBPerson83 |
| | | Sequence_name | B0414.2 |
| | | Molecular_name | B0414.2 |
| | | | B0414.2.1 |
| | | | CE24772 |
| | | | B0414.2.2 |
| | | | B0414.2.3 |
| | | Other_name | run | Accession_evidence | AF153275 |
| | | | mab-2 | Person_evidence | WBPerson759 |
| | | | | | WBPerson699 |
| | | | | | WBPerson3750 |
| | | | run-1 | Paper_evidence | WBPaper00003892 |
| | | | CELE_B0414.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | rnt-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rnt |
| | Reference_allele | WBVar00143855 |
| | Allele (143) |
| | Legacy_information | e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. |
| | | See also e1241 |
| | | [C.elegansII] e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages; bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal; late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. [Hodgkin 1983a; Link et al. 1988; CB] |
| | Strain | WBStrain00035360 |
| | | WBStrain00035361 |
| | | WBStrain00035362 |
| | | WBStrain00040727 |
| | | WBStrain00001748 |
| | | WBStrain00035579 |
| | | WBStrain00004456 |
| | | WBStrain00008477 |
| | | WBStrain00051045 |
| | RNASeq_FPKM (74) |
| | GO_annotation (36) |
| | Ortholog (46) |
| | Structured_description | Concise_description | rnt-1 encodes a transcription factor that is the sole C. elegans member of the Runx family of transcriptional regulators; rnt-1 activity is required for several developmental processes, including regulation of hypodermal seam cell proliferation and proper development of the male tail; rnt-1 mutant animals also exhibit a slight reduction in body size which is enhanced by starvation; RNT-1 can physically interact with SMA-4 and regulates, either directly or indirectly, expression of tlp-1 and cki-1, which encode a C2H2 zinc finger and CDK inhibitor, respectively; RNT-1::GFP reporter fusions are expressed in the nuclei of hypodermal seam cells and transiently in body wall muscles; in males, a RNT-1::GFP is expressed in cells derived from the V5, V6 and T lineages that give rise to the sensory rays. | Paper_evidence | WBPaper00005040 |
| | | | | | WBPaper00024401 |
| | | | | | WBPaper00026860 |
| | | | | | WBPaper00026868 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 03 Jan 2011 00:00:00 |
| | | Automated_description | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Expressed in body wall musculature; intestine; neurons; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and osteochondrodysplasia (multiple). Is an ortholog of human RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (23) |
| Molecular_info | Corresponding_CDS | B0414.2 |
| | Corresponding_transcript | B0414.2.1 |
| | | B0414.2.2 |
| | | B0414.2.3 |
| | Other_sequence | CBC12954_1 |
| | Associated_feature (23) |
| | Transcription_factor | WBTranscriptionFactor000199 |
| Experimental_info | RNAi_result | WBRNAi00065557 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00039038 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00028240 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063834 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064608 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063835 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00002853 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001354 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (22) |
| | Drives_construct (13) |
| | Construct_product | WBCnstr00010470 |
| | | WBCnstr00011148 |
| | | WBCnstr00012390 |
| | | WBCnstr00012969 |
| | | WBCnstr00016840 |
| | | WBCnstr00018817 |
| | | WBCnstr00018818 |
| | | WBCnstr00022571 |
| | | WBCnstr00035514 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1678 |
| | | WBPaper00032425:down_in_alg-1 |
| | | WBPaper00032425:down_in_rde-4 |
| | | WBPaper00032425:down_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033070:Elbe_downregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037946:EGL-5_interacting |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L3 |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00049377:MWCNT_downregulated |
| | | WBPaper00049635:dop-1(vs100)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_upregulated_100-cell-embryo |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053318:Aging_upregulated_mRNA_N2 |
| | | WBPaper00053318:mir-71(n4115)_upregulated_mRNA |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053810:sod-2(ok1030)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057068:ints-4(RNAi)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:cfz-2_18944-cfz-2_2268 |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064156:lipl-4(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064532:pals-25(icb98)_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065086:JU1400_N.ironsii_regulated |
| | | WBPaper00065086:JU1400_N.parisii_regulated |
| | | WBPaper00065086:N2_N.ferruginous_regulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065734:unc-25(e156)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_WT |
| | | cgc4489_group_12 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00032948:StarveUp1 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00041267:SpaceFlight_Downregulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (127) |
| | WBProcess | WBbiopr:00000025 |
| | | WBbiopr:00000073 |
| | | WBbiopr:00000112 |
| Map_info | Map | I | Position | 0.447019 | Error | 0.000263 |
| | Positive | Positive_clone | B0414 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 329 |
| | | Multi_point | 205 |
| | | | 4641 |
| | | | 5090 |
| Reference (75) |
| Remark |
| Method | Gene |
