WormBase Tree Display for Gene: WBGene00004457
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| WBGene00004457 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C01B7 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | rpm-1 | Person_evidence | WBPerson451 | |||||
| Sequence_name | C01B7.6 | ||||||||
| Molecular_name | C01B7.6 | ||||||||
| C01B7.6.1 | |||||||||
| CE06730 | |||||||||
| Other_name | rpm-3 | ||||||||
| sam-1 | |||||||||
| sad-3 | |||||||||
| syd-3 | |||||||||
| CELE_C01B7.6 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | rpm-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rpm | ||||||||
| Allele (126) | |||||||||
| Strain | WBStrain00005412 | ||||||||
| WBStrain00001745 | |||||||||
| WBStrain00029055 | |||||||||
| WBStrain00029056 | |||||||||
| WBStrain00031377 | |||||||||
| WBStrain00005362 | |||||||||
| WBStrain00037463 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (74) | |||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00017190 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | rpm-1 encodes an E3 ubiquitin ligase that contains an N-terminal RCC1 (regulator of chromosome condensation)-like guanine nucleotide exchange factor (GEF) domain and that is orthologous to Drosophila highwire and murine Phr1; RPM-1 functions autonomously within several different types of neurons to regulate presynaptic differentiation; in regulating axon termination, RPM-1 acts through the GLO-4 guanine nucleotide exchange factor that positively regulates vesicular trafficking through GLO-1/Rab; in regulating synaptogenesis, RPM-1 functions as part of an SCF-like ubiquitin ligase complex that negatively regulates signaling through the DLK-1 MAP kinase cascade; RPM-1 is expressed in most, if not all, neurons from the comma stage of embryogenesis through adulthood; RPM-1 expression is also seen in the pharynx, coelomocytes, and distal tip cells; in neurons, RPM-1 localizes to presynaptic terminals. | Paper_evidence | WBPaper00004146 | |||||
| WBPaper00004147 | |||||||||
| WBPaper00024212 | |||||||||
| WBPaper00024955 | |||||||||
| WBPaper00030940 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Nov 2007 00:00:00 | ||||||||
| Automated_description | Enables mitogen-activated protein kinase kinase kinase binding activity; protein phosphatase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intracellular signal transduction; regulation of neuron projection development; and regulation of synapse assembly. Located in axon; neuromuscular junction; and presynaptic periactive zone. Expressed in several structures, including coelomocyte; hermaphrodite distal tip cell; nerve ring; pharynx; and touch receptor neurons. Is an ortholog of human MYCBP2 (MYC binding protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C01B7.6 | |||||||
| Corresponding_transcript | C01B7.6.1 | ||||||||
| Other_sequence (42) | |||||||||
| Associated_feature | WBsf669186 | ||||||||
| WBsf669187 | |||||||||
| WBsf669188 | |||||||||
| WBsf669189 | |||||||||
| WBsf234135 | |||||||||
| WBsf234136 | |||||||||
| WBsf234137 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00000713 | ||||||||
| WBCnstr00002560 | |||||||||
| WBCnstr00006401 | |||||||||
| WBCnstr00010055 | |||||||||
| WBCnstr00021120 | |||||||||
| WBCnstr00035471 | |||||||||
| Construct_product | WBCnstr00000717 | ||||||||
| WBCnstr00006401 | |||||||||
| WBCnstr00019627 | |||||||||
| WBCnstr00021081 | |||||||||
| WBCnstr00021082 | |||||||||
| WBCnstr00021120 | |||||||||
| WBCnstr00021121 | |||||||||
| WBCnstr00035471 | |||||||||
| WBCnstr00040000 | |||||||||
| WBCnstr00041440 | |||||||||
| Antibody | WBAntibody00000282 | ||||||||
| WBAntibody00001369 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (111) | |||||||||
| WBProcess | WBbiopr:00000117 | ||||||||
| Map_info | Map | V | Position | 1.62029 | Error | 0.012923 | |||
| Positive | Positive_clone | C01B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4092 | |||||||
| 4093 | |||||||||
| Pos_neg_data | 10723 | ||||||||
| 10724 | |||||||||
| 10725 | |||||||||
| 10726 | |||||||||
| 10727 | |||||||||
| Reference (123) | |||||||||
| Remark | Sequence connection from [Jin Y, Nonet M] | ||||||||
| old_name sam-1 becomes new_name rpm-1 from [Jin Y, Nonet M]. | |||||||||
| [email 93 from R. Lee and cgc4523] | |||||||||
| Sequence connection from [Zhen M] | |||||||||
| Method | Gene |
