WormBase Tree Display for Gene: WBGene00004732

WBGene00004732 SMap: S_parent: Sequence: C18F3
  Identity: Version: 1
    Name: CGC_name: sax-7 Person_evidence: WBPerson42
      Sequence_name: C18F3.2
      Molecular_name (18)
      Other_name: lad-1 CGC_data_submission
        CELE_C18F3.2 Accession_evidence: NDB BX284604
      Public_name: sax-7
    DB_info: Database: WormQTL gene WBGene00004732
        WormFlux gene WBGene00004732
        NDB locus_tag CELE_C18F3.2
        NCBI gene 177602
        RefSeq protein NM_001038308.4
            NM_001038306.6
            NM_001307233.3
            NM_001038307.5
            NM_001038305.3
            NM_001307232.3
        TrEMBL UniProtAcc W6RRX6
            Q4PIU9
            W6RTH3
            Q53U86
            Q53U87
            Q18100
        UniProt_GCRP UniProtAcc Q53U87
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sax
    Allele: WBVar00145218 Inferred_automatically: From strain object: LH2
      WBVar00603900 Inferred_automatically: From strain object: LH81
      WBVar00092492 Inferred_automatically: From strain object: RB1199
      WBVar02157602
      WBVar02157603
      WBVar02157604
      WBVar02157605
      WBVar02158369
      WBVar02158375
      WBVar02158321
      WBVar02158425
      WBVar02158426
      WBVar02158543
      WBVar02057838
      WBVar00924878
      WBVar00924879
      WBVar02057839
      WBVar02057840
      WBVar00924880
      WBVar02057841
      WBVar00924881
      WBVar01923751
      WBVar02057842
      WBVar00924882
      WBVar00924883
      WBVar02057843
      WBVar00924884
      WBVar00250441
      WBVar02057844
      WBVar00924885
      WBVar02057845
      WBVar02057846
      WBVar01853637
      WBVar01853638
      WBVar01853639
      WBVar01853640
      WBVar01500079
      WBVar00088408
      WBVar01853641
      WBVar01853642
      WBVar01853643
      WBVar01853644
      WBVar01853645
      WBVar01853646
      WBVar02013517
      WBVar01853647
      WBVar01853648
      WBVar01853649
      WBVar01853650
      WBVar01853651
      WBVar02055821
      WBVar00091276
      WBVar01853652
      WBVar01853653
      WBVar01853654
      WBVar01853655
      WBVar01853656
      WBVar01853657
      WBVar01853658
      WBVar00091283
      WBVar01853659
      WBVar00091286
      WBVar00091287
      WBVar01853660
      WBVar01853661
      WBVar02125303
      WBVar01730003
      WBVar01853662
      WBVar01730004
      WBVar01853663
      WBVar01730005
      WBVar01853664
      WBVar01730006
      WBVar01853665
      WBVar01853666
      WBVar01730007
      WBVar01853667
      WBVar01730008
      WBVar01853668
      WBVar01730009
      WBVar01853669
      WBVar01730010
      WBVar01730011
      WBVar01730012
      WBVar02071014
      WBVar02071015
      WBVar01453250
      WBVar01453251
      WBVar00190961
      WBVar01453252
      WBVar00190962
      WBVar01453253
      WBVar01794882
      WBVar00190963
      WBVar01453254
      WBVar00190964
      WBVar00190965
      WBVar01453255
      WBVar01453256
      WBVar01453257
      WBVar00304412
      WBVar00304413
      WBVar01453258
      WBVar01499395
      WBVar01499396
      WBVar01990913
      WBVar02109071
      WBVar00924779
      WBVar00924780
      WBVar01482121
      WBVar00924781
      WBVar01482122
      WBVar00254582
      WBVar00924782
      WBVar01482123
      WBVar00254583
      WBVar00924783
      WBVar00924784
      WBVar00924785
      WBVar00429855
      WBVar00429856
      WBVar00924786
      WBVar00429857
      WBVar00924787
      WBVar00924788
      WBVar00429858
      WBVar00429859
      WBVar00924789
      WBVar00924790
      WBVar00429860
      WBVar00924791
      WBVar00429861
      WBVar00429862
      WBVar00924792
      WBVar02036959
      WBVar00429863
      WBVar00924793
      WBVar00429864
      WBVar02036960
      WBVar00924794
      WBVar00924795
      WBVar00429865
      WBVar00924796
      WBVar00429866
      WBVar00429867
      WBVar00924797
      WBVar00924798
      WBVar00429868
      WBVar00429869
      WBVar00924799
      WBVar00429870
      WBVar00924800
      WBVar00429871
      WBVar00924801
      WBVar01833341
      WBVar00429872
      WBVar00924802
      WBVar01710265
      WBVar00924803
      WBVar00429873
      WBVar00429874
      WBVar00924804
      WBVar00429875
      WBVar00924805
      WBVar00924806
      WBVar00429876
      WBVar00429877
      WBVar00924807
      WBVar00429878
      WBVar00924808
      WBVar00429879
      WBVar00924809
      WBVar00429880
      WBVar00924810
      WBVar01499633
      WBVar00924811
      WBVar00429881
      WBVar00924812
      WBVar00429882
      WBVar02003871
      WBVar00924813
      WBVar00429883
      WBVar00924814
      WBVar00429884
      WBVar00924815
      WBVar00429885
      WBVar00924816
      WBVar00429886
      WBVar00573607
      WBVar00924817
      WBVar00429887
      WBVar00924818
      WBVar00429888
      WBVar00429889
      WBVar00924819
      WBVar00924820
      WBVar00924821
      WBVar02149846
      WBVar00924822
      WBVar00924823
      WBVar00924824
      WBVar00924825
      WBVar00924826
      WBVar00924827
      WBVar00924828
      WBVar00924829
      WBVar00924830
      WBVar00924831
      WBVar00924832
      WBVar00924833
      WBVar00924834
      WBVar00924835
      WBVar00924836
      WBVar01966674
      WBVar00924837
      WBVar01966675
      WBVar00924838
      WBVar02020941
      WBVar01966676
      WBVar00924839
      WBVar02020942
      WBVar02020943
      WBVar01966677
      WBVar00924840
      WBVar00924841
      WBVar00924842
      WBVar00924843
      WBVar00924844
      WBVar00924845
      WBVar00924846
      WBVar00924847
      WBVar00924848
      WBVar00924849
      WBVar00924850
      WBVar00924851
      WBVar00924852
      WBVar00924853
      WBVar00924854
      WBVar00924855
      WBVar00924856
      WBVar00305572
      WBVar00305573
      WBVar00924857
      WBVar00924858
      WBVar00924859
      WBVar00924860
      WBVar00924861
      WBVar00924862
      WBVar00924863
      WBVar00924864
      WBVar00924865
      WBVar02148214
      WBVar00924866
      WBVar00924867
      WBVar00924868
      WBVar00924869
      WBVar00924870
      WBVar00924871
      WBVar02134245
      WBVar01500245
      WBVar00924872
      WBVar02134246
      WBVar02134247
      WBVar00924873
      WBVar00924874
      WBVar02011579
      WBVar00924875
      WBVar00924876
      WBVar02057837
      WBVar00924877
    Strain (17)
    RNASeq_FPKM (74)
    GO_annotation (41)
    Ortholog (40)
    Paralog (24)
    Structured_description: Concise_description: sax-7 encodes an ortholog of human L1CAM, and a paralog of lad-2; L1CAM is a member of the group of highly conserved transmembrane cell adhesion receptor molecules which belong to the immunuglobulin superfamily; SAX-7 is required for axon guidance, neurite outgrowth and maintenance of neuronal positioning through homophilic and heterophilic interactions; sax-7 also affects germline development, embryonic morphogenesis, gonadal morphogenesis and tissue attachment; SAX-7 function is regulated by its physical interaction with the ankyrin UNC-44, and the gamma-syntrophin STN-2; nonphosphorylated SAX-7 is ubiquitously expressed at sites of cell-cell contact and colocalizes with UNC-44. Paper_evidence: WBPaper00004127
            WBPaper00004840
            WBPaper00026686
            WBPaper00032183
            WBPaper00025149
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 03 Jun 2007 00:00:00
      Automated_description: Enables ankyrin binding activity. Involved in several processes, including cell development; establishment of mitotic spindle orientation; and regulation of cell morphogenesis. Located in several cellular components, including axolemma; lateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including gonad; neurons; pharynx; somatic nervous system; and vulval cell. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0060246
    Potential_model: DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1939)
  Models_disease_asserted: WBDOannot00000053
  Molecular_info: Corresponding_CDS: C18F3.2a
      C18F3.2b
      C18F3.2c
      C18F3.2d
      C18F3.2e
      C18F3.2f
    Corresponding_CDS_history: C18F3.2:wp129
      C18F3.2:wp145
    Corresponding_transcript: C18F3.2a.1
      C18F3.2b.1
      C18F3.2c.1
      C18F3.2d.1
      C18F3.2e.1
      C18F3.2f.1
    Other_sequence (58)
    Associated_feature (50)
  Experimental_info: RNAi_result: WBRNAi00101409 Inferred_automatically: RNAi_primary
      WBRNAi00040967 Inferred_automatically: RNAi_primary
      WBRNAi00110314 Inferred_automatically: RNAi_primary
      WBRNAi00011018 Inferred_automatically: RNAi_primary
      WBRNAi00001509 Inferred_automatically: RNAi_primary
    Expr_pattern (20)
    Drives_construct: WBCnstr00001457
      WBCnstr00001458
      WBCnstr00001459
      WBCnstr00001460
      WBCnstr00017300
      WBCnstr00018436
      WBCnstr00040218
      WBCnstr00041183
      WBCnstr00042159
    Construct_product (15)
    Antibody: WBAntibody00000401
      WBAntibody00000402
      WBAntibody00000403
      WBAntibody00002176
    Microarray_results (39)
    Expression_cluster (184)
    Interaction (99)
    WBProcess: WBbiopr:00000073
  Map_info: Map: IV Position: 3.5916 Error: 0.001877
    Positive: Positive_clone: C18F3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4049
        4986
        4999
        5613
  Reference (102)
  Remark: Description and Allele (ky146) data extracted from Zallen JA, Kirch SA, Bargmann CI [ck1 020828]
    Sequence connection from [Chen L, Bennett V]
    lad-1 was merged into this gene following advice from the CGC [030902 krb]
  Method: Gene