WormBase Tree Display for Gene: WBGene00004760

WBGene00004760 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 2
    Name: CGC_name: sel-2 Person_evidence: WBPerson220
      Sequence_name: F10F2.1
      Molecular_name: F10F2.1a
        F10F2.1a.1
        CE32621
        F10F2.1b
        CE53968
        F10F2.1b.1
      Other_name: CELE_F10F2.1 Accession_evidence: NDB BX284603
      Public_name: sel-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Feb 2007 16:45:24 WBPerson2970 Event: Acquires_merge: WBGene00008653
      Acquires_merge: WBGene00008653
    Status: Live
  Gene_info (11)
  Disease_info: Experimental_model: DOID:0060041 Homo sapiens Paper_evidence: WBPaper00028987
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 May 2017 00:00:00
    Potential_model: DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7648)
      DOID:0081151 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1742)
    Disease_relevance: A disruption in the gene encoding Human Neurobeachin (LRBA), a protein involved in neuronal membrane protein traffic, is associated with Autism; studies of the elegans ortholog, sel-2, support Neurobeachin''s role in vesicle transport and show that sel-12/Neurobeachin is involved in cell surface protein delivery to the lysosome; sel-2 is also a negative regulator of Notch/lin-12 activity. Homo sapiens Paper_evidence: WBPaper00028987
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 May 2017 00:00:00
  Models_disease_in_annotation: WBDOannot00000164
  Molecular_info: Corresponding_CDS: F10F2.1a
      F10F2.1b
    Corresponding_transcript: F10F2.1a.1
      F10F2.1b.1
    Other_sequence (50)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00116198 Inferred_automatically: RNAi_primary
      WBRNAi00077447 Inferred_automatically: RNAi_primary
      WBRNAi00000779 Inferred_automatically: RNAi_primary
      WBRNAi00005062 Inferred_automatically: RNAi_primary
      WBRNAi00077452 Inferred_automatically: RNAi_primary
      WBRNAi00030781 Inferred_automatically: RNAi_primary
      WBRNAi00044286 Inferred_automatically: RNAi_primary
      WBRNAi00116216 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr122
      Expr4502
      Expr4503
      Expr1026952
      Expr1032356
      Expr1148234
      Expr2015733
      Expr2033966
    Drives_construct: WBCnstr00012065
      WBCnstr00012066
      WBCnstr00035404
    Construct_product: WBCnstr00012066
      WBCnstr00035404
    Microarray_results (18)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00034640:Phosphorylated_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050743:elli-1(sam-3)_downregulated
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056826:SGP_biased
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:CEPsh
      WBPaper00061340:mc3
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:RIA_parent
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00062056:lin-15B(n744)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      cgc4489_group_9
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036286:Pattern_G
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (55)
  Map_info: Map: III Position: -2.97863 Error: 0.007799
    Well_ordered
    Positive: Inside_rearr: sDf121
      Positive_clone: F10F2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 1503
        1504
        2799
        2800
        3577
        3578
        3579
      Pos_neg_data: 9164
  Reference: WBPaper00001833
    WBPaper00010621
    WBPaper00026071
    WBPaper00027276
    WBPaper00028987
    WBPaper00035925
    WBPaper00038491
    WBPaper00047387
    WBPaper00055090
    WBPaper00061833
  Method: Gene