WormBase Tree Display for Gene: WBGene00004765
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| WBGene00004765 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C32A3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sel-8 | Person_evidence | WBPerson220 | |||||
| Sequence_name | C32A3.1 | ||||||||
| Molecular_name | C32A3.1a | ||||||||
| C32A3.1a.1 | |||||||||
| CE27810 | |||||||||
| C32A3.1b | |||||||||
| CE01505 | |||||||||
| C32A3.1b.1 | |||||||||
| Other_name | pqn-17 | ||||||||
| lag-3 | |||||||||
| CELE_C32A3.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | sel-8 | ||||||||
| DB_info | Database | AceView | gene | 3E704 | |||||
| WormQTL | gene | WBGene00004765 | |||||||
| SignaLink | protein | WBGene00004765 | |||||||
| WormFlux | gene | WBGene00004765 | |||||||
| NDB | locus_tag | CELE_C32A3.1 | |||||||
| NCBI | gene | 175464 | |||||||
| RefSeq | protein | NM_001026024.4 | |||||||
| NM_001384056.2 | |||||||||
| SwissProt | UniProtAcc | Q09260 | |||||||
| TREEFAM | TREEFAM_ID | TF317118 | |||||||
| UniProt_GCRP | UniProtAcc | Q09260 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sel | ||||||||
| Allele (290) | |||||||||
| Legacy_information | [Tax FE] Nearly recessive suppressor of dominant egg-laying defect of lin-12(n302); cold-sensitive maternal effect lethal; dominant enhancer of glp-1((e2142) | ||||||||
| Complementation_data | [Tax FE] complements emb-1(hc57), emb-2(hc58), emb-7(hc66), emb-8(hc69), emb-32(g58) | ||||||||
| Strain | WBStrain00022823 | ||||||||
| WBStrain00035670 | |||||||||
| WBStrain00051998 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Contained_in_operon | CEOP3862 | ||||||||
| Ortholog (19) | |||||||||
| Structured_description | Concise_description | sel-8 encodes a nuclear protein required for GLP-1 and LIN-12 signalling, that is analogous to (and may be homologous to) Drosophila MASTERMIND and its mammalian orthologs; SEL-8 (also known as LAG-3) forms a ternary complex with LAG-1/Su(H) and the intracellular domain of either GLP-1 or LIN-12; like MAM, SEL-8 is glutamine- and proline-rich; SEL-8 contains a novel motif shared with W09C5.1 and orthologs of W09C5.1 in S. cerevisiae (YER126c), Drosophila (DMIP259), and also has two prominent glutamine-rich domains. | Paper_evidence | WBPaper00004120 | |||||
| WBPaper00004207 | |||||||||
| WBPaper00005068 | |||||||||
| WBPaper00006099 | |||||||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor binding activity; Notch binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of stem cell proliferation; and regulation of mesodermal cell fate specification. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C32A3.1a | |||||||
| C32A3.1b | |||||||||
| Corresponding_transcript | C32A3.1a.1 | ||||||||
| C32A3.1b.1 | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature (27) | |||||||||
| Experimental_info | RNAi_result (59) | ||||||||
| Expr_pattern | Expr1109 | ||||||||
| Expr2428 | |||||||||
| Expr1028582 | |||||||||
| Expr1032359 | |||||||||
| Expr1145663 | |||||||||
| Expr2015736 | |||||||||
| Expr2033969 | |||||||||
| Drives_construct | WBCnstr00000051 | ||||||||
| WBCnstr00000579 | |||||||||
| Construct_product | WBCnstr00010824 | ||||||||
| Antibody | WBAntibody00001215 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (82) | |||||||||
| Interaction (41) | |||||||||
| WBProcess | WBbiopr:00000072 | ||||||||
| Map_info | Map | III | Position | -5.16439 | Error | 0.008667 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | yDf10 | |||||||
| Positive_clone | C32A3 | Person_evidence | WBPerson928 | ||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 3772 | |||||||
| 3773 | |||||||||
| 4519 | |||||||||
| Pos_neg_data | 10177 | ||||||||
| Reference (33) | |||||||||
| Remark | Data extracted from Tax et al. (1997) | ||||||||
| [Iva Greenwald] sequence information published in Doyle et al., PNAS 97, 7877-7881, 2000 | |||||||||
| Sequence connection from [Doyle TG] | |||||||||
| lag-3 has been merged into this gene | |||||||||
| Method | Gene |
