WormBase Tree Display for Gene: WBGene00004769
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| WBGene00004769 | SMap | S_parent | Sequence | F35H12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sel-12 | Person_evidence | WBPerson220 | |||||
| Sequence_name | F35H12.3 | ||||||||
| Molecular_name | F35H12.3 | ||||||||
| F35H12.3.1 | |||||||||
| CE24946 | |||||||||
| Other_name | sum-1 | ||||||||
| CELE_F35H12.3 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | sel-12 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sel | ||||||||
| Allele (45) | |||||||||
| Legacy_information | [Levitan D] suppressor of multivulva phenotype.... | ||||||||
| [C.elegansII] ar131 : (pka sum-1) recessive suppressor of Muv phenotype of lin-12 hypermorph n950; impenetrant Egl in lin-12(+) background.OA3: ar133, ar171 (100% Egl, ar171/Df similar,W225op). Cloned: encodes predicted 467 aa protein, 9 TM domains; related to human presenilin genes(S182) and to SPE-4. [Levitan and Greenwald 1995; GS] | |||||||||
| Strain | WBStrain00032365 | ||||||||
| WBStrain00000196 | |||||||||
| WBStrain00004785 | |||||||||
| WBStrain00008024 | |||||||||
| WBStrain00008029 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (47) | |||||||||
| Contained_in_operon | CEOPX008 | ||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00001985 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004958 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways; sel-12 presenilin activity and/or levels are likely regulated by the SET/NAP protein sub-family member encoded by spr-2, as mutations in sel-12 are suppressed by mutations in spr-2; spr-2 regulation of sel-12 occurs in a hop-1 presenilin dependent manner. | Paper_evidence | WBPaper00002285 | |||||
| WBPaper00004474 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Mar 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable endopeptidase activity. Involved in several processes, including apical protein localization; egg-laying behavior; and regulation of signal transduction. Located in perinuclear region of cytoplasm. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; Alzheimer's disease 4; Pick's disease; dilated cardiomyopathy (multiple); and hidradenitis suppurativa. Is an ortholog of human PSEN1 (presenilin 1) and PSEN2 (presenilin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00002934 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9508,HGNC:9509) | |||||
| DOID:0110427 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9509) | ||||||
| DOID:9255 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9508) | ||||||
| DOID:0110042 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9508) | ||||||
| DOID:2280 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9508) | ||||||
| DOID:0110040 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9509) | ||||||
| DOID:0110455 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9508) | ||||||
| DOID:11870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9508) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9509) | ||||||
| Models_disease_in_annotation | WBDOannot00000336 | ||||||||
| Models_disease_asserted | WBDOannot00000651 | ||||||||
| Molecular_info | Corresponding_CDS | F35H12.3 | |||||||
| Corresponding_transcript | F35H12.3.1 | ||||||||
| Other_sequence (66) | |||||||||
| Associated_feature | WBsf647805 | ||||||||
| WBsf655164 | |||||||||
| WBsf662443 | |||||||||
| WBsf662444 | |||||||||
| WBsf662445 | |||||||||
| WBsf1003893 | |||||||||
| WBsf235293 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00097971 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00014382 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067742 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027643 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046425 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089070 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1288 | ||||||||
| Expr1609 | |||||||||
| Expr8698 | |||||||||
| Expr1010540 | |||||||||
| Expr1032363 | |||||||||
| Expr1150293 | |||||||||
| Expr2015730 | |||||||||
| Expr2033963 | |||||||||
| Drives_construct (23) | |||||||||
| Construct_product | WBCnstr00000183 | ||||||||
| WBCnstr00000184 | |||||||||
| WBCnstr00007296 | |||||||||
| WBCnstr00007297 | |||||||||
| WBCnstr00007298 | |||||||||
| WBCnstr00007299 | |||||||||
| WBCnstr00007303 | |||||||||
| WBCnstr00007307 | |||||||||
| WBCnstr00010193 | |||||||||
| WBCnstr00035399 | |||||||||
| Antibody | WBAntibody00000334 | ||||||||
| WBAntibody00000335 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (90) | |||||||||
| Interaction (247) | |||||||||
| Anatomy_function | WBbtf0184 | ||||||||
| WBbtf0185 | |||||||||
| WBbtf0186 | |||||||||
| WBbtf0187 | |||||||||
| WBbtf0188 | |||||||||
| WBbtf0595 | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000065 | |||||||||
| WBbiopr:00000066 | |||||||||
| WBbiopr:00000072 | |||||||||
| Map_info | Map | X | Position | -18.9296 | Error | 0.026774 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C08A12 | |||||||
| F35H12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 2810 | |||||||
| 4163 | |||||||||
| Reference (130) | |||||||||
| Method | Gene |
