WormBase Tree Display for Gene: WBGene00004786
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| WBGene00004786 | Evidence | Paper_evidence | WBPaper00003081 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPaper00003416 | |||||||||
| SMap | S_parent | Sequence | F44A6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sex-1 | Person_evidence | WBPerson421 | |||||
| Sequence_name | F44A6.2 | ||||||||
| Molecular_name | F44A6.2 | ||||||||
| F44A6.2.1 | |||||||||
| CE03323 | |||||||||
| Other_name | nhr-24 | ||||||||
| cnr14 | Accession_evidence | EMBL | U13074 | ||||||
| CELE_F44A6.2 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | sex-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00004786 | |||||
| WormFlux | gene | WBGene00004786 | |||||||
| NDB | locus_tag | CELE_F44A6.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004786|UniProtKB=P41830 | |||||||
| family | PTHR24082 | ||||||||
| NCBI | gene | 181231 | |||||||
| RefSeq | protein | NM_001029491.5 | |||||||
| SwissProt | UniProtAcc | P41830 | |||||||
| TREEFAM | TREEFAM_ID | TF352096 | |||||||
| UniProt_GCRP | UniProtAcc | P41830 | |||||||
| OMIM | gene | 180220 | |||||||
| 180240 | |||||||||
| 601487 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sex | ||||||||
| Allele (66) | |||||||||
| Legacy_information | sex-1 for Signal Element on X. sex-1 hermaphrodites are Dpy, Egl and Tra, males are wild type. Encodes predicted nuclear hormone receptor, gene F44A6.2,published as CNR14 by Kostrouch et al. (1995), aka nhr-24 | ||||||||
| Strain | WBStrain00028733 | ||||||||
| WBStrain00035136 | |||||||||
| WBStrain00036740 | |||||||||
| WBStrain00036791 | |||||||||
| WBStrain00036806 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (56) | |||||||||
| Paralog (217) | |||||||||
| Structured_description | Concise_description | sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males. | Paper_evidence | WBPaper00003262 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Oct 2005 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in primary sex determination and regulation of gene expression. Located in nucleus. Expressed in gonad; intestine; oocyte; and ventral uterine precursor. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); liver disease (multiple); and lung carcinoma (multiple). Is an ortholog of human NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (27) | ||||||||
| Molecular_info | Corresponding_CDS | F44A6.2 | |||||||
| Corresponding_CDS_history | F44A6.2a:wp144 | ||||||||
| F44A6.2b:wp144 | |||||||||
| Corresponding_transcript | F44A6.2.1 | ||||||||
| Other_sequence | U13074 | ||||||||
| JI175482.1 | |||||||||
| EF066631.1 | |||||||||
| CR04735 | |||||||||
| AF367207.1 | |||||||||
| JI168358.1 | |||||||||
| CRC05784_1 | |||||||||
| Associated_feature (21) | |||||||||
| Transcription_factor | WBTranscriptionFactor000302 | ||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern | Expr1581 | ||||||||
| Expr7557 | |||||||||
| Expr8032 | |||||||||
| Expr15144 | |||||||||
| Expr1016094 | |||||||||
| Expr1032373 | |||||||||
| Expr1151099 | |||||||||
| Expr1200128 | |||||||||
| Expr2015785 | |||||||||
| Expr2034018 | |||||||||
| Drives_construct | WBCnstr00012702 | ||||||||
| WBCnstr00035389 | |||||||||
| Construct_product | WBCnstr00016585 | ||||||||
| WBCnstr00016774 | |||||||||
| WBCnstr00035389 | |||||||||
| Antibody | WBAntibody00000976 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (193) | |||||||||
| Interaction (105) | |||||||||
| WBProcess | WBbiopr:00000056 | ||||||||
| Map_info | Map | X | Position | 1.8824 | Error | 0.018071 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | stDp2 | |||||||
| Positive_clone | C06F4 | ||||||||
| F44A6 | Person_evidence | WBPerson600 | |||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4909 | |||||||
| Pos_neg_data | 9151 | ||||||||
| Reference (65) | |||||||||
| Remark | nhr-24 is predicted gene F44A6.2, pka cnr-14 | ||||||||
| sex-1 designation takes precedence, nhr-24 retired [021217 ck1] | |||||||||
| Method | Gene |
