WormBase Tree Display for Gene: WBGene00004829
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| WBGene00004829 | SMap | S_parent | Sequence | M02A10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sli-1 | Person_evidence | WBPerson625 | |||||
| Sequence_name | M02A10.3 | ||||||||
| Molecular_name | M02A10.3a | ||||||||
| M02A10.3a.1 | |||||||||
| CE25058 | |||||||||
| M02A10.3b | |||||||||
| CE27393 | |||||||||
| M02A10.3c | |||||||||
| CE37131 | |||||||||
| M02A10.3b.1 | |||||||||
| M02A10.3c.1 | |||||||||
| Other_name | CELE_M02A10.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sli-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sli | ||||||||
| Allele (90) | |||||||||
| Legacy_information | [Yoon CH] positive clone restores Vul phenotype, suppresses hyperinduction. [injected into animals of the genotype let-23(sy1); sli-1(sy143) and let-23(sy1); sli-1(sy129)]. | ||||||||
| [C.elegansII] sy143 : suppressor of vulvaless phenotype of let-23 hypomorph; other let-23 defects suppressed, but not sterility; multivulva phenotype in combination with unc-101; low penetrance head morphology defect in let-23(+) background. sy143/Df similar. OA>10: sy263 (weaker), sy129 etc. Cloned: encodes homolog of mammalian oncogene c-cbl (55% identity over 390 aa, containing RING finger motif. sy129 missense. [Jongeward et al. 1995; Yoon et al. 1995; PS] | |||||||||
| Strain | WBStrain00027422 | ||||||||
| WBStrain00030821 | |||||||||
| WBStrain00030825 | |||||||||
| WBStrain00030829 | |||||||||
| WBStrain00030830 | |||||||||
| WBStrain00030836 | |||||||||
| WBStrain00030870 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | sli-1 encodes the C. elegans ortholog of the Cbl family of ubiquitin ligases; sli-1 was originally identified as a suppressor of a hypomorphic mutation in LET-23/EGFR and thus, is predicted to function as a negative regulator of LET-23-mediated signaling; genetic analyses place sli-1 upstream of let-60/Ras; a chimeric protein substituting human SH2 and RING finger domains for those of SLI-1 is partially functional for regulating vulval differentiation in vivo; sli-1(RNAi) in the background of a let-756/FGF mutant results in slow growing animals. | Paper_evidence | WBPaper00002148 | |||||
| WBPaper00002227 | |||||||||
| WBPaper00004417 | |||||||||
| WBPaper00027336 | |||||||||
| WBPaper00031036 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 31 Oct 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of vulval development. Predicted to be located in membrane raft and plasma membrane. Expressed in several structures, including anal depressor muscle; body wall musculature; distal tip cell; head; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung squamous cell carcinoma. Is an ortholog of human CBL (Cbl proto-oncogene); CBLB (Cbl proto-oncogene B); and CBLC (Cbl proto-oncogene C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (12) | ||||||||
| Molecular_info | Corresponding_CDS | M02A10.3a | |||||||
| M02A10.3b | |||||||||
| M02A10.3c | |||||||||
| Corresponding_transcript | M02A10.3a.1 | ||||||||
| M02A10.3b.1 | |||||||||
| M02A10.3c.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr10710 | ||||||||
| Expr1010899 | |||||||||
| Expr1032403 | |||||||||
| Expr1154494 | |||||||||
| Expr2015883 | |||||||||
| Expr2034116 | |||||||||
| Drives_construct | WBCnstr00017482 | ||||||||
| WBCnstr00035358 | |||||||||
| Construct_product | WBCnstr00017482 | ||||||||
| WBCnstr00035358 | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (99) | |||||||||
| WBProcess | WBbiopr:00000071 | ||||||||
| Map_info | Map | X | Position | -19.5052 | Error | 0.003049 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | M02A10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| T18D5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Negative_clone | F02G3 | |||||||
| F25E2 | |||||||||
| F25H6 | |||||||||
| Mapping_data | Multi_point | 2319 | |||||||
| 2320 | |||||||||
| 4971 | |||||||||
| Pos_neg_data | 5879 | ||||||||
| 6860 | |||||||||
| 6861 | |||||||||
| 6862 | |||||||||
| Reference (71) | |||||||||
| Method | Gene |
