WormBase Tree Display for Gene: WBGene00004858

WBGene00004858 SMap: S_parent: Sequence: R12B2
  Identity: Version: 1
    Name: CGC_name: sma-4 Person_evidence: WBPerson261
      Sequence_name: R12B2.1
      Molecular_name: R12B2.1a
        R12B2.1a.1
        CE25077
        R12B2.1b
        CE39618
        R12B2.1a.2
        R12B2.1b.1
      Other_name: CELE_R12B2.1 Accession_evidence: NDB BX284603
      Public_name: sma-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sma
    Reference_allele: WBVar00143436
    Allele (61)
    Legacy_information: e729 : short non-dumpy; males have crumpled spicules. ES3 (adult) ME0. NA2 (e805).
      [C.elegansII] e729 : short non-dumpy; males have crumpled spicules, abnormal rays. ES3 (adult) ME0. OA1 (e805). [Brenner 1974; LT; PB]
    Strain (7)
    RNASeq_FPKM (74)
    GO_annotation (39)
    Ortholog (38)
    Paralog: WBGene00000904 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000910 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004856 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004857 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006445 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000899 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sma-4 encodes a Smad protein and a homolog of human DPC4, which when mutated leads to pancreatic carcinoma (OMIM:260350); SMA-4 is similar to members of the vertebrate protein family of Dwarfins; during development, sma-4 functions as part of a DBL-1/SMA-6 TGF-beta-related signaling pathway that controls body size and male tail sensory ray and spicule formation; sma-4, through this pathway, also regulates reproductive aging; studies have shown that a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; SMA-4 can physically interact with the RNT-1/RUNX transcription factor, which interacts and functions with the TGF-beta signaling pathway, in regulating body size and male tail development. Paper_evidence: WBPaper00002374
            WBPaper00004103
            WBPaper00024401
            WBPaper00030727
            WBPaper00035556
            WBPaper00037682
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 18 Jan 2011 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of growth. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Expressed in head neurons and pseudocoelom. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and female reproductive organ cancer (multiple). Is an ortholog of human SMAD4 (SMAD family member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (23)
  Molecular_info: Corresponding_CDS: R12B2.1a
      R12B2.1b
    Corresponding_CDS_history: R12B2.1:wp153
    Corresponding_transcript: R12B2.1a.1
      R12B2.1a.2
      R12B2.1b.1
    Other_sequence (19)
    Associated_feature: WBsf645214
      WBsf978482
      WBsf992539
      WBsf1014960
      WBsf225002
      WBsf225003
    Transcription_factor: WBTranscriptionFactor001046
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr7640
      Expr1013575
      Expr1032410
      Expr1155487
      Expr2015894
      Expr2034127
    Drives_construct: WBCnstr00012785
      WBCnstr00035352
    Construct_product: WBCnstr00035352
    Regulate_expr_cluster: WBPaper00037682:sma-2_sma-4_downregulated
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053184:sma-4(rax3)_upregulated
    Microarray_results (29)
    Expression_cluster (146)
    Interaction (205)
    WBProcess: WBbiopr:00000025
      WBbiopr:00000039
  Map_info: Map: III Position: -1.43987 Error: 0.00065
    Well_ordered
    Positive: Positive_clone: R12B2 Inferred_automatically: From sequence, transcript, pseudogene data
        W03A3
    Mapping_data: 2_point: 63
        6133
        7029
      Multi_point (11)
      Pos_neg_data: 2712
        2713
        7310
        8705
        8734
        8764
        8766
        8833
  Reference: WBPaper00000031
    WBPaper00000608
    WBPaper00001057
    WBPaper00001328
    WBPaper00002374
    WBPaper00002828
    WBPaper00002897
    WBPaper00002913
    WBPaper00003092
    WBPaper00003400
    WBPaper00003401
    WBPaper00003454
    WBPaper00003579
    WBPaper00003626
    WBPaper00003780
    WBPaper00003844
    WBPaper00003854
    WBPaper00003935
    WBPaper00004160
    WBPaper00004199
    WBPaper00004925
    WBPaper00005046
    WBPaper00005165
    WBPaper00005197
    WBPaper00005325
    WBPaper00005463
    WBPaper00005567
    WBPaper00005654
    WBPaper00005732
    WBPaper00005854
    WBPaper00005858
    WBPaper00006103
    WBPaper00006272
    WBPaper00006302
    WBPaper00006346
    WBPaper00006351
    WBPaper00006437
    WBPaper00006506
    WBPaper00010116
    WBPaper00010119
    WBPaper00010219
    WBPaper00010347
    WBPaper00010521
    WBPaper00010553
    WBPaper00010554
    WBPaper00010898
    WBPaper00010925
    WBPaper00010966
    WBPaper00010981
    WBPaper00011036
    WBPaper00011065
    WBPaper00011094
    WBPaper00011130
    WBPaper00011197
    WBPaper00011841
    WBPaper00013466
    WBPaper00013909
    WBPaper00014082
    WBPaper00014836
    WBPaper00014913
    WBPaper00014948
    WBPaper00015020
    WBPaper00015108
    WBPaper00015112
    WBPaper00015228
    WBPaper00015229
    WBPaper00015231
    WBPaper00015232
    WBPaper00015233
    WBPaper00015293
    WBPaper00015294
    WBPaper00015295
    WBPaper00015356
    WBPaper00015420
    WBPaper00015421
    WBPaper00015466
    WBPaper00015467
    WBPaper00017297
    WBPaper00017512
    WBPaper00018517
    WBPaper00018518
    WBPaper00018520
    WBPaper00019048
    WBPaper00019683
    WBPaper00021649
    WBPaper00021693
    WBPaper00021761
    WBPaper00022150
    WBPaper00022262
    WBPaper00022279
    WBPaper00022679
    WBPaper00022694
    WBPaper00022737
    WBPaper00022782
    WBPaper00023410
    WBPaper00023411
    WBPaper00023637
    WBPaper00023777
    WBPaper00024401
    WBPaper00024429
    WBPaper00025180
    WBPaper00026103
    WBPaper00026515
    WBPaper00026632
    WBPaper00026644
    WBPaper00027295
    WBPaper00027307
    WBPaper00027702
    WBPaper00030645
    WBPaper00030727
    WBPaper00030983
    WBPaper00031016
    WBPaper00031355
    WBPaper00031625
    WBPaper00031786
    WBPaper00031872
    WBPaper00032029
    WBPaper00032891
    WBPaper00036735
    WBPaper00037541
    WBPaper00038491
    WBPaper00043875
    WBPaper00048327
    WBPaper00051537
    WBPaper00052255
    WBPaper00052358
    WBPaper00053184
    WBPaper00055090
    WBPaper00055618
    WBPaper00058342
    WBPaper00060096
    WBPaper00060493
    WBPaper00061709
    WBPaper00061717
    WBPaper00061718
    WBPaper00061938
    WBPaper00063272
    WBPaper00064756
  Picture: WBPicture0000013077
  Method: Gene