WormBase Tree Display for Gene: WBGene00004877
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| WBGene00004877 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K11G12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | smf-2 | Person_evidence | WBPerson168 | |||||
| Sequence_name | K11G12.3 | ||||||||
| Molecular_name | K11G12.3 | ||||||||
| K11G12.3.1 | |||||||||
| CE47234 | |||||||||
| Other_name | CELE_K11G12.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | smf-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | smf | ||||||||
| Allele (38) | |||||||||
| Strain | WBStrain00035556 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00004876 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004878 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | smf-2 encodes one of three C. elegans divalent-metal ion transporters (DMTs) orthologous to the mammalian DMT1 transporters and Saccharomyces cerevisiae Smf proteins; in C. elegans, SMF-2 appears to function as both a manganese and iron transporter that regulates metal content; mutations in smf-2 display a decreased tolerance to manganeseexposure; SMF-2 is expressed mainly in the marginal pharyngeal epithelium from late embryogenesis through adulthood; SMF-2 localizes primarily to cytoplasmic compartments, with some apical plasma membrane localization seen in the mc cells; smf-2 is overexpressed in smf-1 and smf-3 mutants, and SMF-2 appears to be required for smf-1 and smf-3 expression changes in response to manganese; when expressed in Saccharomyces cerevisiae, smf-2 can rescue the EGTA hypersensitivity of Smf1+2 mutants. | Paper_evidence | WBPaper00035485 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Aug 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; and manganese ion transmembrane transporter activity. Involved in intracellular iron ion homeostasis; manganese ion homeostasis; and response to manganese ion. Located in apical plasma membrane. Expressed in dopaminergic neurons; gonadal sheath cell; marginal cell; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); leishmaniasis (multiple); and neurodegenerative disease (multiple). Is an ortholog of human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (25) | ||||||||
| Molecular_info | Corresponding_CDS | K11G12.3 | |||||||
| Corresponding_CDS_history | K11G12.3:wp230 | ||||||||
| Corresponding_transcript | K11G12.3.1 | ||||||||
| Other_sequence (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00082082 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00082081 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061411 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082084 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082086 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050612 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050611 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034290 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017019 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8812 | ||||||||
| Expr8860 | |||||||||
| Expr1016457 | |||||||||
| Expr1154319 | |||||||||
| Expr2015905 | |||||||||
| Expr2034138 | |||||||||
| Drives_construct | WBCnstr00013569 | ||||||||
| WBCnstr00019899 | |||||||||
| WBCnstr00035345 | |||||||||
| Construct_product | WBCnstr00035345 | ||||||||
| Antibody | WBAntibody00001997 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (41) | |||||||||
| Interaction (55) | |||||||||
| Map_info | Map | X | Position | -2.5477 | Error | 0.004848 | |||
| Positive | Positive_clone | K11G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4665 | |||||||
| 4666 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
