WormBase Tree Display for Gene: WBGene00004951
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WBGene00004951 | SMap | S_parent | Sequence | K10B3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | spc | ||||||
Allele (142) | |||||||
Possibly_affected_by | WBVar02152908 | ||||||
Legacy_information | [Norman KR] imo for incomplete morphogenesis. imo-1 (ra409) homozygotes are L1 lethals due to a defect in embryonic elongation. | ||||||
re-named to spc-1 for spectrin [sdm/jah] | |||||||
Complementation_data | [Norman KR] complements dpy-3 (e27), dpy-7 (sc27), lon-2 (e678), unc-2 (e55), unc- 20 (e112), unc-78 (e1217) | ||||||
Strain | WBStrain00005882 | ||||||
WBStrain00034760 | |||||||
WBStrain00047279 | |||||||
WBStrain00047277 | |||||||
WBStrain00047274 | |||||||
WBStrain00047278 | |||||||
RNASeq_FPKM (73) | |||||||
GO_annotation (17) | |||||||
Ortholog (37) | |||||||
Paralog (13) | |||||||
Structured_description | Concise_description | spc-1 encodes the C. elegans alpha spectrin ortholog; during development, spc-1 activity is required for body morphogenesis, formation of body wall muscles, locomotion, and larval development. | Paper_evidence | WBPaper00004127 | |||
WBPaper00005321 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 31 Jan 2007 00:00:00 | ||||||
Automated_description | Predicted to enable actin filament binding activity. Involved in several processes, including embryonic body morphogenesis; nematode larval development; and regulation of growth. Predicted to be located in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Expressed in several structures, including body wall musculature; hermaphrodite gonad; intestine; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 5 and hereditary spherocytosis type 3. Is an ortholog of human SPTAN1 (spectrin alpha, non-erythrocytic 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | EFO:MONDO:0015362 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11273) | ||
DOID:0080438 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11273) | ||||
DOID:0110918 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11272) | ||||
DOID:12971 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11272) | ||||
Molecular_info | Corresponding_CDS | K10B3.10a | |||||
K10B3.10b | |||||||
Corresponding_transcript | K10B3.10a.1 | ||||||
K10B3.10b.1 | |||||||
Other_sequence (138) | |||||||
Associated_feature (24) | |||||||
Experimental_info | RNAi_result | WBRNAi00060090 | Inferred_automatically | RNAi_primary | |||
WBRNAi00060091 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00060092 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025934 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00050477 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00000485 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00080495 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00008979 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022774 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00060093 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (13) | |||||||
Drives_construct | WBCnstr00035308 | ||||||
WBCnstr00041562 | |||||||
Construct_product | WBCnstr00035308 | ||||||
WBCnstr00041562 | |||||||
Regulate_expr_cluster | WBPaper00057041:spc-1(cas971)_downregulated | ||||||
WBPaper00057041:spc-1(cas971)_upregulated | |||||||
Antibody | WBAntibody00000528 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (216) | |||||||
Interaction (480) | |||||||
WBProcess | WBbiopr:00000006 | ||||||
Map_info | Map | X | Position | -12.1435 | Error | 0.053657 | |
Well_ordered | |||||||
Positive | Inside_rearr | mnDp33 | |||||
Positive_clone | K10B3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
M01F12 | |||||||
Mapping_data | Multi_point | 3805 | |||||
3806 | |||||||
5603 | |||||||
Pos_neg_data | 10240 | ||||||
Reference (35) | |||||||
Method | Gene |