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WormBase Tree Display for Gene: WBGene00005023

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Name Class

WBGene00005023EvidencePaper_evidenceWBPaper00005867
SMapS_parentSequenceT24D1
IdentityVersion2
NameCGC_namesqv-5Person_evidenceWBPerson268
Sequence_nameT24D1.1
Molecular_nameT24D1.1a
T24D1.1a.1
CE50401
T24D1.1b
CE39182
T24D1.1c
CE50402
T24D1.1b.1
T24D1.1c.1
Other_nameChSy-SAccession_evidenceEMBLAB088398
CELE_T24D1.1Accession_evidenceNDBBX284601
Public_namesqv-5
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:37WBPerson1971EventImportedInitial conversion from geneace
202 Mar 2018 11:09:16WBPerson4025EventSplit_intoWBGene00303082
Split_intoWBGene00303082
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsqv
Allele (53)
Legacy_information[Herman T] sqv for squashed vulva. morphology of L4 vulva abnormal (invagination considerably reduced). hermaphrodites self-sterile.
[C.elegansII] n3039 : morphology of L4 vulva abnormal (invagination considerably reduced); hermaphrodites self-sterile. [MT]
StrainWBStrain00027364
WBStrain00027385
WBStrain00028700
WBStrain00028702
WBStrain00007564
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (44)
ParalogWBGene00003253Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionsqv-5 encodes a chondroitin synthase that both initiates and elongates chondroitin chains (unlike human chondroitin synthase, which only elongates them); SQV-5 is required for cytokinesis (e.g., at the one-cell embryo stage), gonad migration, and vulval morphogenesis (by expanding the extracellular space of the vulva in L4 larvae); the common requirement for SQV-5 in both processes may be to promote filling an extracellular space with fluid (either in the eggshell, or underneath the L4 cuticle); SQV-5 colocalizes with SQV-1 at punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes; SQV-5 is most similar to human chondroitin synthase (KIAA0990) and Drosophila CG9220.Paper_evidenceWBPaper00003405
WBPaper00003736
WBPaper00003906
WBPaper00005540
WBPaper00005867
WBPaper00005868
WBPaper00012887
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables enzyme binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and vulval development. Located in cytoplasm. Expressed in oocyte; uterus; and vulva. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Is an ortholog of human CHSY1 (chondroitin sulfate synthase 1) and CHSY3 (chondroitin sulfate synthase 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050814Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17198)
Molecular_infoCorresponding_CDST24D1.1a
T24D1.1b
T24D1.1c
Corresponding_CDS_historyT24D1.1a:wp149
T24D1.1a:wp246
T24D1.1b:wp149
T24D1.1d:wp264
Corresponding_transcriptT24D1.1a.1
T24D1.1b.1
T24D1.1c.1
Other_sequence (32)
Associated_feature (14)
Experimental_infoRNAi_result (14)
Expr_patternExpr2566
Expr3104
Expr1023591
Expr1032506
Expr1157585
Expr2016123
Expr2034358
Drives_constructWBCnstr00018534
WBCnstr00035261
Construct_productWBCnstr00018534
WBCnstr00035261
AntibodyWBAntibody00000621
WBAntibody00001858
Microarray_results (29)
Expression_cluster (160)
InteractionWBInteraction000052639
WBInteraction000052640
WBInteraction000052641
WBInteraction000052645
WBInteraction000052646
WBInteraction000052647
WBInteraction000182634
WBInteraction000213033
WBInteraction000217208
WBInteraction000219699
WBInteraction000220913
WBInteraction000227481
WBInteraction000230301
WBInteraction000241218
WBInteraction000249451
WBInteraction000265335
WBInteraction000269250
WBInteraction000271550
WBInteraction000288978
WBInteraction000297435
WBInteraction000302287
WBInteraction000317276
WBInteraction000322020
WBInteraction000328298
WBInteraction000329830
WBInteraction000330444
WBInteraction000330698
WBInteraction000333410
WBInteraction000348232
WBInteraction000349526
WBInteraction000349563
WBInteraction000352084
WBInteraction000369404
WBInteraction000369710
WBInteraction000371358
WBInteraction000371715
WBInteraction000372377
WBInteraction000378600
WBInteraction000379256
WBInteraction000380026
WBInteraction000386070
WBInteraction000390694
WBInteraction000392178
WBInteraction000403087
WBInteraction000403173
WBInteraction000408330
WBInteraction000409326
WBInteraction000412137
WBInteraction000414413
WBInteraction000420993
WBInteraction000423599
WBInteraction000428277
WBInteraction000437232
WBInteraction000440759
WBInteraction000442807
WBInteraction000443414
WBInteraction000445191
WBInteraction000446964
WBInteraction000454712
WBInteraction000456393
WBInteraction000457903
WBInteraction000458981
WBInteraction000462369
WBInteraction000462474
WBInteraction000520689
WBInteraction000522573
Map_infoMapIPosition4.09354Error0.007416
PositivePositive_cloneT24D1Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point3143
3144
5407
5544
Reference (32)
MethodGene