WormBase Tree Display for Gene: WBGene00005077
expand all nodes | collapse all nodes | view schema
| WBGene00005077 | SMap | S_parent | Sequence | Y92H12A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | src-1 | Person_evidence | WBPerson419 | |||||
| Sequence_name | Y92H12A.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_Y92H12A.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | src-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | src | ||||||||
| Allele (443) | |||||||||
| Possibly_affected_by | WBVar02153238 | ||||||||
| WBVar02158602 | |||||||||
| Legacy_information | [C.elegansII] Tc5 insertion obtained. Similarity to src oncogene. Not localized on physical map. | ||||||||
| Strain | WBStrain00032711 | ||||||||
| WBStrain00040423 | |||||||||
| WBStrain00008460 | |||||||||
| WBStrain00055192 | |||||||||
| Component_of_genotype | WBGenotype00000149 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (53) | |||||||||
| Ortholog (65) | |||||||||
| Paralog (45) | |||||||||
| Structured_description | Concise_description | src-1 encodes a non-receptor tyrosine kinase; during embryonic development, src-1 functions together with a Wnt signaling pathway to specify endodermal cell fate and division orientation of the EMS blastomere; src-1 also functions in an unc-5-mediated pathway to regulate cell and axon migration; SRC-1 physically interacts with UNC-5; src-1 also functions in the engulfing cell during cell corpse engulfment together with ina-1/integrin and ced-2/CrkII ; SRC-1 physically interacts with both CED-2 and INA-1, therefore acting as a bridging molecule that may link INA-1 to the CED-2-CED-5-CED-12 complex for CED-10/Rac activation; in addition to being widely expressed, SRC-1 colocalizes with INA-1 to the pseudopods of phagocytes that are extended around apoptotic cells. | Paper_evidence | WBPaper00005375 | |||||
| WBPaper00005681 | |||||||||
| WBPaper00026685 | |||||||||
| WBPaper00026923 | |||||||||
| WBPaper00036041 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 07 Sep 2011 00:00:00 | ||||||||
| Automated_description | Enables netrin receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including anatomical structure morphogenesis; axis specification; and establishment of mitotic spindle orientation. Located in contractile fiber and phagocytic cup. Expressed in several structures, including anchor cell; anus; distal tip cell; head neurons; and vulval cell. Used to study Goldenhar syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; diabetes mellitus (multiple); gastrointestinal system cancer (multiple); and lung non-small cell carcinoma (multiple). Is an ortholog of human FYN (FYN proto-oncogene, Src family tyrosine kinase); SRC (SRC proto-oncogene, non-receptor tyrosine kinase); and YES1 (YES proto-oncogene 1, Src family tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:2907 | Homo sapiens | Paper_evidence | WBPaper00065557 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Jul 2023 00:00:00 | ||||||||
| Potential_model (19) | |||||||||
| Models_disease_in_annotation | WBDOannot00001387 | ||||||||
| Models_disease_asserted | WBDOannot00001388 | ||||||||
| Molecular_info | Corresponding_CDS | Y92H12A.1a | |||||||
| Y92H12A.1b | |||||||||
| Y92H12A.1c | |||||||||
| Y92H12A.1d | |||||||||
| Corresponding_CDS_history | Y92H12A.1:wp155 | ||||||||
| Corresponding_transcript | Y92H12A.1a.1 | ||||||||
| Y92H12A.1b.1 | |||||||||
| Y92H12A.1c.1 | |||||||||
| Y92H12A.1d.1 | |||||||||
| Other_sequence (77) | |||||||||
| Associated_feature | WBsf655938 | ||||||||
| WBsf655939 | |||||||||
| WBsf655940 | |||||||||
| WBsf982717 | |||||||||
| WBsf982718 | |||||||||
| WBsf982719 | |||||||||
| WBsf1009228 | |||||||||
| WBsf217221 | |||||||||
| WBsf217222 | |||||||||
| WBsf217223 | |||||||||
| Experimental_info | RNAi_result (88) | ||||||||
| Expr_pattern | Expr2313 | ||||||||
| Expr3921 | |||||||||
| Expr11830 | |||||||||
| Expr15166 | |||||||||
| Expr1020111 | |||||||||
| Expr1032511 | |||||||||
| Expr1162046 | |||||||||
| Expr2016218 | |||||||||
| Expr2034454 | |||||||||
| Drives_construct | WBCnstr00010762 | ||||||||
| WBCnstr00011750 | |||||||||
| Antibody | WBAntibody00001610 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (72) | |||||||||
| Interaction (344) | |||||||||
| Anatomy_function | WBbtf0760 | ||||||||
| WBbtf0761 | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | I | Position | -14.583 | Error | 0.121255 | |||
| Positive | Positive_clone | MC#L210 | |||||||
| Y92H12A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 5373 | |||||||
| Reference (70) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Remark | JAH assumes src-1 equals this sequence. | ||||||||
| Method | Gene |
