WormBase Tree Display for Gene: WBGene00005155
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| WBGene00005155 | Identity | Version | 1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | CGC_name | srf-5 | Person_evidence | WBPerson494 | |||||
| Public_name | srf-5 | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Gene_class | srf | |||||||
| Allele | WBVar01202449 | Inferred_automatically | From strain object: CB7191 | ||||||
| WBVar00054547 | Inferred_automatically | From strain object: CL261 | |||||||
| WBVar00142873 | |||||||||
| WBVar00142866 | |||||||||
| WBVar00142864 | |||||||||
| WBVar00144928 | |||||||||
| WBVar00142854 | |||||||||
| WBVar00054542 | |||||||||
| Legacy_information | [C.elegansII] ct115 : ectopic surface binding of lectins SBA, WGA. OA5: ct114, dv18, dv32, dv40 etc. [Link et al. 1992; CL] | ||||||||
| Strain | WBStrain00004746 | ||||||||
| WBStrain00005058 | |||||||||
| Structured_description | Concise_description | srf-5 was identified as a mutation that alters the surface antigenicity of the cuticle in C. elegans; srf-5 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-5 mutants are resistant to infection by the nematode-specific pathogen, Microbacterium nematophilum and do not show the tail-swelling response to infection; srf-5 mutants also show an altered response in the form of increased susceptibility to nematophagous fungi. | Paper_evidence | WBPaper00001576 | |||||
| WBPaper00001002 | |||||||||
| WBPaper00001706 | |||||||||
| WBPaper00001280 | |||||||||
| WBPaper00004539 | |||||||||
| WBPaper00003623 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Oct 2011 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00029153 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Nov 2023 00:00:00 | ||||||||
| Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||||
| WBPaper00026735 | |||||||||
| WBPaper00029153 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000017 | ||||||||
| Experimental_info | Expr_pattern | Expr16441 | |||||||
| Drives_construct | WBCnstr00043023 | ||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | X | Position | 11.603 | Error | 1.10119 | |||
| Mapping_data | 2_point | 5007 | |||||||
| Multi_point | 1770 | ||||||||
| Reference (27) | |||||||||
| Method | Gene |
