WormBase Tree Display for Gene: WBGene00006412
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| WBGene00006412 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | nlg-1 | Person_evidence | WBPerson508 | |||||
| WBPerson36909 | |||||||||
| WBPerson7188 | |||||||||
| Sequence_name | C40C9.5 | ||||||||
| Molecular_name (27) | |||||||||
| Other_name | tag-27 | CGC_data_submission | |||||||
| cest-14 | |||||||||
| CELE_C40C9.5 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | nlg-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 15 Nov 2004 13:45:12 | WBPerson2970 | Name_change | CGC_name | nlg-1 | ||||
| 3 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | nlg-1 | ||||
| Other_name | cest-14 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nlg | ||||||||
| Allele (111) | |||||||||
| Strain | WBStrain00002633 | ||||||||
| WBStrain00002517 | |||||||||
| WBStrain00035599 | |||||||||
| WBStrain00007561 | |||||||||
| WBStrain00005130 | |||||||||
| WBStrain00005129 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (52) | |||||||||
| Paralog (38) | |||||||||
| Structured_description | Concise_description | nlg-1 encodes the sole C. elegans neuroligin homolog; nlg-1 activity is required for a subset of sensory behaviors and sensory processing, and for normal sensitivity to oxidative stress and mercury compounds; NLG-1 is expressed in a variety of neurons, including sensory, motor, and interneurons, and localizes to synaptic regions. | Paper_evidence | WBPaper00031496 | |||||
| WBPaper00035615 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Jan 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable neurexin family protein binding activity and signaling receptor activity. Involved in gamma-aminobutyric acid receptor clustering and negative regulation of neurotransmitter secretion. Located in axon; dendrite; and synapse. Expressed in several structures, including body wall musculature; diagonal muscle; neurons; tail; and ventral nerve cord. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human NLGN4Y (neuroligin 4 Y-linked). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060041 | Homo sapiens | Paper_evidence | WBPaper00041217 | ||||
| WBPaper00048837 | |||||||||
| WBPaper00035582 | |||||||||
| Accession_evidence | OMIM | 300425 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Apr 2013 00:00:00 | ||||||||
| Potential_model | DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14287,HGNC:14289) | |||||
| Disease_relevance | Mutations in mammalian neuroligins (orthlogous to elegans nlg-1) are involved in mental retardation and autism spectrum disorders (ASDs); neuroligins are post-synaptic cell adhesion molecules and function along with the pre-synaptic neurexins in synaptic maturation, stability and maintenance; nlg-1 mutants and knock-out worms exhibit phenotypes consistent with ASDs; nlg-1 mutants have sensory defects manifested as impaired chemotaxis, thermotaxis and osmotic avoidance, and are hyper-sensitive to toxic agents that cause oxidative stress, like paraquet, copper and mercury; rat Nlgn1 and human NLGN1 isoforms were able to rescue the wild-type phenotype in the worm. | Homo sapiens | Paper_evidence | WBPaper00040040 | |||||
| WBPaper00040403 | |||||||||
| WBPaper00041217 | |||||||||
| Accession_evidence | OMIM | 300494 | |||||||
| 300425 | |||||||||
| 300336 | |||||||||
| 600568 | |||||||||
| 300427 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Apr 2012 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000056 | ||||||||
| WBDOannot00000475 | |||||||||
| WBDOannot00000477 | |||||||||
| WBDOannot00000478 | |||||||||
| WBDOannot00000489 | |||||||||
| WBDOannot00000496 | |||||||||
| WBDOannot00000497 | |||||||||
| Molecular_info | Corresponding_CDS | C40C9.5a | |||||||
| C40C9.5b | |||||||||
| C40C9.5c | |||||||||
| C40C9.5d | |||||||||
| C40C9.5e | |||||||||
| C40C9.5f | |||||||||
| C40C9.5g | |||||||||
| C40C9.5h | |||||||||
| C40C9.5i | |||||||||
| Corresponding_CDS_history | C40C9.5:wp91 | ||||||||
| C40C9.5c:wp271 | |||||||||
| Corresponding_transcript | C40C9.5a.1 | ||||||||
| C40C9.5b.1 | |||||||||
| C40C9.5c.1 | |||||||||
| C40C9.5d.1 | |||||||||
| C40C9.5e.1 | |||||||||
| C40C9.5f.1 | |||||||||
| C40C9.5g.1 | |||||||||
| C40C9.5h.1 | |||||||||
| C40C9.5i.1 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00042252 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00080990 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00080989 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00111983 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011813 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029704 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (29) | |||||||||
| Regulate_expr_cluster | WBPaper00053023:nlg-1(ok259)_downregulated | ||||||||
| WBPaper00053023:nlg-1(ok259)_upregulated | |||||||||
| WBPaper00053023:nrx-1(tm1961);nlg-1(ok259)_downregulated | |||||||||
| WBPaper00053023:nrx-1(tm1961);nlg-1(ok259)_upregulated | |||||||||
| Antibody | WBAntibody00002883 | ||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (169) | |||||||||
| Interaction (28) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | X | Position | 13.9949 | Error | 0.030126 | |||
| Positive | Positive_clone | C40C9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5276 | |||||||
| Pseudo_map_position | |||||||||
| Reference (71) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
