WormBase Tree Display for Gene: WBGene00006433
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| WBGene00006433 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F42A8 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | sdhb-1 | Person_evidence | WBPerson205 | |||||
| Sequence_name | F42A8.2 | ||||||||
| Molecular_name | F42A8.2 | ||||||||
| F42A8.2.1 | |||||||||
| CE01579 | |||||||||
| Other_name | tag-55 | Person_evidence | WBPerson201 | ||||||
| CELE_F42A8.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | sdhb-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Jul 2006 13:35:13 | WBPerson2970 | Name_change | CGC_name | sdhb-1 | ||||
| Other_name | tag-55 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sdhb | ||||||||
| Allele (36) | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00009626 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | sdhb-1 encodes the C. elegans ortholog of human succinate dehydrogenase subunit B (SDHB; OMIM:185470, mutations lead to extraadrenal pheochromocytoma) which contains several iron-sulfur (Fe-S) clusters and functions to transfer electrons from the A (SDHA) subunit to the membrane-associated C (SDHC) subunit; RNAi screens indicate that sdhb-1 activity is essential for embryonic and larval development, as well as for normal brood sizes, body morphology, osmoregulation, and growth rate; in addition, transgenic animals expressing SDHB-1 variants at the conserved Pro211 residue exhibit various phenotypes, including hypersensitivity to oxidative stress, reduced life span, impaired respiration and excess superoxide production; sdhb-1 is widely expressed in larvae and adults and SDHB-1 localizes to mitochondria. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00005674 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00006525 | |||||||||
| WBPaper00024497 | |||||||||
| WBPaper00024944 | |||||||||
| WBPaper00032923 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 05 May 2009 00:00:00 | ||||||||
| Automated_description | Contributes to succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in aerobic respiration and respiratory electron transport chain. Located in mitochondrion. Expressed in head and tail. Used to study paraganglioma. Human ortholog(s) of this gene implicated in several diseases, including Carney-Stratakis syndrome; gastrointestinal stromal tumor; and mitochondrial complex II deficiency. Is an ortholog of human SDHB (succinate dehydrogenase complex iron sulfur subunit B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050773 | Homo sapiens | Paper_evidence | WBPaper00060158 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Jul 2022 00:00:00 | ||||||||
| Potential_model | DOID:0060537 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10681) | |||||
| DOID:0080533 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10681) | ||||||
| DOID:0050771 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10681) | ||||||
| DOID:0050773 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10681) | ||||||
| DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10681) | ||||||
| Models_disease_asserted | WBDOannot00001290 | ||||||||
| Molecular_info | Corresponding_CDS | F42A8.2 | |||||||
| Corresponding_transcript | F42A8.2.1 | ||||||||
| Other_sequence (195) | |||||||||
| Associated_feature | WBsf650423 | ||||||||
| WBsf989031 | |||||||||
| WBsf1012845 | |||||||||
| WBsf223637 | |||||||||
| WBsf223638 | |||||||||
| WBsf223639 | |||||||||
| Experimental_info | RNAi_result (46) | ||||||||
| Expr_pattern | Chronogram773 | ||||||||
| Expr6037 | |||||||||
| Expr1016349 | |||||||||
| Expr1032613 | |||||||||
| Expr1150935 | |||||||||
| Expr2015664 | |||||||||
| Expr2033897 | |||||||||
| Drives_construct | WBCnstr00003460 | ||||||||
| WBCnstr00034359 | |||||||||
| Construct_product | WBCnstr00034359 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction (129) | |||||||||
| Map_info | Map | II | Position | 1.29106 | Error | 0.002149 | |||
| Positive | Positive_clone | F42A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
